Iwai Shigenori

イワイシゲノリ | Iwai Shigenori

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.chem.es.osaka-u.ac.jp/bio/

Research field (3)： Molecular biology , Synthetic organic chemistry , Molecular biochemistry

Research theme for competitive and other funds (25)：

2020 - 2023 Fluorescence detection of cellular ability of mismatch repair using synthetic DNA
2016 - 2021 Higher-order regulatory mechanisms for DNA damage recognition in nucleotide excision repair
2014 - 2016 Mechanisms and functions of i-RNase activity
2013 - 2016 Alternative DNA repair pathways of DNA damage induced by topoisomerase inhibitor
2011 - 2016 Cross-regulation of the maintenance and mutagenesis of genomic sequence and epigenetic information

2012 - 2015 Single-molecule direct visualization of DNA repair proteins on chromatin

2012 - 2015 Detection of structural change of DNA using disulfide bond formation and its application to elucidation of molecular recognition mechanisms

2012 - 2015 Novel molecular mechanism maintaining genomic homeostasis against environmental stresses

2010 - 2012 Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase

2009 - 2011 Detection and analysis of DNA repair using chemically-synthesized DNA sensors

2005 - 2009 Molecular mechanisms of translesion DNA synthesis and its involvement in carcinogenesis

2005 - 2007 Recognition of UV-clamaged DNA by antinoglycoside antibiotics

2003 - 2004 Search for low-molecular-weight compounds that specifically bind UV-damaged DNA

2000 - 2003 Development of functional analysis of genes in cells using functional nucleic acids

1994 - 1994 核磁気共鳴によりリボヌクレアーゼHの基質認識機構の解析

1994 - 1994 修飾オリゴヌクレオチドを用いた紫外線損傷DNA修復機構の解析

1993 - 1994 Photodamage repair of DNA by anti thymine dimer antibody

1993 - 1993 紫外線損傷塩基を含む化学合成オリゴヌクレオチドと修復酵素との相互作用の解析

1993 - 1993 紫外線誘発DNA損傷による発癌遺伝子活性化に関する研究-化学合成オリゴヌクレオチドを用いた部位特異的導入法によるアプローチ

1990 - 1990 T4エンドヌクレア-ゼVの基質認識機構の解析

1990 - 1990 チミンダイマ-除去修復機構の合成遺伝子による解析

1989 - 1990 Elucidation of the Mechanism for the Self-Cleavage Rection of RNA Using Chemically-Synthesized Oligonucleotides

1987 - 1988 Development of site-specific RNA cleaving method using modified DNA splints-RNase H system

1986 - 1986 合成遺伝子を用いるDNA修復酵素の機能の研究

1985 - 1986 Development of cancer diagnosis using monoclonal antibodies specific for ras gene products

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Papers (251)：

Miyako Shiraishi, Noboru Nabeshima, Keiichiro Suzuki, Masatoshi Fujita, Shigenori Iwai. Endonuclease Q as a robust enhancer for nucleic acid amplification. Analytical Biochemistry. 2024. 692. 115569
Kazuki Matsubara, Shouta Ueda, Junpei Yamamoto, Shigenori Iwai, Narumi Aoki Shioi, Arato Takedachi, Isao Kuraoka. Structure-specific DNA endonuclease T7 endonuclease I cleaves DNA containing UV-induced DNA lesions. The Journal of Biochemistry. 2024. 176. 1. 35-42
Kazuma Mitsuoka, Jung In Kim, Aya Yoshida, Akane Matsumoto, Narumi Aoki-Shioi, Shigenori Iwai, Isao Kuraoka. Base preference for inosine 3′-riboendonuclease activity of human endonuclease V: implications for cleavage of poly-A tails containing inosine. Scientific Reports. 2024. 14. 14973
Shigenori Iwai, Yuta Hayashi, Tomohiro Baba, Yasutaka Kitagawa. Acceleration of hydrolytic ring opening of N7-alkylguanine by the terminal carbamoyl group of glycidamide. Chemical Communications. 2024. 60. 38. 5014-5017
Naoto Shimizu, Yusaku Hamada, Ryosuke Morozumi, Junpei Yamamoto, Shigenori Iwai, Kei-ichi Sugiyama, Hiroshi Ide, Masataka Tsuda. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding. Journal of Biological Chemistry. 2023. 104988-104988

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MISC (33)：

Kei Kunimasa, Yuya Bando, Miyako Shiraishi, Emi Aizawa, Kazumi Nishino, Motohiro Tamiya, Takoko Inoue, Hanako Kuhara, Hayato Kawachi, Kika Kuno, et al. Development CRISPR-Cas12-based rapid EGFR mutation detection kit. JOURNAL OF CLINICAL ONCOLOGY. 2020. 38. 15
Masayuki Kusakabe, Yuki Onishi, Haruto Tada, Fumika Kurihara, Kanako Kusao, Mari Furukawa, Shigenori Iwai, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa. Mechanism and regulation of DNA damage recognition in nucleotide excision repair. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2019. 41. 2-2
D. Yamada, H. M. Dokainish, T. Iwata, J. Yamamoto, T. Ishikawa, T. Todo, S. Iwai, E. D. Getzoff, K. Yura, A. Kitao, et al. Function conversion between CPD and (6-4) photolyases. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S82-S82
D. Yamada, H. M. Dokainish, T. Iwata, J. Yamamoto, T. Ishikawa, T. Todo, S. Iwai, E. D. Getzoff, K. Yura, A. Kitao, et al. Function conversion between CPD and (6-4) photolyases. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S276-S276
D. Yamada, T. Iwata, J. Yamamoto, T. Ishikawa, E. D. Getzoff, T. Todo, S. Iwai, H. Kandori. Asymmetrical functional conversion of (6-4) photolyase and CPD photolyase. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2015. 44. S66-S66

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Education (2)：

1982 - 1984 Osaka University
1978 - 1982 Osaka University School of Pharmaceutical Sciences

Work history (4)：

2001 - 2003 東京大学大学院助教授
1995 - 2001 生物分子工学研究所主任研究員
1988 - 1995 Hokkaido University
1984 - 1988 Hokkaido University

Association Membership(s) (3)：

日本化学会 , 日本分子生物学会 , 日本薬学会

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