Rchr
J-GLOBAL ID:200901040936395104   Update date: Nov. 20, 2024

Ishii Naohito

イシイ ナオヒト | Ishii Naohito
Affiliation and department:
Job title: Professor
Other affiliations (1):
Research field  (5): Other ,  Pathobiochemistry ,  Nephrology ,  Metabolism and endocrinology ,  Respiratory medicine
Research keywords  (14): 臨床化学 ,  Clinical Chemistry ,  病態検査学 ,  腎臓生理学 ,  近位尿細管 ,  糖尿病 ,  糖尿病性腎症 ,  酸化ストレス ,  ニトロチロシン ,  ミトコンドリア ,  マイトファジー ,  リソソーム ,  リソファジー ,  呼吸生理学
Research theme for competitive and other funds  (16):
  • 2024 - 2027 ミトコンドリア品質管理機構と脂肪酸代謝に着目した糖尿病性腎症の早期診断法の開発
  • 2023 - 2026 Development of novel biomarkers for AKI-to-CKD transition by focusing on hypoxia-induced tubular regeneration.
  • 2023 - 2026 The mechanisms for renal protection by klotho protein supplementation
  • 2021 - 2024 ミトコンドリアとリソソームの品質管理に着目した糖尿病性腎症の早期診断法の開発
  • 2020 - 2022 クロト蛋白補充による腎保護についての研究
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Papers (40):
  • Yoshifumi Kurosaki, Toshihide Matsumoto, Takayuki Uematsu, Fumitaka Kawakami, Rei Kawashima, Shun Tamaki, Motoki Imai, Takafumi Ichikawa, Naohito Ishii, Hidero Kitasato, et al. SARS-CoV-2 infection causes a decline in renal megalin expression and affects vitamin D metabolism in the kidney of K18-hACE2 mice. Scientific reports. 2024. 14. 1. 24313-24313
  • Tsuneo Takenaka, Arif Hasan, Takeshi Marumo, Tsutomu Inoue, Takashi Miyazaki, Hiromichi Suzuki, Yoshifumi Kurosaki, Naohito Ishii, Akira Nishiyama, Matsuhiko Hayashi. Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney. Kidney & blood pressure research. 2023
  • Yoshifumi Kurosaki, Akemi Imoto, Fumitaka Kawakami, Motoshi Ouchi, Asuka Morita, Masanori Yokoba, Tsuneo Takenaka, Takafumi Ichikawa, Masato Katagiri, Rikke Nielsen, et al. In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells. Molecular and cellular biochemistry. 2022. 477. 3. 689-699
  • Tomoaki Tsukushi, Ryota Shinohara, Yuzuru Adachi, Yoshifumi Kurosaki, Naohito Ishii, Masato Katagiri, Shinichi Munekata, Yuhsaku Kanoh. Air contamination of therapeutic drug monitoring assay reagents results in falsely high plasma ammonia levels. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 2022. 000456322210745-000456322210745
  • Tsuneo Takenaka, Arif Hasan, Takeshi Marumo, Hiroyuki Kobori, Tsutomu Inoue, Takashi Miyazaki, Hiromichi Suzuki, Akira Nishiyama, Naohito Ishii, Matsuhiko Hayashi. Klotho supplementation attenuates blood pressure and albuminuria in murine model of IgA nephropathy. Journal of hypertension. 2021. 39. 8. 1567-1576
more...
MISC (2):
Books (2):
  • Altered renal microvascularture function in early diabetes.
    In: Contemporary Diabetes - The Diabetic Kidney, edited by Cortes P and Mogensen CE. Totowa, NJ: Humana Press. 2006
  • Effect of in vivo glucose loading on urinary enzyme excretion in rats
    In: Progress in Clinical Biochemistry, edited by Miyai K, Kanno T, Ishikawa E,Elsevier Science Publishers B.V. 1992
Lectures and oral presentations  (61):
  • Lysosomal quality control-related renal and proximal tubular protection during the normoalbuminuric stage of diabetes mellitus.
    (The 17th Asia-Pacific Federation for Clinical Biochemistry and Laboratory (APFCB) Congress 2024, Sydney, Australia 2024)
  • Stress-elevated HSP72 activates platelets and promotes thrombus formation.
    (The 17th Asia-Pacific Federation for Clinical Biochemistry and Laboratory (APFCB) Congress 2024, Sydney, Australia 2024)
  • Mitochondrial and lysosomal quality control mechanisms in renal cortex during the normoalbuminuric stage of diabetes mellitus.
    (Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT, Kyoto, Japan 2024)
  • Proteinuria causes excessive proliferation and senescence in proximal tubular cells via receptor-mediated endocytosis.
    (The 61st ERA (European Renal Association) Congress, Stockholm & Virtual, Sweden 2024)
  • Oxidative stress-related mitochondrial and lysosomal quality control mechanisms in renal cortex during the normoalbuminuric stage of diabetes mellitus.
    (Kidney Week 2023, American Society of Nephrology (ASN), Philadelphia, USA 2023)
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Education (2):
  • Kitasato University
  • Kitasato University
Professional career (2):
  • Doctor of Pharmaceutical Science (Tokyo University of Pharmacy and Life Sciences)
  • Master of Arts (Kitasato University)
Work history (6):
  • 2013/04 - 現在 北里大学大学院医療系研究科・教授
  • 2013/04 - 現在 北里大学医療衛生学部・教授
  • 2005/04 - 2013/03 北里大学大学院医療系研究科・講師
  • 2005/04 - 2013/03 北里大学医療衛生学部・講師
  • 1998/08 - 2005/03 北里大学医療衛生学部・助手
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Committee career (17):
  • 2023 - 現在 日本臨床検査学教育協議会 国際協力委員会 担当理事
  • 2023 - 現在 日本臨床検査学教育協議会 理事
  • 2023 - 現在 日本臨床化学会 常務理事
  • 2023 - 現在 日本臨床化学会 理事
  • 2022 - 現在 日本臨床化学会 若手育成委員会
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Awards (5):
  • 2008 - 2008 National Academy of Clinical Biochemistry (NACB) Distinguished Abstract Awards, American Association for Clinical Chemistry, AACC)
  • 2003 - 北里大学 学術奨励研究
  • 2002 - 日本臨床化学会 学術賞
  • 2002 - 北里大学 学術奨励研究
  • 2001 - 日本臨床化学会 奨励賞
Association Membership(s) (10):
日本電気泳動学会 ,  日本ワンヘルスサイエンス学会 ,  日本プロテオーム学会 ,  日本臨床検査学教育協議会・日本臨床検査学教育学会 ,  The American Association for Clinical Chemistry(AACC, アメリカ臨床化学会) ,  日本ミトコンドリア学会 ,  日本生化学会 ,  日本臨床検査医学会 ,  日本腎臓学会 ,  日本臨床化学会
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