Yamamoto Masayuki

• 2021 - 2026 Regulation of signal transduction via crosstalk between supersulfide and selenium
• 2019 - 2024 Deciphering Molecular Basis for the Anti-Oxidative Stress Response and Application of the Basis for Disease Prevention and Therapy
• 2019 - 2020 生体の酸化ストレス応答の分子メカニズム解明とその疾病予防・治療への応用
• 2018 - 2020 Elucidation of cytoprotective mechanisms by structural analysis of stress sensor Keap1
• 2015 - 2019 Promotion of oxygen biology on the basis of international networks
2015 - 2019 Mechanisms of leukemogenesis by the leukemia-driving enhancer
2014 - 2019 Oxygen biology: a new criterion for integrated understanding of life
2014 - 2019 Systemic mechanisms of response to hypoxic stresses
2015 - 2018 Mecahistic analysis of a protective response of skin tissue to UV genotoxicity
2015 - 2017 The role of Nrf2 in development and carcinogenesis of NASH using gene rescue mice
2014 - 2017 Elucidation of the mechanism of epithelial stem cell niche and its reproduction
2014 - 2017 The role of Nrf2 in oxidative stress-mediated insulin resistance
2014 - 2017 Search for novel physiological function of transcriptional factor Nrf2
2014 - 2017 The regulatory role of Nrf2 in pathogenesis and carcinogenesis of NASH using gene rescued mice
2014 - 2016 The role of Nrf2 in pancreatic beta-cells; a study of new pancreatic beta-cell specific Nrf2 activation model mice
2014 - 2016 Identification of leukemia-initiating cells in an inv(3)(q21q26) mouse model
2012 - 2015 Roles of stress-responsive transcription factors in health and disease
2010 - 2015 Crosstalk between chromosome modification and transcription factors in the differentiation of hematopoietic cells
2012 - 2014 Analysis of leukemogenesis caused by disruption of gene regulatory mechanisms mediated by multiple transactivation domains
2011 - 2011 Mechanism of Nrf2-mediated self-renewal of hematopoietic stem cells
2010 - 2011 The role of Keap1-Nrf2 system in oxidative stress response of pancreatic β-cells
2010 - 2011 The functional analysis of a transcriptional factor GATA3 in an inner ear development.
2009 - 2011 Novel prevention of development of life style-related liver diseases and liver carcinogenesis through an activation of transcription factor induced by functional foods
2007 - 2011 Molecular Mechanisms of Adaptive Responses to Food and Oxygen
2010 - 2010 転写因子Nrf1の神経細胞恒常性維持機構の解明
2007 - 2009 From the ER to the plasma membrane : Vesicular transport of membrane skeleton units and the diseases
2005 - 2009 Roles of transcription factors for carcinogenesis and carcinogenesisdefense
2004 - 2009 Genetic and Epigenetic Dysregulation in Cancer
2006 - 2007 転写因子の発現量依存的な細胞運命決定機構の解明
2005 - 2007 動脈硬化の進行防止における転写因子Nrf2の役割
2005 - 2006 Study for the molecular mechanism of oxidative stress responsive transcription
2004 - 2006 Molecular pathology for down-regulation of erythroid-specific genes in prion diseases
2004 - 2005 Gene manipulation of hypoxia inducible gene regulation
2003 - 2004 Molecular mechanisms for hemato-vascular formation
2003 - 2004 Transcription factor regulation of malignant cell transformation and its repression
2002 - 2004 Analysis of lymph node metastasis of oral cancer by using peroxiredoxin I knockout mouse
2002 - 2004 Sensitive detection of air-born mutagens and their evaluation using gene knockout mice
2000 - 2004 転座関連遺伝子及び転写因子による細胞分化とがん化の分子機構
2002 - 2003 分化方向性の制御から挑む再生医工学
2002 - 2003 Molecular mechanisms for the assembly of the red cell membrane skeleton during erythroid cell development
2002 - 2003 赤芽球の増殖・分化・アポトーシスの制御におけるGATA因子の役割の解明
2001 - 2003 Gene Modification of Oxygen Responsiveness by Erythropoietin Gene
2001 - 2003 Construction of a repertoire of genetically altered mice for evaluating the toxicity of chemicals
