Rchr
J-GLOBAL ID:200901048160638568
Update date: Oct. 11, 2024 Michigami Toshimi
ミチガミ トシミ | Michigami Toshimi
Affiliation and department: Job title:
部長
Research field (3):
Metabolism and endocrinology
, Nephrology
, Physiology
Research keywords (5):
リン代謝
, カルシウム
, 骨代謝
, Calcium/Phosphate Metabolism
, Bone Metabolism
Research theme for competitive and other funds (23): - 2021 - 2024 Novel Molecular Mechanism for Hereditary Hypophosphatemia
- 2021 - 2024 骨細胞機能障害の解析と治療ターゲットの探索ー遺伝性骨疾患を対象としてー
- 2018 - 2021 Role of Osteocytes in Phosphate Sensing and Its Relation to Skeletal Maturation
- 2018 - 2021 Analysis of mechanism of bone fragility and effects of drugs in osteogenesis imperfecta using a graft model for enchondral bone formation
- 2017 - 2020 Local phosphorus production system in bone mineralization: role of alkaline phosphatase
- 2015 - 2018 Mechanism for phosphate homeostasis in fetus
- 2015 - 2018 Phosphate sensing and expression mechanism of genes responsible for hypophosphatemic rickets in osteocytes: Involvement of Pit1
- 2012 - 2015 Ozono Keiichi
- 2011 - 2013 リンの感知と骨ー腎機能的連関分子基盤の解析
- 2005 - 2011 Molecular Mechanisms Underlying Bone Development and Maintenance of Bone Mass
- 2008 - 2010 尿細管における細胞外無機リン酸シグナル応答性分子機構とFGF23感受性規定因子
- 2008 - 2010 Hepatocyte nuclear factor 4α promotes protein synthesis through the sodium-coupled neutral amino acid transporter 4 in liver development
- 2004 - 2010 Molecular Mechanisms Underlying Phosphate Homeostasis
- 2006 - 2007 Regulatory mechanism of the type XI collagen expression in osteoblasts
- 2006 - 2007 Functional Relationship between the Molecules Involved in the Renal Phosphate Reabsorption
- 2005 - 2006 Mechanisms of Growth Plate Regulation by Protein Tyrosine Phosphatase SHP-2
- 2004 - 2005 Molecular Mechanisms Underlying the Reabsorption of Inorganic Phosphate in Renal Tubules
- 2002 - 2003 Development of Organ-specific Treatment for Bone Metastasis in Neuroblastoma
- 2001 - 2002 Functional analysis of megalin, a key molecule of reabsorption in renal tubular cells ; making and using RAP-transgenic mice
- 2000 - 2001 動物モデルを用いた神経芽細胞腫骨転移メカニズムの解析
- 1999 - 2000 Characterization of the expression of 1 alpha-hydroxylase in kidney and application to renal failure
- 1998 - 1999 PTHrP産生腫瘍におけるビタミンD代謝異常および骨軟化症の病態解析-担癌ラットモデルを用いて
- 1997 - 1998 ビタミンD応答配列(VDRE)の解析 positive vs negative VDRE
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Papers (115): -
Toshimi Michigami, Hee Gyung Kang, Noriyuki Namba, Nobuaki Ito, Takuo Kubota, Ayumi Shintani, Daijiro Kabata, Masanori Kanematsu, Yayoi Nishida, Seiji Fukumoto, et al. Burosumab treatment of X-linked hypophosphatemia patients: interim analysis of the SUNFLOWER longitudinal, observational cohort study. JBMR plus. 2024. 8. 8. ziae079
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Keiichi Ozono, Takuo Kubota, Toshimi Michigami. Promising horizons in achondroplasia along with the development of new drugs. Endocrine journal. 2024. 71. 7. 643-650
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Hiroyuki Saitou, Taichi Kitaoka, Takuo Kubota, Junko Kanno, Hiroshi Mochizuki, Toshimi Michigami, Kosei Hasegawa, Ikuma Fujiwara, Takashi Hamajima, Daisuke Harada, et al. Clinical outcomes and medical management of achondroplasia in Japanese children: A retrospective medical record review of clinical data. American journal of medical genetics. Part A. 2024. 194. 8. e63612
