WAGA Shou

ワガショウ | WAGA Shou

Affiliation and department：
Homepage URL (1)： http://mcm-www.jwu.ac.jp/~waga/

Research field (1)： Molecular biology

Research keywords (8)： Molecular Biology , DNA replication , replication origin , ORC , G-quadruplex , phase separation , Intrinsically disordered region , DNA/RNA binding

Research theme for competitive and other funds (17)：

2023 - 2024 複製開始タンパク質ORCのDNA認識機構の構造生物学的基盤
2022 - 2023 複製開始タンパク質ORCのDNA認識機構の構造生物学的基盤
2021 - 2022 ヒトORCのグアニン四重鎖結合と液液相分離の生理的意義
2021 - 2022 複製開始タンパク質ORCの構造とDNA結合に関する研究
2020 - 2021 ヒト複製開始タンパク質ORCのグアニン四重鎖DNA構造への結合に関する研究

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Papers (35)：

Afaf Eladl, Yudai Yamaoki, Keisuke Kamba, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Shou Waga, Takashi Nagata, Masato Katahira. NMR characterization of the structure of the intrinsically disordered region of human origin recognition complex subunit 1, hORC1, and of its interaction with G-quadruplex DNAs. Biochemical and Biophysical Research Communications. 2023
Aina Maria Mas, Enrique Goñi, Igor Ruiz de los Mozos, Aida Arcas, Luisa Statello, Jovanna González, Lorea Blázquez, Wei Ting Chelsea Lee, Dipika Gupta, Álvaro Sejas, et al. ORC1 binds to cis-transcribed RNAs for efficient activation of replication origins. Nature Communications. 2023. 14. 1
Afaf Eladl, Yudai Yamaoki, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Shou Waga, Takashi Nagata, Masato Katahira. Investigation of the Interaction of Human Origin Recognition Complex Subunit 1 with G-Quadruplex DNAs of Human c-myc Promoter and Telomere Regions. International Journal of Molecular Sciences. 2021. 22. 7. 3481-3481
Magda Budzowska, Thomas G. W. Graham, Alexandra Sobeck, Shou Waga, Johannes C. Walter. Regulation of the Rev1-pol zeta complex during bypass of a DNA interstrand cross-link. EMBO JOURNAL. 2015. 34. 14. 1971-1985
Shoko Hoshina, Kei Yura, Honami Teranishi, Noriko Kiyasu, Ayumi Tominaga, Haruka Kadoma, Ayaka Nakatsuka, Tomoko Kunichika, Chikashi Obuse, Shou Waga. Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA. Journal of Biological Chemistry. 2013. 288. 42. 30161-30171

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MISC (3)：

WAGA Shou, STILLMAN Bruce. Modulation of the Formation of a PCNA-RFC-DNA Complex by the CDK Inhibitor P21. 1998. 21. 359-359
WAGA Shou. Eukaryotic DNA replication: Analysis of reconstitution of SV40 DNA replication. 1995. 67. 9. 1142-1148
和賀祥. Cdkインヒビターp21とDNA複製, DNA修復. 実験医. 1995. 13. 1612-1617

Lectures and oral presentations (88)：

複製開始点結合タンパク質ORCのG4結合と核酸依存的相分離
(第39回染色体ワークショップ)
ヒトORCサブユニットのグアニン四重鎖結合ドメインの同定とその機能解析
(2021年度(第44回)日本分子生物学会年会)
ヒト複製開始タンパク質ORCとCDT1のDNA依存的な液-液相分離
(2021年度(第44回)日本分子生物学会年会)
ヒトORCの天然変性領域の機能に関する生化学的な解析
(2020年度(第43回)日本分子生物学会年会)
Investigation of the interaction between human origin recognition complex subunit 1 and G-rich DNAs

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Education (2)：

- 1991 Tohoku University Graduate School, Division of Agriculture Department of Agricultural Chemistry
- 1985 Tohoku University Faculty of Agriculture

Professional career (1)：

Doctor of Agriculture (Tohoku University)

Work history (6)：

2008 - 現在 Japan Women's University Faculty of Science
2002 - 2008 Osaka University Graduate School of Frontier Biosciences
1998 - 2002 Osaka University Research Institute for Microbial Diseases
1995 - 1998 Staff Investigator, Cold Spring Harbor Laboratory, USA
1991 - 1995 Postdotoral Fellow, Cold Spring Harbor Laboratory, USA

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Committee career (2)：

2021/04 - 現在 Director, JWU Research Center for Higher Education of Women, Japan Women's University
2018/04 - 2020/03 Dean of the Graduate School of Science, Japan Women's University

Association Membership(s) (3)：

Japanese Cancer Association , The Molecular Biology Society of Japan , The Japanese Biochemical Society

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