Rchr
J-GLOBAL ID：200901044597255395   Update date: Oct. 19, 2024

Deguchi Yoshiharu

デグチ ヨシハル | Deguchi Yoshiharu
Affiliation and department：
Teikyo University Faculty of Pharmaceutical Sciences, Drug Disposition and Pharmacokinetics

About Teikyo University Faculty of Pharmaceutical Sciences, Drug Disposition and Pharmacokinetics


Job title： Professor
Research field  (1)： Clinical pharmacy
Research keywords  (17)： hiPS-BMECs ,  human iPS cells ,  血液脳関門 ,  トランスポーター ,  ヒト血液脳関門不死化細胞株 ,  脳移行性 ,  排出輸送 ,  脳保護機 ,  脳細胞間液 ,  トランスサイトーシス ,  有機カチオントランスポーター ,  脳移行性改善法 ,  薬物送達学 ,  CNS barrier ,  薬物動態学 ,  Drug Delivery System ,  Pharmacokinetics
Research theme for competitive and other funds  (24)：
  • 2022 - 2025 Creation and clinical application of 3D brain barrier chips using human iPS cells
  • 2019 - 2021 iPS細胞由来脳毛細血管内皮細胞を用いたヒト血液脳関門の実体解明
  • 2015 - 2018 Transport aross the blood-brain barrier in relation to CNS actions of opioid analgesics
  • 2016 - 2018 ヒト血液脳関門有機カチオン-プロトン交換輸送系の薬物認識性と実体の解明
  • 2012 - 2016 超音波セラノスティックスシステムの実用化を目指す研究拠点の形成
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Papers (129)：
  • Yasuyuki Debori, Tomoko Igari, Masanori Nakakariya, Hideki Hirabayashi, Kazunobu Aoyama, Nobuyuki Amano, Toshiki Kurosawa, Yoshiyuki Kubo, Yoshiharu Deguchi. Involvement of Proton-Coupled Organic Cation Antiporter in Human Blood-Brain Barrier Transport of Mesoridazine and Metoclopramide. Biological & pharmaceutical bulletin. 2024. 47. 10. 1662-1667
  • Tomoko Yamaguchi, Daiki Sako, Toshiki Kurosawa, Misae Nishijima, Ayaka Miyano, Yoshiyuki Kubo, Sumio Ohtsuki, Kenji Kawabata, Yoshiharu Deguchi. Development and Functional Evaluation of MDR1-Expressing Microvascular Endothelial-Like Cells Derived from Human iPS Cells as an In Vitro Blood-Brain Barrier Model. Journal of pharmaceutical sciences. 2023
  • Toshiki Kurosawa, Daiki Sako, Yoshiyuki Kubo, Yoshiharu Deguchi. ヒトiPS細胞由来血液脳関門モデルの構築とトランスポーター機能評価. Drug Delivery System. 2023. 38. 2. 117-124
  • Toshiki Kurosawa, Yuma Tega, Yasuo Uchida, Kei Higuchi, Hidetsugu Tabata, Takaaki Sumiyoshi, Yoshiyuki Kubo, Tetsuya Terasaki, Yoshiharu Deguchi. Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier. Pharmaceutics. 2022. 14. 8. 1683-1683
  • Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano, Yoshiharu Deguchi. Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. Pharmaceutical Research. 2022
ｍore...
MISC (215)：
  • 黒澤俊樹, 手賀悠真, 佐孝大樹, 出堀泰之, 冨原裕美, 天野信之, 出口芳春. Construction of 3D BBB model using brain microvascular endothelial cells derived from human induced pluripotent stem cells. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
  • 住吉孝明, 平中誠弥, 出口芳春, 伊藤昭博, 吉田稔. 血液脳関門透過性を有するヒストン脱アセチル化酵素阻害剤の探索. MEDCHEM NEWS. 2020. 30. 1. 43-46
  • 黒澤俊樹, 手賀悠真, 山口朋子, 川端健二, 望月達貴, 井上勝央, 楠原洋之, 出口芳春. Analysis of 6-mercaptopurine transport mechanism across blood-brain barrier model derived from human iPS cells. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35th
  • 古西修希, 伊藤慎悟, 上村立記, 増田豪, 樋口慧, 黒澤俊樹, 手賀悠真, 出口芳春, 大槻純男. Effects of Loss of P-glycoprotein of blood-brain barrier homeostasis. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35th
  • 手賀悠真, 田畑英嗣, 黒澤俊樹, 北村敦, 板垣文雄, 忍足鉄太, 出口芳春. Membrane permeability of diphenhydramine derivatives via H+/organic cation antiporter. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
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Books (17)：
  • わかりやすい薬物動態計算問題の解き方
    ネオメディカル 2019
  • エピソード薬物動態学 ー薬物動態学の解明ー 6冊
    京都廣川書店 2018
  • 添付文書が読める物理・化学
    じほう 2017
  • パートナー薬剤学 改訂第3版