2002 - 2002 転写制御複合体形成のダイナミクスとその生物機能の解明
2001 - 2002 Investigation of biological function of thioredoxin by construction of thioredoxin knock down mice
2001 - 2002 Functional Contribution of Small Maf Proteins in Hematopoietic Cells
2001 - 2002 Functional analysis of BTEB and BTEB2 transcription factors by gene-targeting technology
2000 - 2001 APPLICATION OF GENE MANIPULATION TECHNOLOGY TO GENERATION OF MODEL ANIMALS FOR ENVIRONMENTAL ASSESSMENT
2000 - 2001 Development of monitoring system of toxic chemicals base on the Nrf2-dependent detoxification pathway
2000 - 2001 Molecular mechanism for the assembly of red cell membrane skeletons based on pathobiology of congenital hemolytic anemia in cattle
2000 - 2001 Analysis of biological function of regulatory network composed of bZip transcription factors
1999 - 2001 Study on a new defence system against oxidative stress
1998 - 2001 転写調節による造血分化制御
1997 - 2001 Transcriptional mechanisms controlling organized function in vertebrate
1999 - 2000 Nrf2による新しい酸化ストレス応答機構の解析
1999 - 2000 Function of bridging molecules in enhancer-promoter communication during erythropoieis
1999 - 2000 Analysis of GATA transcription factors functions on development and differentiation of hematopoietic cells.
1997 - 2000 Target genes and biological role of transcription factors in animal
1999 - 1999 血液細胞の分化と機能発現の制御機構の解明
1998 - 1999 Gene manipulation of heme synthetic pathway enzymes
1998 - 1999 Applications of Tissue-specific Transcription Factor in Animal Gene Therapy
1997 - 1999 Regulation and Function of Erythroid Transcription Factors.
1997 - 1998 小Maf群転写因子を用いた形質転換細胞の分化誘導
1997 - 1998 エリスロポエチン遺伝子の発現調節機構の解析
1997 - 1998 Development of New Therapeutic Strategy for Autoimmune Diseases through Gene Introduction of Oncogene c-maf.
1997 - 1998 Regulation of Disease Susceptibility through Gene Introduction of Transcriptiom Factors.
1997 - 1998 GENETIC CONTROL OF HEMATOPOIETIC CELL DOFFERENTIATION
1994 - 1998 Purification and ampliefication of hematopoietic stem cells
1996 - 1997 Transcription factors regulating the erytnroid and megakaryocytic cell differentiation.
1995 - 1997 Molecular Mechanism of Erythroid Differentiation
1996 - 1996 高等動物細胞の遺伝子発現における転写因子の相互作用と生物作用の分子機構
1996 - 1996 生殖細胞と支持細胞の機能的連関とGATA転写因子群
1996 - 1996 細胞の機能分化に関わる遺伝子制御ネットワーク-転写因子間相互作用-
1995 - 1996 Possible involvement of vascular cells-related transcription factors in human inflammatory diseases and cancer tissue.
1995 - 1996 Multiple transcription factors regulation of erythroid cell differeutiation mechanisms.
1994 - 1996 Cooperation and information exchange with European countries.
1995 - 1995 生殖細胞と支持細胞の機能的関連とGATA転写因子群
1995 - 1995 赤血球系転写因子群とMaf関連蛋白質による赤血球分化の制御とその異常の解析
1995 - 1995 転写因子群による赤血球特異的な遺伝子発現制御機序の解析
1994 - 1994 GATA転写因子群による細胞特異的転写調節機序の解析
1994 - 1994 癌遺伝子mafの関連遺伝子産胸による赤血球系転写因子NF-E2の機能変換
1994 - 1994 細胞分化の決定と癌遺伝子の役割
1994 - 1994 転写因子群による赤血球特異的な遺伝子発現調節機序の解析
1993 - 1994 Molecular analyzes of heme regulation and its disorders.
1993 - 1993 食道癌に発現する増殖因子の検討-食道癌の増殖の特性と悪性度に関連して-
1993 - 1993 GATA転写因子群をコードする遺伝子の構造と発現調節機序の解析
1993 - 1993 ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髄性プロトポルフィリン症
1993 - 1993 細胞分化の決定と癌遺伝子の役割
1992 - 1993 Analysis of the erythroid-specific gene expression by GATA trenscription factors
1992 - 1993 Structure and function of the regulatory region of the gene encoding non-specific form delta-aminolevulinate synthase
1992 - 1993 細胞分化の決定と癌移伝子の役割
1992 - 1992 ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髄性プロトポルフィリン症
1991 - 1991 ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髓性プロトポルフィリン症
1991 - 1991 転写因子GATA(NF-EI)群をコ-ドする遺伝子の構造と発現調節機序の解析
1987 - 1988 Coupled Expression of The Genes Encoding The Constituents of The Glycine Cleavage System in Chicken