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Natsumi Yamamura-Miyazaki, Toshimi Michigami, Keiichi Ozono, Katsusuke Yamamoto, Yukiko Hasuike. Factors associated with 1-year changes in serum fibroblast growth factor 23 levels in pediatric patients with chronic kidney disease. Clinical and experimental nephrology. 2022. 26. 10. 1014-1021
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Shinsuke Onuma, Saori Kinoshita, Shigeki Shimba, Keiichi Ozono, Toshimi Michigami, Masanobu Kawai. The Lack of Bmal1, a Core Clock Gene, in the Intestine Decreases Glucose Absorption in Mice. Endocrinology. 2022. 163. 9
more... MISC (35): -
Yasuhisa Ohata, Takuo Kubota, Shinji Takeyari, Taichi Kitaoka, Yukako Nakano, Kei Miyata, Chieko Yamada, Keiichi Ozono, Yasuki Ishihara, Hirofumi Nakayama, et al. Mutational analysis of the PHEX gene and genotype-phenotype correlation in 37 Japanese patients with X-linked hypophosphatemic rickets. JOURNAL OF BONE AND MINERAL RESEARCH. 2019. 34. 272-272
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向井 昌史, 山本 威久, 武鑓 真司, 大幡 泰久, 長谷川 泰浩, 北岡 太一, 窪田 拓生, 山本 勝輔, 溝口 好美, 道上 敏美, et al. ビタミンD欠乏性くる病による内反膝(O脚)の程度と関連する因子の検討. 日本内分泌学会雑誌. 2019. 95. 1. 467-467
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Yasuhisa Ohata, Shinji Takeyari, Taichi Kitaoka, Hirofumi Nakayama, Varoona Bizaoui, Yukako Nakano, Kenichi Yamamoto, Kei Miyata, Keiko Yamamoto, Takuo Kubota, et al. Comprehensive Genetic Analysis by Targeted Next Generation Sequencing and Genotype-phenotype Correlation of 47 Japanese Patients with Osteogenesis Imperfecta. JOURNAL OF BONE AND MINERAL RESEARCH. 2018. 33. 301-301
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Ryuichi Watanabe, Takeshi Miyamoto, Toshimi Michigami, Seiji Fukumoto, Masaya Nakamura, Morio Matsumoto. Enpp1 regulates Klotho expression under phosphate overload conditions. JOURNAL OF BONE AND MINERAL RESEARCH. 2017. 32. S325-S325
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窪田 拓生, 中山 尋文, 北中 幸子, 道上 敏美, 藤原 幾磨, 福本 誠二, 長谷川 高誠, 坂本 優子, 大薗 恵一. 本邦における小児ビタミンD欠乏症の発症率. 日本骨代謝学会学術集会プログラム抄録集. 2017. 35回. 165-165
more... Education (2): - - 1988 Osaka University Faculty of Medicine Medical School
- - 1988 Osaka University School of Medicine School of Medicine
Professional career (1): - Doctor(Medical Science) (Osaka University)
Work history (16): - 2003 - 現在 同上 部長
- 2003 - 現在 Chief, Department of Bone and Mineral Research
- 2002 - 現在 Osaka University Graduate School of Dentistry
- 1997 - 2003 Osaka Women's and Children's Hospital Research Institute
- 1997 - 2003 Senior Researcher, Department of
- 1995 - 1997 アメリカ合衆国テキサス大学サンアントニオ校内分泌
- 1995 - 1997 postdoctoral fellow, Division of
- 主任研究員
- 代謝部門 ポストドクロラルフェロー
- for Maternal & Child Health
- Osaka Medical Center and Research Institute
- Maternal & Child Health
- Center and Research Institute for
- Environmental Medicine, Osaka Medical
- Science Center at San Antonio
- Endocrinology, University of Texas Health
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Committee career (5): - - 現在 日本ステロイドホルモン学会 評議員
- - 現在 日本小児内分泌学会 評議員
- - 現在 日本内分泌学会 評議員
- - 現在 日本骨代謝学会 評議員
- 2002 - The Japanese Society for Bone and Mineral Metabolism Councilor
Awards (2): - 2013 - 日本骨代謝学会 学術賞
- 2012 - 日本小児内分泌学会 学術賞
Association Membership(s) (6):
アメリカ骨代謝学会
, 日本内分泌学会
, 日本骨代謝学会
, American Society for Bone and Mineral Research
, The Japan Endocrine Society
, The Japanese Society for Bone and Mineral Metabolism
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