    南江堂 2017
  • 薬の生体内運命(改訂7版)
    ネオメディカル 2017
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Lectures and oral presentations  (48)：
  • Expression and functional characterization of SLC transporters in brain microvascular endothelial cells derived from human induced pluripotent stem cells.
    (13th International Conference on Cerebral Vascular Biology (Miami) 2019)
  • 脳移行性評価技術としてのヒトiPS由来脳毛細血管内皮細胞の有用性と限界
    (日本薬剤学会 第34年会(富山) 2019)
  • 新しい中枢疾患モダリティを創製するためのヒト血液脳関門機能の理解
    (日本薬学会第139年会(千葉) 2019)
  • Characterization of mesoridazine transport in human cerebral microvessel endothelial cells, hCMEC/D3
    (第33JSSX第22MDO合同年会(金沢) 2018)
  • Screening of proton-coupled organic cation antiporter substrates using hCMEC/D3 cells: an in vitro human blood-brain barrier model
    (2018)
ｍore...
Works (6)：
  • Analysis of blood brain barrier transport of the narcotic drugs and its clinical application
    2004 -
  • Study on the pulmonary distribution of new quinolone antibacterials.
    2002 -
  • Analysis of the blood-brain barrier transport mechanism of a novel mu1-selective opioid peptide.
    2000 -
  • Analysis of brain distribution mechanism of a novel drug against Alzheimer's disease.
    1999 -
  • Blood-brain barrier transport mechanism of bFGF
    1998 -
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Education (6)：
  • 1997 - 1997 Post Doc Fellow in Medicine, UCLA School of Medicine
  • 1989 - 1993 金沢大学自然科学研究科 研究生
  • 1980 - 1982 Kanazawa University
  • - 1982 Kanazawa University Graduate School, Division of Pharmaceutical Sciences
  • - 1980 Kanazawa University Faculty of Pharmaceutical Sciences
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Professional career (1)：
  • Ph. D. (Kanazawa University)
Work history (5)：
  • 2005/04 - 現在 Teiko University Faculty of Pharma Sciences Professor
  • 2002/04 - 2005/03 Teikyo University Faculty of Pharma-Science
  • 2000/04 - 2002/03 Hokkaido Colledge of Pharmacy Assistant Professor
  • 1993/01 - 2000/03 University of Shizuoka School of Pharmaceutical Sciences
  • 1982/04 - 1989/06 Kanazawa University Hospital, Department of Hospital Pharmacy
Committee career (14)：
  • 2014/04 - 現在 日本薬学会関東支部 代議員
  • - 現在 Associate Editor of Biological Pharmaceutical Bulletin The Pharmaceutical Society of Japan
  • - 現在 Editorial Advisory Board of Journal of Pharmaceutical Sciences The Japanese Society of the Study of Xenobiotics
  • - 現在 日本薬剤学会 評議員
  • - 現在 Associate Editor of Drug Metabolism and Pharmacokinetics The Japanese Society for the Study of Xenobiotics
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Awards (5)：
  • 2020/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award for Divisional Scientific Contribution
  • 2014/12 - American Pharmacist Association Top Reviewers of J. Pharm. Sci.
  • 2009/03 - American Pharmacist Association Top Reviewer of J. Pharm. Sci.
  • 2001 - 日本薬物動態学会奨励賞
  • 2001 - The Encouraging Prize of Japanese Society for the Study of Xenobiotics
Association Membership(s) (13)：
The Asian Federation for Pharmaceutical Sciences ,  Sozai Forum ,  JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES ,  米国薬学会 ,  日本DDS学会 ,  日本薬剤学会 ,  日本薬物動態学会 ,  日本薬学会 ,  American Association of Pharmaceutical Scientists. ,  The Japan Society of Drug Delivery System. ,  The Academy of Pharmaceutical Science and Technology, Jpan ,  Japanese Society for the Study of Xenobiotics. ,  The Pharmaceutical Society of Japan.
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