• Kinuko Ohneda, Yoichi Suzuki, Yohei Hamanaka, Shu Tadaka, Muneaki Shimada, Junko Hasegawa-Minato, Masanobu Takahashi, Nobuo Fuse, Fuji Nagami, Hiroshi Kawame, et al. Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan. Journal of human genetics. 2025
• Naoko Mori, Shunji Mugikura, Atsushi Hozawa, Makiko Taira, Hiroaki Hashizume, Atsushi Sekiguchi, Mitsunari Abe, Michiyo Kasai, Tomo Saito, Kengo Kinoshita, et al. Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project. The Tohoku journal of experimental medicine. 2025
• Akihiko Shiraki, Atsushi Hirayama, Nobuo Fuse, Ryo Kawasaki, Satoko Fujimoto, Tomoyuki Okazaki, Susumu Sakimoto, Takatoshi Maeno, Makiko Taira, Tomo Saito, et al. Prevalence and Associations of Epiretinal Membrane by OCT in a Japanese Population-Based Cohort: Tohoku Medical Megabank Organization Eye Study. Ophthalmology science. 2025. 5. 4. 100752-100752
• Keiko Murakami, Misako Nakadate, Taku Obara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisashi Ohseto, Noriyuki Iwama, Masatoshi Saito, et al. Validity of a self-administered food frequency questionnaire for genomic and omics research among pregnant women: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of epidemiology. 2024
• Makiko Taira, Nobuo Fuse, Andrew J Saykin, Fuji Nagami, Kengo Kinoshita, Masayuki Yamamoto. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. 20 Suppl 1. e093405

ｍore...

• 布施昇男, 安澤隼人, 元池育子, 櫻井美由紀, 木下賢吾, 山本雅之. Genome-wide association study of central corneal thickness in the cohort Study. 日本眼科学会雑誌. 2024. 128
• 伊藤ゆり, 井澤武史, 濱田菜々子, 田中美有, 田口恵子, 田口恵子, 山本雅之, 桑村充. Study on the activation of Nrf2 system in thioacetamide-induced GSTp-positive hepatocyte foci. 日本毒性病理学会総会及び学術集会講演要旨集. 2024. 40th
• 押切裕之, 押切裕之, 田口恵子, 谷山裕亮, 山本雅之, 亀井尚. 食道扁平上皮癌細胞におけるNRF2とNQO1の発現とゲルダナマイシン誘導体の増殖抑制. 日本食道学会学術集会抄録集(CD-ROM). 2024. 78th
• 内田新菜, 中井琢, 福内友子, 山岡法子, 小柴生造, 山本雅之, 鈴木教郎, 三枝大輔, 三枝大輔. Metabolic profiling of plasma and urine for the daprodustat treatment mice by GC-MS/MS. 日本薬学会年会要旨集(Web). 2024. 144th
• 佐藤和, 藤原和樹, 長尾健児, 今泉明, 小柴生造, 佐藤允治, 元池育子, 木下賢吾, 山本雅之. 海馬周辺の脳容積値と関連する血中メタボロームの探索. Dementia Japan. 2023. 37. 4

ｍore...

• Molecular Basis of Keap1-Nrf2 System Regulation of Inflammation
  (1st Nature Immunology - Cellular & Molecular Immunology Joint Conference 2015)
• Keap1-Nrf2制御系の分子基盤と疾患
  (日本ケミカルバイオロジー学会 第10回年会 2015)
• Renal erythropoietin producing cells for anemia and fibrosis
  (10th International Luebeck EPO Conference 2015)
• 東日本大震災からの創造的復興と東北メディカル・メガバンクプロジェクト
  (第69回日本交通医学会総会 2015)
• 酸化ストレスと生体防御機構ー消化器疾患におけるNrf2とKeap1の役割
  (第101回日本消化器病学会 2015)

ｍore...

