Rchr
J-GLOBAL ID：200901039325790433   Update date: Nov. 11, 2024

Futaki Shiroh

フタキ シロウ | Futaki Shiroh
Affiliation and department：
Kyoto University Institute for Chemical Research, Division of Biochemistry, Biofunctional Design Chemistry

About Kyoto University Institute for Chemical Research, Division of Biochemistry, Biofunctional Design Chemistry


Homepage URL  (1)： http://www.scl.kyoto-u.ac.jp/~bfdc/index.html
Research field  (3)： Pharmaceuticals - chemistry and drug development ,  Molecular biochemistry ,  Pharmaceuticals - health and biochemistry
Research keywords  (6)： ペプチド工学 ,  細胞機能化学 ,  ペプチド化学 ,  Peptide Engineering ,  Cell Functional Chemistry ,  Peptide Chemistry
Research theme for competitive and other funds  (45)：
  • 2024 - 2029 Understanding the molecular and cellular basis and controlling cellular phenomena: A New Concept for Intracellular Delivery of Antibodies
  • 2021 - 2024 細胞内抗原を標的としたin vivo抗体送達のための分子設計
  • 2018 - 2023 Functional regulation of ubiquitin chains using chemo-technologies
  • 2020 - 2022 生体膜の曲率・脂質パッキング状態変化を誘起する機能性ペプチドと展開
  • 2018 - 2021 New approaches for intracellular delivery of bioactive proteins
Show all
Papers (439)：
  • Junya Michibata, Yoshimasa Kawaguchi, Hisaaki Hirose, Akiko Eguchi, Sayaka Deguchi, Kazuo Takayama, Wei Xu, Takuro Niidome, Yoshihiro Sasaki, Kazunari Akiyoshi, et al. Polysaccharide-Based Coacervate Microgel Bearing Cationic Peptides That Achieve Dynamic Cell-Membrane Structure Alteration and Facile Cytosolic Infusion of IgGs. Bioconjugate chemistry. 2024
  • Yoshinobu Takakura, Rikinari Hanayama, Kazunari Akiyoshi, Shiroh Futaki, Kyoko Hida, Takanori Ichiki, Akiko Ishii-Watabe, Masahiko Kuroda, Kazushige Maki, Yasuo Miura, et al. Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles. Pharmaceutical research. 2024. 41. 8. 1573-1594
  • Yoshimasa Kawaguchi, Sakahiro Terada, Shiroh Futaki. An approach for the intracellular delivery of IgG via enzymatic ligation with a cell-permeable attenuated cationic amphiphilic lytic peptide. Bioorganic & medicinal chemistry. 2024. 111. 117835-117835
  • Yoshimasa Kawaguchi, Shiroh Futaki. Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells. Current opinion in chemical biology. 2024. 81. 102482-102482
  • Shunsuke Yoshie, Masashi Kuriyama, Masashi Maekawa, Wei Xu, Takuro Niidome, Shiroh Futaki, Hisaaki Hirose. ATP2B4 is an essential gene for epidermal growth factor-induced macropinocytosis in A431 cells. Genes to cells : devoted to molecular & cellular mechanisms. 2024
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MISC (269)：
  • 栗山 理志, 広瀬 久昭, 川口 祥正, 二木 史朗. ペプチドによる細胞内送達の効率と遺伝子発現の相関解析. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1T13a-448)]
  • 中川優奈, 川口祥正, 橋口隆生, 二木史朗. SARS-CoV-2S protein搭載による細胞外小胞の膜融合促進. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2023. 44th
  • 栗山理志, 広瀬久昭, 川口祥正, 二木史朗. The mechanism of action of intracellular delivery peptide L17E. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 川口 祥正, 伊勢 祥子, 二木 史朗. Ni(II)/ジピコリルアミン修飾によるオクタアルギニンペプチドの細胞膜透過促進. 日本薬学会年会要旨集. 2022. 142年会. 27N-pm22
  • 岡野 秀亮, 川口 祥正, 河野 健一, 二木 史朗. ペプチド・タンパク質医薬のサイトゾル送達量の定量的評価系構築. 日本薬学会年会要旨集. 2022. 142年会. 27N-pm18S
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Books (27)：
  • ペプチドの細胞膜との相互作用と細胞内送達
    化学同人 2021
  • Protein Delivery to Cytosol by Cell-Penetrating Peptide Bearing Tandem Repeat Penetration-Accelerating Sequence
    Springer 2021
  • ペプチドを用いた細胞内デリバリー
    シーエムシー出版 2019
  • Photoaffinity Labeling Methods to Explore Internalization Mechanisms of Arginine-Rich Cell-Penetrating Peptides
    Springer Japan 2017
  • 細胞透過性
    シーエムシー出版 2017
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Lectures and oral presentations  (266)：
  • Peptides that affect membrane structure and permeability
    (The 59th Japanese Peptide Symposium 2022)
  • 抗体・機能性タンパク質の細胞内送達に向けて
    (第72回日本薬学会関西支部大会 2022)
  • 抗体・機能性タンパク質の細胞内送達に向けて
    (慶應義塾大学大学院薬学研究科特別講義 2022)
  • 膜と相互作用する機能性ペプチド
    (第30回ケムステVシンポ「世界に羽ばたく日本の化学研究」 2022)
  • Attenuated cationic lytic peptides for intracellular delivery
    (36th European and 12th International Peptide Symposium 2022)
ｍore...
Professional career (1)：
  • Doctor of Pharmaceutical Science
Awards (4)：
  • 2022/10 - The Japanese Peptide Society The Akabori Memorial Award 2022
  • 2020/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award
  • 1998 - 日本薬学会奨励賞
  • 1997 - 日本ペプチド学会奨励賞
Association Membership(s) (5)：
The Pharmaceutical Society of Japan ,  日本生化学会 ,  アメリカ化学会(American Chemical Society) ,  日本ペプチド学会 ,  日本化学会
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