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J-GLOBAL ID：200901044470222013 Update date: Mar. 05, 2025

Kuniaki Saito

サイトウクニアキ | Kuniaki Saito

Affiliation and department：
Other affiliations (1)：

Kyoto University

Research field (5)： Neuroscience - general , Healthcare management, medical sociology , Pathobiochemistry , Nutrition and health science , Other

Research theme for competitive and other funds (40)：

2023 - 2026 Mechanisms of peripheral-CNS immune responses in the development of major depressive disorder induced by stress
2023 - 2026 多角的なSARS-CoV-2免疫獲得状況の調査研究
2022 - 2025 トリプトファン代謝制御を利用した慢性HBV感染症に対する治療的ワクチン療法の開発
2022 - 2025 時系列データベースを活用した生活習慣病予測モデルの構築および検証
2020 - 2023 Development of a new diagnostic technique for idiopathic interstitial pneumonia based on a synthesis of patient images

2019 - 2022 Elucidation of the role of tryptophan metabolism in diabetic nephropathy: Towards a development of novel treatment of diabetic nephropathy targeting tryptophan metabolism

2017 - 2022 Development of the next-generation diagnosis method for depression by using byomakers based on pathophysiological mechanism

2018 - 2021 Relationship between changes in amino acid metabolism during pregnancy and postpartum depression.

2017 - 2020 Analysis of carcinogenesis originated from chronic inflammation in malignant lymphoma

2017 - 2019 Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through regulation of IL-6/stat3 signalling

2015 - 2018 Tryptophan metabolic profile is effective for preemptive medicine in depression symptoms

2015 - 2018 Omics analysis applicable to preemptive medicine of chronic kidney disease -focusing on comprehensive analysis of phosphorylated proteins-

2014 - 2017 Antitumor efficacies of indoleamine 2,3-dioxygenase 2 in lewis lung carcinoma mice model.

2014 - 2017 The effects of NKT cell-mediated immunotherapy by IDO inhibitor in mouse lung metastasis model

2013 - 2017 The role of synaptic vesicle protein 2A (SV2A) in the pathophysiology and treatment of Autism spectrum disorders

2014 - 2016 Increased serum GP88 (Progranulin) concentrations in rheumatoid arthritis.

2012 - 2014 The investigation of immune regulation by IDO in NKT cell-mediated immunotherapy

2011 - 2014 Increases in Tryptophan-kynurenine pathway metabolism following interferon-induced depression

2011 - 2012 Studies on thescale for stress induced emotional changes

2010 - 2012 Role of indoleamine-2,3-dioxygenase in atherosclerotic carotid artery stenosis

2009 - 2012 Screening and gene analysis for the protection from muscle damage by statin drugs

2008 - 2011 The pathophysiologic role of indoleamine 2, 3-dioxygenase in viral infectious diseases

2008 - 2010 Development of device using color images to reduce stress in cancer and/or other chronic disease patients.

2006 - 2007 Study on the mechanism of rhabdomyosis induced by statins and gene analysis of patients with rhalxiomyasis

2005 - 2007 Study on analytical system for the etiology of autoimmune disease using two-dimensional nano LC/MS

2002 - 2004 マウス骨髄移植技術を用いた肝不全発症機構の解明とその臨床応用に関する研究

2002 - 2003 The role of proinflammatory cytokines in the generation of myocardial ischemia/reperfusion injury

2002 - 2003 Proteome analysis of human macrophage cells associated with atherosclerosis

2001 - 2003 Study on the mechanism of atherosclerotic lesion formation using cytokine-knockout mouse

2001 - 2002 A mechanism of HIV-related dementia complex - relation between TNF-α and dementia -

1999 - 2001 The method for determination of serum lipid-free apolipoprotein concentration and its clinical application

1999 - 2000 A study of the role of cytokines in the development of atherosclerosis using double knockout mice

1998 - 2000 Significance of soluble Fas and its related cytokines in serum of rheumatoid arthritis patients.

1998 - 1999 The role of proinflammatory cytokines in the development and progression of viral myocarditis

1998 - 1999 TNF-αノックアウトマウスを用いたエイズ痴呆コンプレックス発症機構に関する研究

1995 - 1997 Basic studies of immunotherapy in relation to the serum soluble interleukin-2 receptor determination in patients with rheumatoid arthritis

1995 - 1996 Study on the role of Lp (a) as an acute phase reactant and on the effects on arterial endothelial and smooth muscle cells.

1995 - 1996 Study on apo A-IV polymorphism in patients with hyperlipidemia.

1995 - 1995 脳神経系疾患における組織修復と各種アポタンパク合成との関係

1994 - 1995 Study on structural heterogeneity of Lp(a) and its clinical significance.