• 2023/11 - Highly Cited Researcher for 2023, Clarivate Analytics
• 2023/06 - Society for Free Radical Research-Europe Annual Research Award 2023
• 2023/03 - 安藤スポーツ・食文化振興財団 安藤百福賞 優秀賞 植物栄養素ファイトケミカルによる抗酸化生体防御作用の分子メカニズム解明
• 2022/11 - Clarivate Analytics Highly Cited Researcher for 2022
• 2022/06 - University of Eastern Finland Honorary Doctorate
2021/11 - Clarivate Analytics Highly Cited Researcher for 2021
2021/08 - ISS Research Conference ISS Research Award for Dr Masayuki Yamamoto and MHU-3 Mission Team “Compelling Results in Biology and Medicine for their work on Nrf2 and the ToMMo project“
2021/03 - Society for Free Radical Research Lester Packer Award
2021/01 - 河北文化事業団 河北文化賞「生体の酸化ストレス応答機構の解明」
2020/11 - Clarivate Analytics Highly Cited Researcher for 2020
2020/06 - Federation of Asia and Oceania Biochemists and Molecular Biologists (FAOBMB) FAOBMB Research Excellence Award
2019/11 - Clarivate Analytics Highly Cited Researcher for 2019
2018/11 - Clarivate Analytics Highly Cited Researcher for 2018
2017/12 - 日本生化学会 柿内三郎賞 環境ストレス応答機構の発見とその生理的・病理的意義の解明
2016/06 - 日本毒性学会 特別賞 Keap1-Nrf2制御システムの発見による毒性学への貢献
2014/07 - 日本学士院 the Japan Academy Prize 生体の環境ストレス応答の分子機構の解明
2013/07/01 - 第一三共生命科学研究振興財団 高峰記念第一三共賞 環境ストレスに対する生体応答メカニズムの解明
2013/06/07 - 日本腎臓財団 日本腎臓財団学術賞 エリスロポエチン産生の制御機構に関する研究
2012/06 - Oxygen Club of California Oxygen Club of California and Jarrow Formulas Health Sciences Prize
2012/04 - 日本国 Medal with purple ribbon
2012/03 - 上原記念生命科学財団 上原賞 酸素や食物が内包する毒性に対する生体の応答機構の解明
2011/03 - Society of Toxicology Leading Edge in Basic Science Award
2011/03 - 東レ科学振興会 東レ科学技術賞 生体の環境ストレス応答の分子機構の解明
2008/05/21 - 日産科学振興財団 日産科学賞 環境適応・応答の分子機構の解明
2007/09/27 - 茨城県科学振興財団・つくばアカデミー つくば賞 環境応答の分子機構の解明
2004/11 - Thomson Scientific Co. Thomson Scientific Research Front Award 2004
1996/02 - 井上科学振興財団 井上学術賞 「転写因子群による赤血球特異的遺伝子発現制御機構の解析」
1995/01 - 東北大学医学部 東北大学医学部奨学賞・金賞および坂田賞 「転写因子による細胞・組織特異的遺伝子発現調節機序の解明」

日本分子生物学会(2001/10- 評議員) ,  日本癌学会(2000/10- 評議員) ,  特定研究(A)転写調節機構(1997/10-2000/10 統括幹事) ,  日本生化学会(2006/04- 理事) ,  日本生化学会(2000/10-2004/04 代議員) ,  日本生化学会(1996/10- 評議員) ,  アメリカ血液学会(ASH)(1998/10-) ,  アメリカ生化学・分子生物学会(ASBMB)(1998/10-) ,  日本発生生物学会(1993/10-) ,  日本癌学会(1990/01-) ,  日本血液学会(1990/10-) ,  日本分子生物学会(1989/10-) ,  マメリカ微生物学会(ASM)(1984/10-) ,  日本生化学会(1979/04-)