Rchr
J-GLOBAL ID：200901035399825128
Update date: Sep. 24, 2024
Tomaru Utano
トマル ウタノ | Tomaru Utano
Affiliation and department：
Homepage URL (1)：
http://www.med.hokudai.ac.jp/~patho-1w/
Research field (1)：
Experimental pathology
Research keywords (3)：
病理学
, 免疫学
, 実験病理学
Research theme for competitive and other funds (18)：
- 2022 - 2026 Inflammagingにおける炎症・老化細胞の解析とバイオマーカーへの展開
- 2021 - 2024 Reveal of the pathogenesis of MPO-ANCA-associated vasculitis and development of novel therapeutic strategies
- 2020 - 2022 Analysis of inflammatory cells in age-related chronic inflammation
- 2018 - 2022 Molecular pathology of autoreactive inflammatory T cells
- 2015 - 2017 Involvement of neutrophil extracellular traps in the development of diabetic angiopathy
- 2014 - 2017 Basic and clinical strategy to overcome microscopic polyangiitis
- 2013 - 2016 The role of proteasome in pulmonary fibrosis
- 2013 - 2016 Dysfunction of proteasome and pathogenesis in age-related disorders
- 2013 - 2016 Analysis of retinal degeneration caused by dysfunction of ubiquitin proteasome system
- 2010 - 2012 Development of regenerative medicine for spinal cord injury in HTLV-1 associated myelopathy
- 2010 - 2012 Proteasomal dysfunction and pathology
- 2008 - 2010 Pathogenesis of vasculitis and novel diagnostic and therapeutic strategies
- 2007 - 2008 Role of stress-inducible NKG2D ligands in disease
- 2005 - 2006 慢性ウイルス感染症におけるメモリーT細胞の免疫応答と関連疾患の病態解明
- 2005 - 2006 MILL分子群による免疫監視機構の解析
- 2003 - 2004 EXPRESSION OF HUMAN ENDOGENOUS RETROVIRUS AND ITS POSSIBLE ROLES FOR DEVELOPING AUTOIMMUNE DESIASES
- 2003 - 2003 動物モデルを用いたHTLV-1発がん機構の解析
- 2002 - 2003 Development and analyses of novel animal models for human retrovirus-induced desiases.
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Papers (203)：
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Shimpei Nakagawa, Aya Fukui-Miyazaki, Takuma Yoshida, Yasushi Ishii, Eri Murata, Koji Taniguchi, Akihiro Ishizu, Masanori Kasahara, Utano Tomaru. Decreased Proteasomal Function Exacerbates Endoplasmic Reticulum Stress-Induced Chronic Inflammation in Obese Adipose Tissue. The American journal of pathology. 2024. 194. 6. 1033-1046
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Yusho Ueda, Daigo Nakazawa, Saori Nishio, Satoka Shiratori-Aso, Takashi Kudo, Atsuko Miyoshi-Harashima, Kanako Watanabe-Kusunoki, Fumihiko Hattanda, Sari Iwasaki, Takahiro Tsuji, et al. Transcription factor Nrf2 activation regulates NETosis, endothelial injury, and kidney disease in myeloperoxidase-positive antineutrophil cytoplasmic antibody-associated vasculitis. Kidney international. 2024
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Tomohisa Baba, Utano Tomaru, Atsushi Hirao, Naofumi Mukaida, Yoshikazu Johmura. Autophagy inhibition-induced cytosolic DNA sensing combined with differentiation therapy induces irreversible myeloid differentiation in leukemia cells. Cancer research communications. 2024
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Hodaka Ogawa, Shunichi Yokota, Yumeka Hosoi, Ayano Shindo, Naho Ogawa, Ryodai Yamamura, Tomohiro Shimizu, Issei Nakade, Suishin Arai, Mai Taniguchi, et al. Methylprednisolone pulse-enhanced neutrophil extracellular trap formation in mice with imiquimod-induced lupus-like disease, resulting in ischaemia of the femoral head cartilage. Lupus science & medicine. 2023. 10. 2
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Issei Nakade, Yuto Tamura, Fuyu Hashimoto, Yuko Ariza, Shingo Hotta, Hirofumi Fujigaya, Suishin Arai, Mai Taniguchi, Hodaka Ogawa, Yuka Nishibata, et al. Bruton's tyrosine kinase is a possible therapeutic target in microscopic polyangiitis. Arthritis research & therapy. 2023. 25. 1. 215-215
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MISC (213)：
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川上民裕, 中出一生, 田村宥人, 伊藤吹夕, 西端友香, 益田紗季子, 外丸詩野, 石津明洋. 皮膚血管炎動物モデルの完成. 脈管学(Web). 2023. 63. 1
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川上民裕, 中出一生, 田村宥人, 西端友香, 益田紗季子, 石津明洋, 伊藤吹夕, 外丸詩野. 正常ラットに抗PSPT抗体と抗LAMP2抗体の静脈注射により皮膚血管炎の発症に成功した. 日本皮膚科学会雑誌. 2023. 133. 3
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新海隼人, 加藤千恵次, 川上民裕, 高橋啓, 西端友香, 益田紗季子, 田中敏, 外丸詩野, 石津明洋. 人工知能による結節性多発動脈炎と皮膚動脈炎の皮膚生検画像の鑑別. 脈管学(Web). 2021. 61. 1
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西端友香, 益田紗季子, 外丸詩野, 石津明洋. myosin light chain6を認議する抗好中球細胞外トラップ(NETs)抗体はNETs分解阻害活性を持つ. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2021. 65th
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益田紗季子, 西端友香, 田中敏, 外丸詩野, 辻野一三, 石津明洋. Effects of hypoxia on neutrophil extracellular trap formation. 日本病理学会会誌. 2021. 110. 1
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Professional career (1)：
Work history (3)：
- 2012/11 - 現在 北海道大学大学院 医学研究院 分子病理学教室 准教授
- 2004/11 - 2012/10 北海道大学大学院 医学研究院 分子病理学教室 講師
- 2003/04 - 2004/10 北海道大学大学院 医学研究院 分子病理学教室 助教
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