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J-GLOBAL ID：200901042960344530 Update date: Feb. 14, 2025

Miyazaki Yasushi

ミヤザキヤスシ | Miyazaki Yasushi

Affiliation and department：
Job title： Professor

Research field (1)： Hematology and oncology

Research keywords (4)：放射線影響 , 血液内科学 , Radiation hematology , Hematology

Research theme for competitive and other funds (26)：

2019 - 2024 Clinical application of germline and somatic mutations in bone marrow failure syndromes.
2020 - 2023 t(8;21)およびinv(16)陽性AYA・若年成人急性骨髄性白血病に対する微小残存病変を指標とするゲムツズマブ・オゾガマイシン治療介入の有効性と安全性を評価する研究
2020 - 2023 Study for the mechanism of onset for myelodysplastic syndromes among atomic bomb survivors through temporal axis
2017 - 2020 原爆被爆者の腫瘍性/非腫瘍性造血に見られるゲノム異常の包括的解析
2016 - 2019 Epidemiological and molecular biological study of therapy-related myeloid neoplasms

2016 - 2019 全ヒトゲノム配列で明らかにする放射線被ばく影響の時間的経過とその結果

2015 - 2018 Exploration new biomarkers based on HTLV-1 carrier clone analysis

2017 - 2018 日本成人白血病治療研究グループ(Japan Adult Leukemia Study Group, JALSG)による国内成人白血病に対する多施設共同研究の推進

2014 - 2017 原爆被爆者に見られる骨髄異形成症候群の臨床的特徴と遺伝子変化の解明

2011 - 2015 Risk evaluation based on the clinical characteristics of Hematological malignancies in atomic bomb survivors

2010 - 2012 Analysis of anti-tumor activity and anti-virus effect after allogeneic hematopoietic stem cell transplantation for patients with ATL

2010 - 2012 Interaction between NPM1 which is deeply related with the prognosisof leukemia and the ETS family of transcription factor, MEF

2008 - 2012 Epigenome analysis of cancer

2008 - 2010 Risk assessment based on the clinical characteristics of leukemia and the related disorders in atomic bomb survivors

2008 - 2010 Chimerism analysis in fingernails among recipients of allogeneic hematopoietic stem-cell transplants by examining the patterns of the short tandem repeat.

2007 - 2009 The diagnosis of acute myeloid leukemia based on the new WHO classification in the multicenter study.

2004 - 2005 Characterization of side population cells in bone marrow of myelodysplastic syndrome, aplastic anemia, and paroxysmal nocturnal hemoglobinuria.

2003 - 2005 New system of central diagnoses of acute myeloid leukemia in the multi-institutional cooperative study.

2003 - 2005 Development of a new classification for AML based on the gene expression profile in leukemia stem cells.

2003 - 2004 The analysis of cell lineage specific expression of perforin gene

1998 - 造血器悪性腫瘍の治療学

1998 - 血液悪性腫瘍の生物学

1998 - 造血幹細胞移植を用いた血液疾患の治療

1998 - Treatment of hematological malignancies

1998 - Biology of hematological malignancies

1998 - Therapy of Hematological Diseases by Hematopoietic Stem Cell Transplantation

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Papers (482)：

Hidehiro Itonaga, Yasushi Miyazaki, Takeshi Kondo, Yutaka Shimazu, Jun Aoki, Shuhei Kurosawa, Takashi Ikeda, Tetsuya Eto, Naoyuki Uchida, Hideyuki Nakazawa, et al. Long-Term Survival After Allogeneic Hematopoietic Stem Cell Transplantation for BCR::ABL1-Negative Atypical Chronic Myeloid Leukemia: A Nationwide Retrospective Study by Adult CML/MPN and MDS Working Groups of the Japanese Society for Transplantation and Cellular Therapy. American journal of hematology. 2025
Yuichi Yamada, Hiroaki Miyoshi, Mai Takeuchi, Kazutaka Nakashima, Kyohei Yamada, Takeharu Kato, Ken Tanaka, Kei Kohno, Yoshitaka Imaizumi, Yasushi Miyazaki, et al. TIGIT expression on neoplastic cells is a poor prognostic factor for adult T-cell leukaemia/lymphoma. Pathology. 2024. 56. 7. 993-999
Miki Hashimoto, Takeharu Kato, Kenichi Yokota, Hikaru Sakamoto, Makiko Horai, Masataka Taguchi, Hidehiro Itonaga, Shinya Sato, Maki Baba, Koji Ando, et al. Improved survival among elderly patients with aggressive adult T-cell leukemia/lymphoma: Impact of mogamulizumab-containing chemotherapy. International journal of hematology. 2024
Machiko Fujioka, Hidehiro Itonaga, Hideyuki Nakazawa, Tetsuya Nishida, Keisuke Kataoka, Takashi Ikeda, Shinichi Kako, Ken-Ichi Matsuoka, Koji Adachi, Shini-Chiro Fujiwara, et al. Superior survival after unrelated allogeneic stem cell transplantation with low-dose ATG compared to low-dose TBI in myeloablative fludarabine/busulfan-based regimen for MDS on behalf of the adult MDS Working Group of the JSTCT. Transplantation and cellular therapy. 2024
Yuji Kobayashi, Koji Ando, Yoshitaka Imaizumi, Hikaru Sakamoto, Hideaki Kitanosono, Masataka Taguchi, Hiroyuki Mishima, Akira Kinoshita, Shara Bekytbek, Maki Baba, et al. RUNX1 expression is regulated by a super-enhancer and is a therapeutic target in adult T-cell leukemia/lymphoma. Leukemia & lymphoma. 2024. 1-13

