Rchr
J-GLOBAL ID:200901039459246357
Update date: Feb. 14, 2024 Miura Tomoyuki
ミウラ トモユキ | Miura Tomoyuki
Affiliation and department: Job title:
Associate Professor,Associate Professor
Other affiliations (1): Homepage URL (1): https://www2.infront.kyoto-u.ac.jp/primatemodelHP/ Research field (2):
Virology
, Veterinary medicine
Research keywords (8):
分子進化
, エイズ
, 動物モデル
, レトロウイルス
, molecular evolution
, AIDS
, Animal model
, retrovirus
Research theme for competitive and other funds (43): - 2019 - 2022 Study of virus reservoir injury treatment on primate AIDS model
- 2018 - 2021 Evaluation of protective immune responses by recombinant BCG/vaccinia prime-boost AIDS vaccine in macaque model of SIV infection
- 2016 - 2018 Development of a mice having simian immune systems-Establishment of a new animal model for analysis of pathogenesis in viral infection
- 2014 - 2017 HIV-1感染症の機能的治癒におけるウイルスリザーバーサイズの意義
- 2011 - 2012 Establishment of a simple, easy and useful new recombinant virus manufacture system using a homologous recombination phenomenon
- 2009 - 2011 Basic study on viral genome related to pathogenesis of SHIV infection in non-human primate AIDS model
- 2006 - 2010 HIV-1複製を阻害する低分子化合物の開発とそれをプローブに用いた分子イメージング技術によるウイルスの動態解析
- 2006 - 2010 Study on small molecule for anti-HIV-1 Vpr and its application for molecular imaging
- 2006 - 2008 Study for molecular basis of AIDS pathogenesis on non-human primate model
- 2006 - 2008 Elucidation of the mechanism that HIV got over a species barrier from monkey to human using simian/human recombinant immunodeficiency virus
- 2006 - 2008 弱毒SHIVによる感染防御効果成立機序の解析とワクチンへの応用
- 2006 - 2008 Empirical study on the formation of AIDS pathogenesis by primate model
- 2006 - 2008 霊長類モデルを用いたエイズ腸管病態形成機構の解明と治療への応用
- 2006 - 2008 Study on host barrier using SHIV
- 2006 - 2008 Study on attenuated-SHIV vaccine model
- 2006 - 2008 Genetic bases of AIDS pathogenesis on nonhuman primate models
- 2006 - 2008 Study on AIDS enteropathy using nonhuman primate model
- 2005 - 2008 Molecular epidemiology of HIV in central Africa - Searching for the origin of AIDS virus and its future
- 2001 - 2004 Comparison between histopathological changes and infectious virus productive organs of acute pathogenic and non-pathogenic SHIV infected monkeys-The detection of HIV-1 productive organs.
- 2002 - 2003 サル感染モデルによるエイズ病原性の分子基盤
- 2001 - 2001 遺伝子改変SHIVを用いたHIV-1の病原性と宿主免疫応答の解析
- 1998 - 1999 Origin and molecular evolution of primate lentiviruses-Genetic analysis of HIV/HTLV in Africa
- 1996 - 1997 Isolation and analyzes of HIV・HTLV related viruses from humans and monkeys in Africa
- 1995 - 1997 Pathology and Molecular Evolution of HTLV in Asia
- 1994 - 1996 霊長類レトロウイルスの分子進化
- 1995 - 1995 霊長類レトロウイルスの分子進化
- 1995 - 1995 アル白血病ウイルスの遺伝子と病態
- 1993 - 1995 Isolation of AIDS-related viruses from African Primates
- 1994 - 1994 Viroepidemiological study of HTLV-I/II in Jamaica and Colombia
- 1994 - 1994 Epidemiology and pathology of human retrovirus infection
- 1994 - 1994 サル白血病ウイルスの遺伝子と病態
- 1992 - 1993 Viroepidemiological study on HTLV-I/II in Jamaica and Colombia
- 1992 - 1993 Epidemiology and pathology of human retro virus infection.
