Rchr
J-GLOBAL ID:200901041432733048   Update date: Sep. 20, 2024

Miyoshi Daisuke

ミヨシ ダイスケ | Miyoshi Daisuke
Affiliation and department:
Job title: Professor
Research field  (5): Biochemistry ,  Electronic devices and equipment ,  Nano/micro-systems ,  Nanobioscience ,  Nanomaterials
Research keywords  (35): 生命科学 ,  核酸化学 ,  生命機能工学 ,  ナノ粒子 ,  分子クラウディング ,  金属イオン ,  バイオセンサー ,  ヒストン ,  ナノテクノロジー ,  ナノバイオ ,  DDS ,  生体モデル化学 ,  nanoparticle ,  nanotechnology ,  nanobiotechnology ,  functional material ,  molecular crowding ,  kinetics ,  thermodynamics ,  G-quadruplex ,  peptide ,  RNA ,  peptide ,  DNA ,  Phase separation ,  -DNA ,  テロメア ,  細胞環境化学 ,  生命分子化学 ,  DNA ,  telomere ,  Nanotechnology ,  Biotechnology ,  Life Science ,  biomolecular chemistry
Research theme for competitive and other funds  (30):
  • 2021 - 2024 Model system for nucleic acid-protein liquid-liquid phase separation
  • 2020 - 2022 Formation and function of nucleolus depending on rRNA G-quadruplexes
  • 2019 - 2022 核酸四重らせん構造リガンドを用いた細胞内相分離現象の制御
  • 2019 - 2021 核酸四重らせん構造リガンドを用いた細胞内相分離現象の制御
  • 2018 - RNA四重らせん構造によるストレス顆粒の制御
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Papers (98):
  • Kohei Yokosawa, Mitsuki Tsuruta, Shinji Kajimoto, Naoki Sugimoto, Daisuke Miyoshi, Takakazu Nakabayashi. Quantification of the concentration in a droplet formed by liquid-liquid phase separation of G-quadruplex-forming RNA. Chemical Physics Letters. 2023. 826. 140634-140634
  • Yoshiki Hashimoto, Yoshiki Imagawa, Kaho Nagano, Ryuichi Maeda, Naho Nagahama, Takeru Torii, Natsuki Kinoshita, Nagisa Takamiya, Keiko Kawauchi, Hisae Tatesishi-Karimata, et al. Simple and fast screening for structure-selective G-quadruplex ligands. Chemical communications (Cambridge, England). 2023. 59. 33. 4891-4894
  • Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi. Controlling liquid-liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner. Chemical communications (Cambridge, England). 2022. 58. 93. 12931-12934
  • Wataru Sugimoto, Natsuki Kinoshita, Minori Nakata, Tatsuya Ohyama, Hisae Tateishi-Karimata, Takahito Nishikata, Naoki Sugimoto, Daisuke Miyoshi, Keiko Kawauchi. Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene. Chemical Communications. 2022. 58. 1. 48-51
  • 杉本渉, 橋本佳樹, 川内敬子, 三好大輔. Molecularly targeted photodynamic therapy for cancer mRNAs. Bio Clinica. 2021. 36. 5. 65-67
more...
MISC (83):
  • 鶴田充生, 取井猛流, 小畠一起, 川内敬子, 建石(狩俣)寿枝, 杉本直己, 三好大輔. Droplet degradation targeted at secondary structure of nucleic acid. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
  • 橋本佳樹, 取井猛流, 藤田ひな, 川内敬子, 建石寿枝, 杉本直己, 三好大輔. A Novel G4 Ligand Screening System with G4-selective Fluorescent Probe. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
  • 月生雅也, 取井猛流, 建石寿枝, 西方敬人, 杉本直己, 三好大輔, 川内敬子. Analysis of liquid-liquid phase separation phenomenon by interaction between rDNA-derived DNA G4 and RGG peptide. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
  • 取井猛流, 杉本渉, 建石寿枝, 鶴田充生, 月生雅也, 村嶋貴之, 西方敬人, 杉本直己, 三好大輔, 川内敬子. Molecular mechanism of the G-quadruplex formation for ribosomal DNA. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
  • 小畠一起, 杉本渉, 川内敬子, 杉本直己, 杉本直己, 三好大輔. Liquid-liquid phase separation of short G-quadruplex RNA oligonucleotides and RGG oligo peptides. 日本化学会春季年会講演予稿集(CD-ROM). 2020. 100th
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Patents (11):
  • 核酸鎖の四重螺旋構造の検出方法
  • テロメラーゼ活性の検出方法
  • Method for inhibiting telomerase reaction using an anionic phthalocyanine compound
  • Method for detecting G-quadruplex, method for detecting G-quadruplex-forming DNA and method for determining telomerase activity
  • 核酸を用いた紫外線吸収剤
more...
