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J-GLOBAL ID：200901036346887896 Update date: Mar. 04, 2025

Kawada Norifumi

カワダノリフミ | Kawada Norifumi

Affiliation and department：
Job title： Professor

Research field (2)： Gastroenterology , Gastroenterology

Research keywords (1)： Gastroenterology

Research theme for competitive and other funds (44)：

2022 - 2025 肝細胞のがん化における細胞間相互作用を介した星細胞の役割
2021 - 2024 B型肝炎の治療抵抗性および病態進展における免疫チェックポイント分子の関与
2021 - 2024 Cytoglobin (CYGB)-overexpression and targeted demethylation of CYGB promoter impair liver and pancreatic tumor growth
2020 - 2023 Basic study for developing NASH therapeutic drugs by using a small molecule derived from the cellular slime mold serving as a lead compound
2019 - 2023 地元大阪の印刷所労働者胆管がん組織を使ったがん遺伝子の探索:創薬基盤の構築

2019 - 2022 Are activated stellate cells producing Cytoglobin directly involved in hepatocarcinogenesis?

2019 - 2021 リコンビナントCytoglobinを用いた脱肝線維化治療薬開発に関する研究

2016 - 2019 Explore of new target factor which related with suppression of liver fibrosis, based on functional analysis of bile acids.

2016 - 2019 MicroRNA as a biomarker for prediction of HCC development after achieving an SVR

2016 - 2019 Development of anti-fibrotic therapy for liver disease by establishing technologies that regulate cytoglobin expression in hepatic stellate cells

2015 - 2019 Genetic risk verification of juvenile-onset cholangiocarcinoma

2014 - 2018 Multiple comparative analysis of FXR-inhibitory effect on liver carcinogenesis

2014 - 2017 Study on miRNA expression and single nucleotide polymorphisms in hepatocellular carcinoma after HCV eradication

2013 - 2017 Mechanism of formation of hepatic steatosis in Non-alcoholic fatty liver disease (NAFLD)

2013 - 2016 MicroRNA as a liver fibrosis marker in chronic hepatitis B

2013 - 2016 Involvement of Cytoglobin expressed in hepatic stellate cells in the development of cancer derived from inflamed liver.

2011 - 2013 癌微小環境形成におけるサイトグロビン陽性あるいは陰性筋線維芽細胞の役割

2011 - 2013 The ability of tisuue repair and regeneration in steatohepatitic liver

2010 - 2011 Involvement of cytoglobin-expressing mesenchymal cells in cancer development

2009 - 2011 Intrahepatic microRNA expression and response to peginterferon-α and ribavirin therapy in patients with chronic hepatitis C

2009 - 2011 Analyses of the development of liver cancer and cirrhosis by using cytoglobin-deficient mice

2009 - 2009 慢性肝障害バイオマーカーとしてのサイトグロビンの有用性の検討

2006 - 2007 変性赤血球による非アルコール性脂肪性肝炎病態の修飾

2006 - 2007 The role of intermediateted filament proteins in hepatic stellate cells in the development of liver fibrosis and hepatocellular carcinoma

2006 - 2006 ShRNAライブラリーを用いた肝線維化,癌化関連因子の網羅的解析と治療への応用

2005 - 2006 Molecular Mechanism for Anencephaly

2004 - 2005 Functional analysis of cytoglobin that is expressed and induced in liver cirrhosis

2004 - 2005 Targeted and regulable expression of transgenes in hepatic stellate cells using an adenoviral Cre-loxP system

2004 - 2005 Improvement of perioperative and postoperative management after hepatic resection for HCC by the regulation of hepatic stellate cells.

2003 - 2003 ストレス応答蛋白チオレドキシンによる新しい術後肝障害防止対策

2002 - 2003 Functional analysis of stap, a novel gene expressed in hepatic stellate cells and fibrotic liver tissue and its significance in clinicopathophysiology

2002 - 2003 The signal pthway and the role of the discoidin domain receptor 2 (DDR2) which is stimulated by type I collagen

2002 - 2003 Development of perioperative management for hepatic resection based on the stellate cell function

2001 - 2002 Regulation of hepatic micro circulation by hepatic stellate cell-Application of NAC to liver failure

2001 - 2001 肝細胞・肝星細胞の供培養による細胞増殖相互作用

2000 - 2001 Strategy for Liver Failure by Regulating Hepatic Microcirculation through Hepatic Stellate Cell Activatity

2000 - 2000 N-acetylcysteineによる星細胞活性化の制御

1999 - 2000 Pathophysiological Analysis of Prion Protein Expression in the Liver

1999 - 2000 Aspect of Strategy for Liver Failure by Regelating Hepatic Stellate Cell Activation

1998 - 1999 New Strategy for Liver Failure by Regulating Hepatic Extracellular Matrix