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MISC (328)：

上原裕規, 増田真吾, 増田真吾, 福井翔一, 渡邉裕史郎, 小笹宗一郎, 赤羽目翔悟, 山梨啓友, 岩本直樹, 坂本光, et al. サーモンピンク疹を伴い,成人still病との鑑別を要した血管内リンパ腫の一例. 日本病院総合診療医学会雑誌(Web). 2023. 19
June Takeda, Kenichi Yoshida, Masahiro M. Nakagawa, Yasuhito Nannya, Akinori Yoda, Ryunosuke Saiki, Yotaro Ochi, Lanying Zhao, Rurika Okuda, Xingxing Qi, et al. Amplified EPOR/JAK2 genes definea unique subtype of acute erythroid leukemia. CANCER RESEARCH. 2022. 82. 12
Shinobu Tsuzuki, Takahiko Yasuda, Masahito Kawazu, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Masashi Sanada, Hirokazu Nagai, Akihiro Tomita, Yoshiyuki Takahashi, et al. Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. CANCER SCIENCE. 2022. 113. 1236-1236
中崎久美, 竹崎俊晶, 正本庸介, 宮崎泰司, 三谷絹子, 黒川峰夫. 低リスク骨髄異形成症候群の治療選択と予後全国多施設共同研究. 日本内科学会雑誌. 2022. 111. Suppl. 183-183
西村紗央里, 加藤丈晴, 糸永英弘, 佐藤信也, 安東恒史, 澤山靖, 三好寛明, 今泉芳孝, 大島孝一, 宮崎泰司. 口腔内に生じたHIV陰性・EBV陰性の形質芽球性リンパ腫. 臨床血液. 2022. 63. 6

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Books (15)：

別冊日本臨床血液症候群(第3版)
株式会社日本臨床社 2024
血液専門医テキスト = Textbook of Hematology
南江堂 2023 ISBN:9784524203710
造血器腫瘍診療ガイドライン
金原出版 2023 ISBN:9784307102247
未来型血液治療学
中外医学社 2019 ISBN:9784498225183
血液専門医テキスト
南江堂 2019 ISBN:9784524248827

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Lectures and oral presentations (53)：

Clonal Evolution of Der(1;7)(q10;p10) Myeloid Neoplasms.
(65th ASH Annual Meeting and Exposition 2023)
Data-Driven Harmonization of 2022 Who and ICC Classifications of Myelodysplastic Syndromes/Neoplasms (MDS): A Study By the International Consortium for MDS (icMDS).
(65th ASH Annual Meeting and Exposition 2023)
Molecular Measurable Residual Disease (MRD) Clearance (≤1%) Is Associated with Improved Clinical Outcomes in Patients with Higher-Risk Myelodysplastic Neoplasms (HR-MDS): An Exploratory Analysis of Stimulus-MDS1 in Patients Receiving Sabatolimab or Placebo + Hypomethylating Agent (HMA)
(65th ASH Annual Meeting and Exposition 2023)
Phase 1/2 First-in-Human Study of the Menin-MLL Inhibitor DSP-5336 in Patients with Relapsed or Refractory Acute Leukemia
(65th ASH Annual Meeting and Exposition 2023)
Long-term effects of radiation on hematopoiesis among Atomic Bomb survivors.
(International Charles Heidelberger Symposium on Cancer Research, 2023 2023)

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Works (8)：

HIV・HCV重複感染血友病患者の長期療養に関する患者参加型研究
2010 - 2014
DNAチップによる急性白血病の新規分類法提案
2010 - 2013
白血病予後を司るNPM1とETS遺伝子MEFとの相互作用の解明
2010 - 2013
HIV関連リポディストロフィーへの脂肪由来幹細胞移植時における凝固能管理と臨床経過検討
2009 - 2011
成人白血病の難治機構の分子レベルでの解明とそれに基づく分子標的治療の開発に関する研究
2009 - 2011

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Education (2)：

- 1986 Nagasaki University School of Medicine
- 1986 Nagasaki University Faculty of Medicine

Professional career (1)：

PhD. (Nagasaki University)

Work history (5)：

2013/04 - 現在 Nagasaki University
2017/04 - 2023/03 Nagasaki University
2011/10 - 2017/03 Nagasaki University Hospital
2009/09 - 2013/03 Nagasaki University Graduate School of Biomedical Sciences
2004/01 - 2009/08 Nagasaki University Hospital

Committee career (15)：

2024/04 - 現在日本内科学会理事
2016/09 - 現在日本血液学会教育委員長
2010 - 現在日本血液学会理事
2008 - 現在骨髄移植推進財団ドナー安全委員(2007)
2010 - 長崎原子爆弾被爆者対策協議会理事(2009)

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Association Membership(s) (18)：

日本輸血・細胞治療学会 , 日本検査血液学会 , 日本癌治療学会 , 日本臨床腫瘍学会 , 日本造血・免疫細胞療法学会 , アメリカ血液学会 , 日本癌学会 , 日本血液学会 , 日本内科学会 , The Japanese Society of Transfusion Medicine and Cell Therapy , Japanese Society for Laboratory Hematology , Japanese Society of Clinical Oncology , Japanese Society of Medical Oncology , Japanese Society for Hematopoietic Cell Transplantation , American Society of Hematology , Japanese Cancer Association , Japanese Society of Hematology , Japanese Society of Internal Medicine

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