Shimomura Yoshiharu

Homepage URL (1)： http://www.agr.nagoya-u.ac.jp/~nutr/shimomura/index.html

Research field (1)： Food sciences

Research keywords (3)： Kestose , BCAA , Branched-chain amino acids

Research theme for competitive and other funds (24)：

2020 - 2024 Mechanisms responsible for skeletal muscle atrophy induced by vitamin D deficiency
2017 - 2020 Physiological functions of branched-chain amino acids as regulatory factors in mammals
2014 - 2017 Mechanism of amino acid metabolism, alleviation and prevention of hepatic steatosis
2014 - 2017 Physiological functions of branched-chain amino acids as regulatory factors in mammals
2014 - 2016 Amino acid nutrition for promoting the efficacy of exercise training

2013 - 2016 Analysis of lipotoxicity induced by fatty acids

2012 - 2014 Physiological functions of free branched-chain amino acids in nerve and brain

2010 - 2011 PHYSIOLOGICAL FUNCTIONS OF BRANCHED-CHAIN AMINO ACIDS IN MUSCLES

2008 - 2010 Effects of amino acid administration and exercise on the regulation of the muscle protein and energy metabolism.

2008 - 2009 肝硬変および癌における代謝状態の改善に関する研究

2005 - 2007 Effects of amino acid supplementation and exercise on muscle protein synthesis

2003 - 2004 Differences in mechanism of regulatory system on energy metabolism between regenerating liver and hepatocellular carcinoma

2003 - 2004 Role of PPAR-α on human liver metabolic dysfunction and carcinogenesis

2002 - 2004 Study on the mechanisms responsible for improvement of glucose, lipid, and amino acid metabolism.

1999 - 2001 Study on the mechanisms responsible for improvements of glucose and amino acid metabolism by exercise

1999 - 2000 Studies of glucose metabolism in human liver disease-influence by mRNA expression for pyruvate dehydrogenase kinase and phosphatse-

1997 - 1998 Relationship of expression of c-myc and branched-chain aminotransferase in human gastric cancer cells and tissues

1996 - 1997 Study on the dietary protein beneficial to the protein synthesis in exercise-trained muscle in rat.

1996 - 1997 EFFECTS OF CIRRHOTIC LIVER ON MITOCHONDRIAL REPLICATION AND TRANSCRIPTION

1995 - 1995 ヒト肝臓におけるバリン代謝の調節:肝硬変による代謝異常のメカニズム

1994 - 1994 ヒト肝臓におけるバリン代謝の調節:肝硬変の影響

1992 - 1992 体重の増減の繰り返しが体組成に及ぼす影響とそれに対する運動の効果

1991 - 1991 運動トレ-ニングによる筋ミトコンドリア増加のメカニズムに関する生化学的研究

1988 - 1988 ミトコンドリア膜のリン脂質と電子伝達系酵素の相互作用

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Papers (79)：

Kento KURAMITSU, Yoshihiro KADOTA, Ayako WATANABE, Akihito ENDO, Yoshiharu SHIMOMURA, Yasuyuki KITAURA. The Effects of 1-Kestose on the Abundance of Inflammation-Related Gene mRNA in Adipose Tissue and the Gut Microbiota Composition in Rats Fed a High-Fat Diet. Journal of Nutritional Science and Vitaminology. 2024. 70. 4. 311-317
倉満健人, 久保尊, 門田吉弘, 下村吉治, 北浦靖之. 高タンパク質食摂取時の腸内アミノ酸発酵と1-ケストースの影響. 日本栄養・食糧学会大会講演要旨集. 2024. 78回. 196-196
Shuji Ikegami, Masanao Nakamura, Takashi Honda, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Eri Ishikawa, Kenta Yamamoto, Satoshi Furune, Takuya Ishikawa, et al. Efficacy of 1-kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double-blind, placebo-controlled pilot study. Alimentary pharmacology & therapeutics. 2023. 57. 11. 1249-1257
Naoya Nakai, Noriko Iida, Saki Kitai, Yoshiharu Shimomura, Yasuyuki Kitaura, Kazuhiko Higashida. BDK knockout skeletal muscle satellite cells exhibit enhanced protein translation initiation signal in response to BCAA in vitro. Bioscience, biotechnology, and biochemistry. 2022. 86. 5. 610-617
Naofumi Yoshida, Tomoya Yamashita, Tatsunori Osone, Tetsuya Hosooka, Masakazu Shinohara, Seiichi Kitahama, Kengo Sasaki, Daisuke Sasaki, Takeshi Yoneshiro, Tomohiro Suzuki, et al. Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity. iScience. 2021. 24. 11. 103342-103342

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MISC (8)：

Yasuyuki Kitaura, Yoshiharu Shimomura. Importance of the regulation of branched-chain amino acid metabolism. Seikagaku. 2018. 90. 2. 234-237
門田吉弘, 高橋基毅, 神尾里奈, 栃尾巧, 遠藤明仁, 北浦靖之, 下村吉治. 1-ケストースによる腸内環境への影響. 日本栄養・食糧学会大会講演要旨集. 2017. 71回. 249-249
Yoshiharu Shimomura, Yusuke Kondo, Rina Ito, Ai Tsuji, Katsumi Shibata, Yasuyuki Kitaura. Novel mechanism responsible for regulation of branched-chain alpha-ketoacid dehydrogenase kinase. FASEB JOURNAL. 2016. 30
畑澤幸乃, 妹尾奈波, 北浦靖之, 下村吉治, 三浦進司, 亀井康富. 運動時の骨格筋でのPGC1αを介したアミノ酸代謝の役割. アミノ酸研究. 2016. 9. 2. 117-117
Hideki Matsumoto, Keiichi Akita, Ryosei Sakai, Yoshiharu Shimomura. Analysis of Branched-Chain alpha-Keto Acid Dehydrogenase Complex (BCKDC) Activity and Activity State in Rat Skeletal Muscle by Isotope Ratio Mass Spectrometry (IRMS) using C-13-Labeled Stable Isotope Substrate. FASEB JOURNAL. 2009. 23

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Professional career (1)：

医学博士 (名古屋大学)

Work history (7)：

2019/04 - 現在 Chubu University College of Bioscience and Biotechnology, Department of Food and Nutritional Sciences Professor
2008/08 - 2019/03 Nagoya University Graduate School of Bioagricultural Sciences Department of Applied Biosciences Professor
2003/04 - 2008/07 Nagoya Institute of Technology Graduate School of Engineering Professor
1997/05 - 2003/03 Nagoya Institute of Technology Faculty of Engineering Professor
1992/04 - 1997/04 Nagoya Institute of Technology Faculty of Engineering Associate Professor

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Awards (4)：

2023/05 - 公益社団法人日本栄養・食糧学会日本栄養・食糧学会功労賞
2018/04 - 公益財団法人飯島藤十郎記念食品科学振興財団飯島藤十郎食品技術賞
2011/05 - 公益社団法人日本栄養・食糧学会日本栄養・食糧学会学会賞
2001/05 - Ajinomoto Award BCAA基礎研究賞

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