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J-GLOBAL ID：200901033403078046 Update date: Mar. 24, 2025

Kobayashi Hiroya

コバヤシヒロヤ | Kobayashi Hiroya

Research field (3)： Immunology , Experimental pathology , Human pathology

Research theme for competitive and other funds (14)：

2023 - 2026 頭頸部癌特異的T細胞を活用した複合型免疫療法の開発
2022 - 2025 cGAS/STING/I型IFN経路を基軸とした癌免疫微小環境のホット化治療戦略
2022 - 2025 cGAS/STING/I型IFN経路を基軸とした癌免疫微小環境のホット化治療戦略研究課題
2019 - 2022 Epithelial mesenchymal transition (EMT)-associated proteins as potent immunotherapeutic target for canner immunotherapy
2016 - 2018 Analysis of stealth antigens for developing tumor immunotherapy

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Papers (93)：

Risa Wakisaka, Hidekiyo Yamaki, Michihisa Kono, Takahiro Inoue, Ryosuke Sato, Hiroki Komatsuda, Kenzo Ohara, Akemi Kosaka, Takayuki Ohkuri, Toshihiro Nagato, et al. Hypoxia-Targeted Immunotherapy with PD-1 Blockade in Head and Neck Cancer. Cancers. 2024. 16. 17
Kono M., Wakisaka R., Komatsuda H., Hayashi R., Kumai T., Yamaki H., Sato R., Nagato T., Ohkuri T., Kosaka A., et al. Immunotherapy targeting tumor-associated antigen in a mouse model of head and neck cancer. Head Neck. 2024. 46. 8. 2056-2067
Aiko Murai, Terufumi Kubo, Takayuki Ohkuri, Junko Yanagawa, Yuki Yajima, Akemi Kosaka, Dongliang Li, Toshihiro Nagato, Kenji Murata, Takayuki Kanaseki, et al. NF9 peptide specific cytotoxic T lymphocyte clone cross react to Y453F mutation of SARS-CoV-2 virus spike protein. Immunological medicine. 2024. 47. 2. 93-99
Toshihiro Nagato, Hiroki Komatsuda, Ryusuke Hayashi, Miki Takahara, Nanami Ujiie, Akemi Kosaka, Takayuki Ohkuri, Kensuke Oikawa, Ryosuke Sato, Risa Wakisaka, et al. Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27 interaction in nasopharyngeal carcinoma. Cancer science. 2024. 115. 4. 1073-1084
Yuki Yajima, Akemi Kosaka, Takayuki Ohkuri, Yoshihiko Hirohashi, Dongliang Li, Takeshi Nagasaki, Toshihiro Nagato, Toshihiko Torigoe, Hiroya Kobayashi. SARS-CoV-2 spike protein-derived immunogenic peptides that are promiscuously presented by several HLA-class II molecules and their potential for inducing acquired immunity. Heliyon. 2023. 9. 9. e20192

MISC (20)：

Takayuki Ohkuri, Akemi Kosaka, Yuki Yajima, Shunsuke Yasuda, Hiroki Komatsuda, Toshihiro Nagato, Kensuke Oikawa, Hiroya Kobayashi. Analysis for myeloid cells increased in tumor-draining lymph nodes after intratumoral STING activation. CANCER SCIENCE. 2023. 114. 906-906
Akemi Kosaka, Takayuki Ohkuri, Yuki Yajima, Shunsuke Yasuda, Hiroki Komatsuda, Toshihiro Nagato, Kensuke Oikawa, Hiroya Kobayashi. Investigation of the ability of inducing type I IFNs in the tumor microenvironment. CANCER SCIENCE. 2023. 114. 1168-1168
Yuki Yajima, Takayuki Ohkuri, Shunsuke Yasuda, Hiroki Komatsuda, Toshihiro Nagato, Kensuke Oikawa, Hiroya Kobayashi. Verify the significance of FXYD3 as a biomarker in oral squamous cell carcinoma from the signal pathway. CANCER SCIENCE. 2023. 114. 1487-1487
Shunsuke Yasuda, Hiroki Komatsuda, Yuki Yajima, Akemi Kosaka, Toshihiro Nagato, Takayuki Ohkuri, Kensuke Oikawa, Masahiro Kitada, Hiroya Kobayashi. Intratumoural administration of colchicine induces anti-tumour immunity by type I interferons. CANCER SCIENCE. 2023. 114. 384-384
大栗敬幸, 小坂朱, 小林博也. がんの免疫逃避を打破する治療法の開発. バイオサイエンスとインダストリー. 2022

Patents (7)：

Lectures and oral presentations (211)：

FXYD3が口腔扁平上皮癌の新たなバイオマーカーとなり得るかの検証
(第69回日本口腔外科学会総会 2024)
高肺転移性トリプルネガティブ乳癌マウスモデルにおけるI型IFN応答分子の検討
(第57回北海道病理談話会 2024)
NOD刺激はNF-kBの活性化を介してSTING刺激を増強する
(第57回北海道病理談話会 2024)
The involvement of type I IFN-responding molecules in lung metastasis of a triple-negative breast cancer mouse model
(第83回日本癌学会学術総会 2024)
Effects of tumor-derived IL-6 on the tumor microenvironment and anti-tumor immune responses
(第83回日本癌学会学術総会 2024)

Education (4)：

Professional career (1)：

Work history (1)：

Awards (1)：

Association Membership(s) (3)：

日本病理学会 , 日本癌学会 , 日本免疫学会

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