Books (18):
  • 核酸化学ハンドブック
    日本核酸化学会 2020
  • 相分離生物学の全貌
    東京化学同人 2020 ISBN:9784807913466
  • Cell and Molecular Mechanics in Health and Disease
    Hindawi Limited 2017
  • Chapter 6. Assays for Telomerase Activity toward Applications of Cancer Diagnosis in G-Quadruplex Structures, Formation and Role in Biology
    Nova Science Publishers 2016
  • DNA G-quadruplexes for organic nanomatrials
    2015
more...
Lectures and oral presentations  (138):
  • What is the canonical structure of nucleic acids in cells?
    (Institute Seminar, National Institute of Technology, Nagaland 2018)
  • DNA and RNA G-quadruplexes under molecular crowding conditions
    (IGIB seminar 2018)
  • DNA and RNA G-quadruplexes: structure, function, and ligand under cell-mimicking molecular crowding conditions
    (International Conference on Current Trends in Materials Science and Engineering (CTMSE 2018) 2018)
  • RNA foldingにおける三次元的相互作用の共存溶質による安定化効果
    (ConBio2017(第40回日本分子生物学会年会) 2017)
  • Development of cell nucleus mimicking system based on molecular crowding effects on DNA structures
    (2nd International Symposium on Biofunctional Chemistry (ISBC2017) 2017)
more...
Works (121):
  • ケミカルバイオロジー2.0
    2019 -
  • G-Quadruplex: a Versatile DNA structure in vivo and in vitro
    2007 -
  • Conformational switch of a functional nanowire based on the DNA G-quadruplex
    2007 -
  • Effects of cosolutes on the thermodynamic stability of parallel DNA duplex and triplex
    2007 -
  • Functional DNA materials controlled by surrounding conditions
    2007 -
more...
Education (2):
  • - 2003 Konan University Graduate School, Division of Science and Technology
  • - 1996 Konan University Faculty of Science
Professional career (1):
  • 博士(理学) (甲南大学)
Work history (5):
  • 2015/04/01 - 現在 KONAN UNIVERSITY Faculty of Frontiers of Innovative Research in Science and Technology Faculty of Frontiers of Innovative Research in Science and Technology Department of Nanobiochemistry Professor
  • 2009/04/01 - 2015/03/31 KONAN UNIVERSITY Faculty of Frontiers of Innovative Research in Science and Technology Faculty of Frontiers of Innovative Research in Science and Technology Department of Nanobiochemistry Associate Professor
  • 2004/04/01 - 2009/03/31 KONAN UNIVERSITY Lecturer
  • 2003/04/01 - 2004/03/31 米国イリノイ大学アーバナ・シャンペーン校 博士研究員
  • Konan University Frontier Institute for Biomolecular Engineering Research Assistant Professor
Committee career (9):
  • 2019/04 - 現在 日本化学会 CSJ化学フェスタ 実行委員
  • 2017/04 - 現在 日本核酸化学学会 評議員
  • 2016/05 - 現在 日本ナノメディシン交流協会 理事
  • 2019/12 - 日本ナノメディシン交流協会 13th Anniversary International Symposium on Nanomedicine (ISNM2019)実行委員長
  • 2019/10 - 日本生物物理学会 第57回日本生物物理学会年会 シンポジウムオーガナイザー
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Awards (6):
  • 2015/03 - 村尾育英会 村尾育英会学術賞
  • 2013/10 - バイオインダストリー協会 化学・生物素材研究開発奨励賞
  • 2011/11/01 - The organizing committee and executive committee of the 38th International Symposium on Nucleic Acid Chemistry (ISNAC2011) ISNAC Outstanding Oral Presentation Award for Young Scientist in 2011
  • 2011/03/01 - 日本化学会 日本化学会第91春季年会 若い世代の特別講演賞
  • 2007/09/01 - 日本化学会 日本化学会 生体機能関連化学 シンポジウム講演賞
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Association Membership(s) (6):
日本化学会 ,  Chemical Society of Japan ,  生命化学研究会 ,  生体機能化学部会 ,  バイオテクノロジー部会 ,  米国化学会
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