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J-GLOBAL ID:200901040711421980   Update date: Dec. 16, 2024

Toshihiko Torigoe

トリゴエ トシヒコ | Toshihiko Torigoe
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Affiliation and department:
Job title: Professor
Homepage URL  (1): http://web.sapmed.ac.jp/patho1/research/report02.html
Research field  (5): Experimental pathology ,  Cell biology ,  Human pathology ,  Tumor diagnostics and therapeutics ,  Tumor biology
Research keywords  (5): Autoimmunity, Autoantibody, Inflammation ,  Cancer Stem Cell, Oncogene, Tumor Suppressor ,  Immunopathology, Human Pathology ,  Cellular Stress Response, Heat Shock Protein, Molecular Chaperone ,  Cancer Immunity, Immunotherapy, Vaccine, T-cell Therapy
Research theme for competitive and other funds  (35):
  • 2023 - 2026 A study of computer aided diagnosis system of cervical cytology using deep learning.
  • 2021 - 2025 Comprehensive analysis of T-cell receptor ligand by using pHLA multimer library
  • 2020 - 2023 development of combined immunotherapy targeting ero1 in triple negative breast cancer
  • 2020 - 2023 乳癌の転移巣を伴うリンパ節内のT-cellにおける免疫応答
  • 2018 - 2021 Identification of mutation-derived spliced peptides
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Papers (413):
  • Kanta Hori, Shuhei Yamada, Kenji Murata, Haruka Miyata, Yuka Mizue, Aiko Murai, Tomoyuki Minowa, Kenta Sasaki, Naoki Shijubou, Terufumi Kubo, et al. Establishment of potent TCR-T cells specific for cisplatin-resistance related tumor-associated antigen, CLSPN using codon-optimization. Human vaccines & immunotherapeutics. 2024. 20. 1. 2414542-2414542
  • Minami Fusagawa, Serina Tokita, Kenji Murata, Tasuku Mariya, Mina Umemoto, Shintaro Sugita, Kazuhiko Matsuo, Yoshihiko Hirohashi, Tsuyoshi Saito, Takayuki Kanaseki, et al. Identification and phenotypic characterization of neoantigen-specific cytotoxic CD4+ T cells in endometrial cancer. Cancer Immunology Research. 2024
  • Tomoyuki Minowa, Kenji Murata, Yuka Mizue, Aiko Murai, Munehide Nakatsugawa, Kenta Sasaki, Serina Tokita, Terufumi Kubo, Takayuki Kanaseki, Tomohide Tsukahara, et al. Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment. Science translational medicine. 2024. 16. 776. eadk8832
  • Serina Tokita, Takayuki Kanaseki, Toshihiko Torigoe. Neoantigen prioritization based on antigen processing and presentation. Frontiers in Immunology. 2024. 15
  • Serina Tokita, Minami Fusagawa, Satoru Matsumoto, Tasuku Mariya, Mina Umemoto, Yoshihiko Hirohashi, Fumitake Hata, Tsuyoshi Saito, Takayuki Kanaseki, Toshihiko Torigoe. Identification of immunogenic HLA class I and II neoantigens using surrogate immunopeptidomes. Science advances. 2024. 10. 38. eado6491
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MISC (286):
  • 染谷正則, 長谷川智一, 北川未央, 土屋高旭, 眞船翔, 後町俊夫, 池内佑太郎, 金関貴幸, 鳥越俊彦, 坂田耕一. 化学放射線療法+免疫療法を行った3期切除不能非小細胞肺癌における,末梢血リンパ細胞のTCRレパトア解析. 日本免疫治療学会学術集会プログラム・抄録集. 2023. 20th
  • 鳥越俊彦. Advances of cancer immunotherapy: pan-cancer rationale and perspectives. 札幌冬季がんセミナー. 2023. 37th
  • 和田朝香, 九冨五郎, 廣橋良彦, 田村保明, 島宏彰, 空閑陽子, 鳥越俊彦, 竹政伊知朗. 上皮間葉系細胞転換(EMT)促進因子を標的とする新規乳癌治療. 日本外科学会定期学術集会(Web). 2023. 123rd
  • 安部紘生, 梶原由規, 望月早月, 神藤英二, 岡本耕一, 阿尾理一, 永田健, 廣橋良彦, 鳥越俊彦, 岸庸二, et al. 大腸癌の癌関連線維芽細胞とがん幹細胞性の関連におけるPeriostinの役割-抗Periostin抗体OC-20を用いたDesmoplastic Reaction分類別の検討. 日本外科学会定期学術集会(Web). 2023. 123rd
  • 小林進, 金関貴幸, 時田芹奈, 鳥越俊彦, 柿崎秀宏. Human endogenous retrovirus (HERV) antigens are presented by HLA class I of renal cell carcinoma. 日本泌尿器科学会総会(Web). 2023. 110th
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Patents (56):
Education (1):
  • 1978 - 1984 National Defense Medical College Medical Science
Professional career (1):
  • M.D., Ph.D.
Work history (10):
  • 2015/10 - 現在 Sapporo Medical University Graduate School of Medicine Professor
  • 2015/10 - 現在 Sapporo Medical University School of Medicine Medical Sciences Professor
  • 2004/10 - 2015/10 Sapporo Medical University Graduate School of Medicine Associate Professor
  • 1997/11 - 2015/10 Sapporo Medical University School of Medicine Medical Sciences Assistant Professor and Associate Professor
  • 1993/08 - 1997/11 Japan Self Defense Force Sapporo General Hospital Division of Surgical Pathology Pathologist
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Awards (10):
  • 2023/02 - Hokkaido Prefecture Hokkaido Scientific Technology Prize
  • 2022/09 - The Akiyama Life Science Foundation The Akiyama Foundation Prize
  • 2014 - Ono Cancer Research Foundation Research Grant
  • 2014 - NOASTEC Foundation Research and Development Grant
  • 2007/10 - The Japanese Society of Pathology Academic Research Award
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Association Membership(s) (7):
日本宇宙生物学会 ,  Cell Stress Society International ,  American Association for Cancer Research ,  The Japanese Society for Immunology ,  The Japanese Society of Pathology ,  The Japanese Cancer Association ,  Japanese Association of Cancer Immunology
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