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Papers (472)：

Masaya Hasegawa, Kazuo Kunisawa, Bolati Wulaer, Hisayoshi Kubota, Hitomi Kurahashi, Takatoshi Sakata, Honomi Ando, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, et al. Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine-3-monooxygenase with microglial decline. British Journal of Pharmacology. 2024
Masaya Hasegawa, Moe Niijima, Kazuo Kunisawa, Tomoaki Teshigawara, Hisayoshi Kubota, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Hyoung-Chun Kim, Kuniaki Saito, et al. Maternal immune activation induces neurodevelopmental impairments of adult offspring through alterations in tryptophane-kynurenine pathway in the placenta. Biochemical and Biophysical Research Communications. 2024. 737. 150922-150922
Moeka Tanabe, Kazuo Kunisawa, Imari Saito, Aika Kosuge, Hiroyuki Tezuka, Tomoki Kawai, Yuki Kon, Koyo Yoshidomi, Akari Kagami, Masaya Hasegawa, et al. Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine. Molecular Psychiatry. 2024
Hitomi Kurahashi, Kazuo Kunisawa, Kenji F. Tanaka, Hisayoshi Kubota, Masaya Hasegawa, Mai Miyachi, Yuka Moriya, Yoichi Hasegawa, Taku Nagai, Kuniaki Saito, et al. Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid. Neuropsychopharmacology. 2024
Hisayoshi Kubota, Kazuo Kunisawa, Masaya Hasegawa, Hitomi Kurahashi, Kazuhiro Kagotani, Yuki Fujimoto, Akihito Hayashi, Ryoji Sono, Takehiko Tsuji, Kuniaki Saito, et al. Soy lysolecithin prevents hypertension and cognitive impairment induced in mice by high salt intake by inhibiting intestinal inflammation. Neurochemistry international. 2024. 180. 105858-105858

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MISC (243)：

藤垣英嗣, 竹村正男, 竹村正男, 山本康子, 佐藤正夫, 四戸隆基, 石田秀和, 竹村恵里奈, 出田貴康, 清水雅仁, et al. Establishment and clinical significance of progranulin (PGRN) measurement.-Changes by TNF-related biologic agent infliximab treatment in RA patients.-. 医療検査と自動化(Web). 2024. 49. 1
杉浦彩香, 藤垣英嗣, 高尾明日香, 生野彰宏, 山本康子, 齋藤邦明. Kynurenine aminotransferase2遺伝子欠損マウスにおけるトリプトファン代謝産物量の変化. 臨床化学(Web). 2024. 53
早田光里, 藤垣英嗣, 杉浦彩香, 高尾明日香, 藤垣朱和子, 生野彰宏, 山本康子, 齋藤邦明. Metabolomic analysis of serum tryptophan metabolites in patients with COVID-19. 医療検査と自動化(Web). 2024. 49. 4
杉浦彩香, 藤垣英嗣, 高尾明日香, 早田光里, 生野彰宏, 山本康子, 竹村正男, 齋藤邦明. Differences in Anti-SARS-CoV-2 antibody response after vaccination in presence or absence of infection. 医療検査と自動化(Web). 2024. 49. 4
高尾明日香, 藤垣英嗣, 酒井好美, 杉浦彩香, 早田光里, 田坂正綱, 生野彰宏, 山本康子, 竹村正男, 齋藤邦明. SARS-CoV-2 seroprevalence in the early and late phase of the COVID-19 pandemic. 医療検査と自動化(Web). 2024. 49. 4

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Patents (5)：

Books (7)：

わかりやすい生化学-疾病と代謝・栄養の理解のために
ヌーヴェルヒロカワ 2017 ISBN:9784861740695
Tumor Necrosis Factor:Structure,Enzyme Regulation and Role in Health and Disease
Nova Science Publishers 2013
遺伝子分析科学
宇宙堂八木書店 2011
健康食品ポケットマニュアル
日本食品安全協会 2010
臨床検査ポケットレビュー帳
メジカルビュー社 2009

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Lectures and oral presentations (25)：

液体クロマトグラフ質量分析計(LC-MS)によるトリプトファン代謝産物一斉定量解析
(臨床化学 2019)
全自動化学発光免疫測定装置によるIL-6測定に関する基礎的検討
(日本臨床検査自動化学会会誌 2019)
Mask R-CNNを用いた小児胸部X線画像における肺領域の自動抽出
(日本医用画像工学会大会予稿集 2019)
液状細胞診画像と患者情報の併用による肺癌組織型自動分類の基礎的検討
(日本医用画像工学会大会予稿集 2019)
2型糖尿病性腎症モデルラットにおける腎組織中キノリン酸の分布解析
(日本腎臓学会誌 2019)

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Professional career (1)：

医学博士

Work history (7)：

2015 - 現在 Fujita Health University
2006 - 2015 Kyoto University Graduate School of Medicine Professor
2004 - 2006 Gifu University Associate Professor
2002 - 2004 National Institute of Mental Health Laboratory of Neurotoxicology Visiting Scientist
1997 - 2002 Gifu University University Hospital

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Committee career (7)：

- 現在一般社団法人奥伊勢バイオサイエンスセンター理事
- 現在一般社団法人日本臨床検査教育協議会副理事長
- 現在一般社団法人日本食品安全協会理事
- 現在特定非営利活動法人医薬品適正使用推進機構理事
- 現在一般社団法人日本臨床化学会理事

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Awards (2)：

一般社団法人日本臨床検査医学会学会賞
一般社団法人日本臨床化学会学術賞

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