Rchr
J-GLOBAL ID:200901036145308243
Update date: Aug. 31, 2024
Takahashi Masahide
タカハシ マサヒデ | Takahashi Masahide
Affiliation and department:
Job title:
Director, Designated Professor
Other affiliations (1):
Research field (1):
Experimental pathology
Research keywords (9):
neurogenesis
, angiogenesis
, receptor tyrosine kinase
, neurotrophic factor
, enteric nervous system
, neuronal differentiation
, invasion and metastasis of cancer cells
, cell growth
, cancer
Research theme for competitive and other funds (45):
- 2020 - 2023 がんの線維化におけるMeflinの機能解析と新規治療法の開発研究
- 2019 - 2022 Functional analysis of CD109 in tumor progression using osteosarcoma cells and tissue
- 2014 - 2019 Girdinファミリー分子の機能と精神神経疾患・がんの病態形成における役割
- 2013 - 2017 Phosphoproteomic analysis of RET kinase signal in MTC model mice
- 2014 - 2016 Molecular Mechanisms of Collective Migration of Cancer Cells
- 2010 - 2016 Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation
- 2010 - 2015 Modification of an actin binding protein Girdin by Akt and human disease
- 2012 - 2014 HDAC1結合蛋白による抗がん剤耐性機構に基づく新たな分子標的治療の開発研究
- 2011 - 2014 生後の血管新生、神経新生を制御する分子メカニズムと病態形成
- 2007 - 2011 Role of the new Akt substrate Girdin and its family proteins in pathogenesis
- 2005 - 2010 受容体型チロシンキナーゼによる増殖シグナルの制御機構
- 2007 - 2008 CD109 expression in the head and neck squamous cell carcinoma
- 2007 - GPIアンカー型膜蛋白CD109を標的とした扁平上皮癌に対する新規診断法の開発
- 2005 - 2006 新規Akt基質タンパク質の細胞運動・形態形成における機能の解明
- 2003 - 2006 In vivo role of the GDNF/RET signaling pathway in morphogenesis and pathogenesis
- 2004 - 2005 腎臓発生に重要なRetシグナル伝達下流で活性化される新規Akt基質蛋白の機能解析
- 2004 - 2005 腎臓の発生と再生における新規遺伝子GZF1の役割に関する研究
- 2004 - 2005 GDNF-inducible zinc finger protein 1 regulates organogenesis as a sequence specific transcriptional repressor
- 2004 - 2004 新規Akt結合蛋白の機能解析
- 2002 - 2004 Adenoviral-mediated Delivery of anti RET Hammerhead Ribozymes Inhibits Thyroid Medullary Carcinoma Cell Proliferation.
- 2003 - 2003 新規Akt結合蛋白の機能解析
- 1998 - 2002 Molecular Medicine of Neurodegenerative Disease and Malignant Tumor
- 2000 - 2001 Glial cell line-derived neurtftrophic factor (GDNF) inducible genes and neuronal differentiation
- 1998 - 2000 Mechanism of the Expression of Various Phenotypes in Multiple Endocrine Neoplasia Type 2
- 1999 - 1999 がん進展に関わる分子の診断・治療への応用
- 1999 - 1999 ヨーロッパなどががん研究先進国との研究交流
- 1997 - 1999 Analysis of molecular mechanisms of cancer metastasis using transgenic mice
- 1998 - 1998 家族性筋萎縮性側索硬化症型変異を持つCu/ZnSODのGDNF/Ret系への影響
- 1998 - 1998 Ret蛋白の変異によって生じる多様な臨床病態の解析
- 1998 - 1998 フラット・リバージョン誘導遺伝子RECKによるがん転移抑制機構
- 1997 - 1997 GDNF-Ret系を介した神経分化機構の解析
- 1997 - 1997 Ret蛋白の変異によって生じる多様な臨床病態の解析
- 1996 - 1997 Functional Analysis of ret Oncogene with Multiple Endocrine Neoplasia Type 2
- 1996 - 1996 機能性腸閉塞症の原因と病態に関する研究
- 1996 - 1996 retプロトオンコジーンのリガンドの同定と機能解析
- 1996 - 1996 Ret蛋白の変異によって生じる多様な臨床病態の解析
- 1995 - 1995 Ret蛋白の変異によって生じる多様な臨床病態の解析
- 1994 - 1995 Role of the ret proto-oncogene in the development of the enteric nervous system
- 1992 - 1993 cDNA cloning of novel tyrosine kinases expressed in neuronal cells
- 1991 - 1993 細胞癌における蛋白質リン酸化
- 1992 - 1992 retがん遺伝子導入トランスジェニックマウスを用いた細胞がん化と転移に関する研究
- 1991 - 1991 甲状腺癌におけるret癌遺伝子
- 1990 - 1991 Melanovytic tumor development in transgenic mice carrying the ret oncogene
- 1990 - 1990 レトロウイルスを利用した癌関連遺伝子の探索とその発現・機能の解析
- 1987 - 1988 The immunohistological study of the ret oncogene product by a monoclonal antibody raised against a synthetic peptide
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Papers (219):
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Hyogo Naoi, Yuzo Suzuki, Asuka Miyagi, Ryo Horiguchi, Yuya Aono, Yusuke Inoue, Hideki Yasui, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, et al. CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling. Journal of immunology (Baltimore, Md. : 1950). 2024. 212. 7. 1221-1231
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Ryota Ando, Yukihiro Shiraki, Yuki Miyai, Hiroki Shimizu, Kazuhiro Furuhashi, Shun Minatoguchi, Katsuhiro Kato, Akira Kato, Tadashi Iida, Yasuyuki Mizutani, et al. Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas. The Journal of pathology. 2023
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Yuya Aono, Yuzo Suzuki, Ryo Horiguchi, Yusuke Inoue, Masato Karayama, Hironao Hozumi, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, et al. CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation. American journal of respiratory cell and molecular biology. 2022. 68. 2. 201-212
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迫田 朋佳, 江崎 寛季, 安藤 良太, 宮井 雄基, 飯田 忠, 松山 誠, 白木 之浩, 三井 伸二, 西田 佳弘, 高橋 雅英, et al. 骨肉腫におけるMeflin陽性細胞を標的とした抗体薬物複合体の研究開発(An Effective Therapy that Antibody-Drug Conjugates Targeting Meflin(+) Cells for Osteosarcoma). 日本癌学会総会記事. 2022. 81回. E-2021
