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J-GLOBAL ID：200901033020442917 Update date: Mar. 25, 2025

Nakano Toshiaki

ナカノトシアキ | Nakano Toshiaki

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Affiliation and department：
Job title：上席研究員
Homepage URL (1)： https://www.qst.go.jp/site/kansai-dqap/crrp.html

Research field (3)： Tumor biology , Genomics , Molecular biology

Research keywords (17)：癌化 , 老化 , 遺伝性疾患 , 抗癌剤 (azadC) , ミトコンドリア , 重粒子線治療 , 放射線治療 , 放射線生物学 , 全反射照明蛍光顕微鏡 (TIRF) , 原子間力顕微鏡 (AFM) , 塩基損傷 (Base damage) , 1分子生物学 , DNA損傷の定量 , DNA-protein crosslink lesion (DPC) , Interstrand crosslink lesion (ICL) , クラスターダメージ , DNA repair

Research theme for competitive and other funds (16)：

2024 - 2028 Study of DNA damage and cellular response induced by laser filamentation
2024 - 2028 修復困難な一本鎖切断の新規耐性機構及びゲノム変異生成に関する研究
2021 - 2024 一分子観察によるDNA損傷修復ダイナミクスの解明
2021 - 2023 細胞及び腫瘍に生じるクラスター損傷の可視化と修復機構の解明
2016 - 2017 放射線が誘発する高密度DNA損傷の解析

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Papers (29)：

Toshiaki Nakano, Ken Akamatsu, Masaoki Kohzaki, Masataka Tsuda, Ryoichi Hirayama, Akira Sassa, Manabu Yasui, Mahmoud I. Shoulkamy, Takeshi Hiromoto, Taro Tamada, et al. Deciphering repair pathway of clusterd DNA damage in human TK6 cells: insights from atomic force microscopy direct visualization. Nucleic Acids Research. 2024. 53. gkae1077
Yusuke Sato, Yoshihide Takaku, Toshiaki Nakano, Ken Akamatsu, Dai Inamura, Seiichi Nishizawa. Synthetic DNA binders for fluorescence sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity. Chemical communication. 2023. 59. 6088-6091
Toshiaki Nakano, Takahito Moriwaki, Masataka Tsuda, Misa Miyakawa, Yuto Hanaichi, Hiroyuki Sasanuma, Koji Hirota, Masanobu Kawanishi, Hiroshi Ide, Keizo Tano, Tadayoshi Bessho. SPRTN and TDP1/TDP2 independently suppress 5-aza-2’-deoxycytidine induced genomic instability in human TK6 cell line. Chemical research in Toxicology. 2022. 35. 11. 2059-2067
Toshiaki Nakano, Ken Akamatsu, Masataka Tsuda, Ayane Tujimoto, Ryoichi Hirayama, Takeshi Hiromoto, Taro Tamada, Hiroshi Ide, Naoya Shikazono. Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: visualization and analysis with atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 13. e2119132119
Mahmoud shoulkamy, Toshiaki Nakano, Hiroshi Ide. Molecular insights into the repair mechanism of enzymatic DNA-protein cross-link damage induced by a DNMT inhibitor. International Journal of Cancer and Biomedical Research. 2021. 5. 4. 13-23

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MISC (14)：

赤松憲, 中野敏彰. 電離放射線による DNA損傷の特徴と修復について ~細胞にとってハイリスクな損傷とは~. 日本原子力学会誌. 2023
中野敏彰, 赤松憲, 鹿園直哉. 放射線照射によって生じたDNA損傷の構造解析と修復速度. 放射線化学. 2023. 116. 15-19
Toshiaki Nakano, Mahmoud Shoulkamy, Masataka Tsuda, Hiroyuki Sasanuma, Shin-ichiro Masunaga, Shunichi Takeda, Hiroshi Ide, Tadayoshi Bessho, Keizo Tano. How does TDP1 exert in DNA-protein cross-links repair mechanism?. ACEM/JEMS 2019. 2019
Masataka Tsuda, Kaito Kitamasu, Toshiaki Nakano, Hiroshi Ide. Repair of topoisomerase2 covalent cleavage complexes by tyrosyl-DNA phosphodiesterase 2(TDP2). The Joint Meeting of The 6th Asian Congress on Environmental Mutagenes (ACEM) and The 48th Annual Meeting of the Japanese Environmental Mutagen Society (JEMS). 2019
Amir M.H, Kawaida T, Miyamoto-Matsubara M, Nakano, T, Ide H. Analysis of a damage-tolerance mechanism for DNA-protein cross-links. Nucleic Acids Symp. Ser. 2012

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Books (1)：

Formation, Repair, and Biological Effects of DNA-Protein Cross-Link Damage
Advances in DNA Repair 2015

Lectures and oral presentations (15)：

Visualization and Biological Iufluences of High-Density DNA Cluster Damage and DNA-protein crosslink damages
(第12回日本放射線事故・災害医学会年次学術集会 (京大放生研シンポジウム) 2024)
放射線で生じる高密度DNA損傷及びDNA付加体損傷の可視化とその生物影響
(2024)
放射線により生じる高複雑度のDNA損傷の可視化と修復機構の解明
(令和5年度日本放射線影響学会第66回大会 2023)
Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: visualization and analysis with atomic force microscopy
(2022年度大阪ニュークリアサイエンス協会受賞公演 2023)
放射線照射により生じるDNA損傷の顕微鏡を用いた可視化方法の確立
(放射線衛生管理学研究室カンファレンス2022, 産業医科大学 2023)

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Professional career (1)：

博士 (理学)

Work history (8)：

2024/07 - 現在国立研究開発法人量子科学技術研究開発機構関西光量子科学研究所量子応用光学研究部照射細胞応答研究プロジェクト
2024/04 - 2024/06 国立研究開発法人量子科学技術研究開発機構関西光量子科学研究所量子応用光学研究部照射細胞応答研究プロジェクト主幹研究員
2021/04 - 2024/03 国立研究開発法人量子科学技術研究開発機構量子生命・医学部門量子生命科学研究所 DNA損傷化学研究グループ
2018/07 - 2021/03 National institute for Quantum and Radiation Science and Technology Radiation DNA Damage ResearchaGroup
2008/08 - 2018/06 Hiroshima University Graduate School of Science 助教

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Awards (7)：

2025/03 - 国立研究開発法人量子科学技術研究開発機構創意工夫功労賞細胞死を引き起こすDNAの重篤な傷の修復方法の特定
2023/06 - 一般社団法人大阪ニュークリアサイエンス協会 (ONSA) 大阪ニュークリアサイエンス協会賞(ONSA賞) Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: visualization and analysis with atomic force microscopy
2022/03 - 量子科学技術研究開発機構創意工夫功労賞細胞内DNA損傷の可視化技術の開発
2008 - 10th International Workshop on Radiation Damage to DNA Young investigator awards
2008 - 財団法人井上科学振興財団 24th Inoue Research Award for Young Scientists

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