- 1992 - 1992 サル免疫不全ウイルスmRNAに特異的に存在するループ構造の解析
- 1991 - 1991 Seroepidemiology of ATL/AIDS-related viruses and comparative virology and pathology
- 1991 - 1991 感染症DNAク-ロンを用いたHIU/SIUの病原性と変異の解析
- 1991 - 1991 PCR法を用いた新しいエイズ関連ウイルスの検出とその系統発生学的研究
- 1991 - 1991 ネコ免疫不全ウイルスの遺伝的背景
- 1990 - 1990 感染性DNAクロ-ンを用いたHIV/SIVの病原性と変異の解析
- 1990 - 1990 PCR法を用いた新しいエイズ関連ウイルスの検出とその系統発生学的研究
- 1989 - 1989 感染性DNAクローンを用いたHIV/SIVの病原性と変異の解析
- 1989 - 1989 HIVのR遺伝子(vpr)の同定とその機能解析
- 1988 - 1988 サル免疫不全ウイルス(SIV)の遺伝子構造と機能に関する分子生物学的研究
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Papers (189): -
Hirotaka Ode, Akatsuki Saito, Ayaka Washizaki, Yohei Seki, Takeshi Yoshida, Shigeyoshi Harada, Hiroshi Ishii, Tatsuo Shioda, Yasuhiro Yasutomi, Tetsuro Matano, et al. Development of a novel Macaque-Tropic HIV-1 adapted to cynomolgus macaques. Journal of General Virology. 2022. 103. 10
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Hiroshi Ishii, Kazutaka Terahara, Takushi Nomura, Midori Okazaki, Hiroyuki Yamamoto, Tsugumine Shu, Hiromi Sakawaki, Tomoyuki Miura, David I Watkins, Tetsuro Matano. Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8+ T cells but not CD4+ T cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2022. 50. 5. 1-10
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Yalcin Pisil, Zafer Yazici, Hisatoshi Shida, Tomoyuki Miura. Is SARS-CoV-2 Neutralized More Effectively by IgM and IgA than IgG Having the Same Fab Region?. Pathogens (Basel, Switzerland). 2021. 10. 6. 751-751
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Yoshihiro Iwamoto, Yohei Seki, Kahoru Taya, Masahiro Tanaka, Shoichi Iriguchi, Yasuyuki Miyake, Emi E Nakayama, Tomoyuki Miura, Tatsuo Shioda, Hirofumi Akari, et al. Generation of macrophages with altered viral sensitivity from genome-edited rhesus macaque iPSCs to model human disease. Molecular therapy. Methods & clinical development. 2021. 21. 262-273
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Takuya Kobayakawa, Kohei Tsuji, Kiju Konno, Ai Himeno, Ami Masuda, Tingting Yang, Kohei Takahashi, Yusuke Ishida, Nami Ohashi, Takeo Kuwata, et al. Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors. Journal of medicinal chemistry. 2021. 64. 3. 1481-1496
more... MISC (181): -
Yohei Seki, Akatsuki Saito, Shigeyoshi Harada, Ayaka Washizaki, Megumi Murata, Yuta Hikichi, Kazuhisa Yoshimura, Hiroshi Ishii, Yorifumi Satou, Islam Mohammad Saiful, et al. Cooperative cellular and humoral immunity may contribute to the efficient control of HIV-1 replication in macaques. 36th Annual Symposium Nonhuman Primate Models for AIDS. 2018
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Shigeyoshi Harada, Yuta Hikichi, Yohei Seki, Yasumasa Iwatani, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano, Hirofumi Akari, Kazuhisa Yoshimura. Molecular characterization of the env gene during transmission of macaque-tropic human immunodeficiency virus type 1 (HIV-1mt). 36th Annual Symposium Nonhuman Primate Models for AIDS. 2018
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Shigeyoshi Harada, Yuta Hikichi, Yohei Seki, Akatsuki Saito, Takeshi Yoshida, Hirotaka Ode, Yasumasa Iwatani, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano, et al. Bi-functional entry inhibitors sensitize macaque-tropic human immunodeficiency virus type 1 (HIV-1mt) to antibodies generated in HIV-1mt-infected macaques. JOURNAL OF MEDICAL PRIMATOLOGY. 2018. 47. 5. 333-333
- 野村拓志, 野村拓志, 石井洋, 関紗由里, 山本浩之, 寺原和孝, 三浦智行, 俣野哲朗, 俣野哲朗. SIV複製制御個体におけるSIV野生型/変異型エピトープ特異的CTL誘導動態の解析. 日本エイズ学会誌. 2017. 19. 4. 415
- 関洋平, 齊藤暁, 佐藤賢文, 原田恵嘉, 吉村和久, 大出裕高, 岩谷靖雅, 石井洋, SAIFULISLAM M, 芳田剛, et al. カニクイザルにおけるHIV-1mt長期潜伏感染の解析. 日本エイズ学会誌. 2017. 19. 4. 417-417
more... Patents (1): Books (3): - 「成人T 細胞白血病ウイルスの系統分析と人類の移動」
Science of Humanity ,42:50-59 頁 2003
- Surveys of SIV among nonhuman primate populations.
Current Topics in Microbiology and Immunology, Springer-Verlag,188/,1-20 1994
- ヒトレトロウイルス
日本生化学会編,新生化学実験講座第16巻分子進化実験法,39-53 1992
Education (4): - - 1988 The University of Tokyo
- - 1988 The University of Tokyo Graduate School, Division of Agricultural Science Veterinary Medicine
- - 1983 The University of Tokyo
- - 1983 The University of Tokyo Faculty of Agriculture Veterinary Medicine
Professional career (1): - Doctor of Agriculture (The University of Tokyo)
Work history (10): - 2016/10 - 現在 ウイルス・再生医科学研究所 准教授
- 2002/04 - 2016/09 Kyoto University Institute for Virus Research
- 1998/04 - 2002/03 Kyoto University Institute for Virus Research
- 1988/08 - 1998/03 Kyoto University Institute for Virus Research
- 1988 - 1998 Inst. for Virus Research, Kyoto Univ. , Instructor
- - 1998 1988 Aug.-1998 Apr. Instructor,Inst.for Virus Res.
- 1998 - Apr.-present Associate Professor,Inst.for Virus Res.
- 1988/04 - 1988/07 日本学術振興会特別研究員
- 1988 - Apr.-Aug. JSPS research fellow
- Kyoto Univ.
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Association Membership(s) (3):
日本獣医学会
, 日本エイズ学会
, 日本ウイルス学会
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