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Yuki Miyai, Daisuke Sugiyama, Tetsunari Hase, Naoya Asai, Tetsuro Taki, Kazuki Nishida, Takayuki Fukui, Toyofumi Fengshi Chen-Yoshikawa, Hiroki Kobayashi, Shinji Mii, et al. Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade. Life Science Alliance. 2022. 5. 6. e202101230-e202101230
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MISC (199):
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Tetsuro Taki, Shinji Mii, Yukihiro Shiraki, Atsushi Enomoto, Masahide Takahashi. Dissection of the function of CD109 in lung adenocarcinoma. CANCER SCIENCE. 2018. 109. 1407-1407
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Yoshinori Yasuda, Shintaro Iwama, Atsushi Kiyota, Hisakazu Izumida, Kohtaro Nakashima, Naoko Iwata, Yoshihiro Ito, Yoshiaki Morishita, Motomitsu Goto, Hidetaka Suga, et al. Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis. Journal of Pathology. 2018. 244. 4. 469-478
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Kaori Ushida, Naoya Asai, Kozo Uchiyama, Atsushi Enomoto, Masahide Takahashi. Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note. Pathology International. 2018. 68. 4. 241-245
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Tomoki Maegawa, Yuki Miyasaka, Misato Kobayashi, Naru Babaya, Hiroshi Ikegami, Fumihiko Horio, Masahide Takahashi, Tamio Ohno. Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11. Mammalian Genome. 2018. 29. 3-4. 273-280
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Liang Weng, Yi-Peng Han, Atsushi Enomoto, Yasuyuki Kitaura, Shushi Nagamori, Yoshikatsu Kanai, Naoya Asai, Jian An, Maki Takagishi, Masato Asai, et al. Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex. PLoS biology. 2018. 16. 3. e2005090
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Books (32):
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サイトカイン・増殖因子キーワード事典;GDNFファミリー、RET,、GDNFファミリー受容体複合体
羊土社 2015
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Protein Modifications in Pathogenic Dysregulation of Signaling; Critical Roles of the AKT Substrate Girdin in Disease Initiation and Progression
2015
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Robbins Basic Pathology 9th Edition
2014
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がんー疾患モデルの作製と利用 RET
株式会社 エル・アイ・シー 2012
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Aktシグナルによるがん細胞の運動制御ーアイソフォームに依存する分子機構
実験医学増刊(羊土社) 2012
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Lectures and oral presentations (5):
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Roles of the Akt substrate Girdin in cancer progression and angiogenesis
(International Symposium on Nanomedicine 2014)
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Roles of the Akt substrate Girdin in cell motility
(1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling 2013)
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Roles of the Akt substrate Girdin in cancer progression, angiogenesis and neurogenesis
(Global Center of Excellence (COE) Program, The 4th International Symposium 2012)
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Roles of the Akt substrate Girdin in cancer progression and angiogenesis
(Global center of excellence (COE) Program, the 3rd International Symposium 2011)
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Roles of RET tyrosine kinase and Akt signaling in human disease
(Wihship Cancer Institute, Elkin Lecture Series 2011)
Education (2):
- - 1983 Nagoya University Graduate School, Division of Medicine
- - 1979 Nagoya University Faculty of Medicine
Professional career (1):
- Medical Doctor (Nagoya University)
Work history (5):
- 2020/04 - 現在 Fujita Health University International Center for Cell and Gene Therapy Director, Designated Professor
- 2020/04 - 現在 Fujita Health University
- 2017/04 - 2020/03 Nagoya University Trustee / Vice President Professor, Graduate School of Medicine
- 2013/04 - 2020/03 Nagoya University Graduate School of Medicine Center for Neural Disease and Cancer Division Professor
- 2004/10/01 - 2013/03/31 Nagoya University Graduate School of Medicine Center for Neural Disease and Cancer Professor
Awards (8):
- 2020/11 - Japanese Goverment Medal with Purple Ribbon
- 2020/02 - Princess Takamatsu Cancer Research Fund Princess Takamatsu Cancer Research Fund Prize
- 2019/11 - Japan Medical Association Medical Award of The Japan Medical Association
- 2010/05 - Chunichi Shimbun Co. Ltd. Chunichi Cultural Award
- 2006/03 - Yomiuri Newspaper Co. The Yomiuri-Tokai Medical Award
- 2001/04 - The Japan Society of Pathology The Japan Pathology Award
- 1993/11 - The Japan Society of Pathology ー
- 1990/10 - Japanese Cancer Association The Young Investigator Award of the Japanese Cancer Association
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Association Membership(s) (3):
日本分子生物学会
, 日本病理学会
, 日本癌学会
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