1997 - 1998 肝星細胞活性化の分子解析とそれを利用した肝線維化抑制法の開発

1996 - 1996 肝類洞細胞に発現する特異蛋白のcDNAクローニングとその機能解析

肝細胞壊死と肝線維化の分子機構に関する研究

Study on molecular mechanism of hepatocyte death and liver fibrosis

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Papers (480)：

Hideto Yuasa, Tsutomu Matsubara, Hayato Urushima, Atsuko Daikoku, Hiroko Ikenaga, Chiho Kadono, Masahiko Kinoshita, Kenjiro Kimura, Takeaki Ishizawa, Keisuke Ohta, et al. Cdc42 is crucial for the early regulation of hepatic stellate cell activation. American Journal of Physiology-Cell Physiology. 2025
Yuki Tahata, Hayato Hikita, Satoshi Mochida, Nobuyuki Enomoto, Norifumi Kawada, Akio Ido, Daiki Miki, Masayuki Kurosaki, Hitoshi Yoshiji, Ryotaro Sakamori, et al. Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy. Hepatology research : the official journal of the Japan Society of Hepatology. 2024
武藤芳美, 河田則文, 大谷直子. 脂肪性肝疾患を探究する日本食摂取による腸内細菌叢変化とMASLDの病態進展への影響. 肝臓. 2024. 65. Suppl.3. A767-A767
神谷知憲, 越前佳奈恵, 河田則文, 大谷直子, 大谷直子. 脂肪性肝炎関連肝がんにおける組織常在型メモリーT細胞の活性化メカニズムと治療への応用(Elucidating the activation mechanism of tissue resident memory T cells to MASLD-HCC and its therapeutic application). 日本癌学会総会記事. 2024. 83回. P-1169
Hideki Fujii, Yoshihiro Kamada, Akihiro Tokushige, Toshio Watanabe, Norifumi Kawada. Is liver fibrosis more advanced in MetALD than in MASLD?. Journal of hepatology. 2024

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MISC (218)：

Naoko Ohtani, Tomonori Kamiya, Norifumi Kawada. Recent updates on the role of the gut-liver axis in the pathogenesis of NAFLD/NASH, HCC, and beyond. Hepatology Communications. 2023. 7. 9
松原三佐子, 平敏夫, 城戸康年, 中釜悠, 河田則文, 吉里勝利. 新興感染症:新型コロナウイルスに即応する生化学〜診断・治療・疫学への越境唾液内生理活性物質の抗ウイルス効果. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [1S10a-05]
田守昭博, 木村公則, 木岡清英, 榎本平之, 小田桐直志, 小塚立蔵, 打田佐和子, 榎本大, 河田則文, 溝上雅史. HBV再活性化対策のために投与された核酸アナログの中止基準の検討. 肝臓. 2021. 62. Suppl.1. A397-A397
Truong Huu Hoang, 松原三佐子, 河田則文. 肝類洞内皮細胞の細胞内ギャップ形成はがん細胞の肝転移能力を促進する(Intracellular gap formation of the liver sinusoidal endothelial cells facilitates the liver metastasis ability of cancer cell). 日本消化器病学会雑誌. 2021. 118. 臨増総会. A390-A390
Xiaolong Qi, Yanna Liu, Jitao Wang, Jonathan A. Fallowfield, Jianwen Wang, Xinyu Li, Jindong Shi, Hongqiu Pan, Shengqiang Zou, Hongguang Zhang, et al. Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: A multicentre cohort study. Gut. 2021. 70. 2. 433-436

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Patents (23)：

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Lectures and oral presentations (22)：

Interaction between CD4+T cells and tumor cells in hepatocellular carcinoma microenvironment.
(2021)
Novel Anti-Fibrotic Function of Neuroglobin in vitro and in vivo
(2021)
Cytoglobin欠損マウスの肝星細胞に由来する一酸化窒素は肝細胞のミトコンドリア機能障害を引き起こす
(第35回肝類洞壁細胞研究会 2021)
6. Anti-fibrotic Capacity of Extracellular Globins via Scavenging ROS and Promoting MMP-1 Secretion.
(American Association for the Study of Liver Diseases (AASLD) 2021)
Investigation of;CYGB;promoter methylation in hepatocellular carcinoma;
(American Association for the Study of Liver Diseases (AASLD) 2021)

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Education (1)：

- 1991 Osaka City University Graduate School, Division of Medicine

Professional career (2)：

博士(医学)
Doctor of Medicine

Work history (2)：

2022/04 - 現在 Osaka Metropolitan University Graduate School of Medcine Department of Clinical Medical Science Professor & Chairman
1994/10/01 - 現在 Osaka City University Graduate School of Medicine Clinical Medicine Course Professor

Awards (5)：

2012/11 - 大阪市立大学学友会賞
2012 - バイオビジネスアワードJAPANバイオ先端知賞
2002 - Karl von Kuppfer Prize
1994 - 日本肝臓学会研究奨励賞
1991 - 大阪市医学会市長賞

Association Membership(s) (9)：

EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER , 米国消化器病学会 , 米国肝臓学会 , 日本生化学会 , 日本内科学会 , 日本肝臓学会 , 日本消化器類学会 , 日本門脈圧亢進症学会 , 日本消化器病学会

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