Otani Kentaro

オオタニケンタロウ | Otani Kentaro

Affiliation and department：
Job title： Laboratory chief

Research field (2)： Cardiology , Medical systems

Research keywords (8)： Dilated cardiomyopathy , Peripartum cardiomyopathy , Natriuretic peptide , Mesenchymal stem cells , 再生医療 , 超音波医科学 , Regenerative Medicine , Ultrasound in Medicine

Research theme for competitive and other funds (15)：

2023 - 2026 MSC移植治療の機序解明:マクロファージのエフェロサイトーシス亢進と修復型転換
2021 - 2024 周産期心筋症の病態-遺伝要因・心筋炎症・血管障害-解明研究
2021 - 2024 Development of Anti-inflammation Regenerative Therapy for Acute Myocarditis Using Amnion-Derived Stromal Cells
2020 - 2023 心臓リモデリングにおける交感神経非依存的な新規の脳-心臓連環機構の解明
2018 - 2021 Biomarker study for early diagnosis of peripartum cardiomyopathy

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Papers (46)：

Kentaro Otani, Tsutomu Zeniya, Hidekazu Kawashima, Tetsuaki Moriguchi, Atsushi Nakano, Chunlei Han, Shunsuke Murata, Kunihiro Nishimura, Kazuhiro Koshino, Kenichi Yamahara, et al. Spatial and temporal tracking of multi-layered cells sheet using reporter gene imaging with human sodium iodide symporter: a preclinical study using a rat model of myocardial infarction. European journal of nuclear medicine and molecular imaging. 2024
Takeshi Tokudome, Kentaro Otani. Molecular Mechanism of Blood Pressure Regulation through the Atrial Natriuretic Peptide. Biology. 2022. 11. 9
Takeshi Tokudome, Kentaro Otani, Yuanjie Mao, Lars Jørn Jensen, Yuji Arai, Takahiro Miyazaki, Takashi Sonobe, James T. Pearson, Tsukasa Osaki, Naoto Minamino, et al. Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide. Hypertension. 2022. 79. 7. 1409-1422
大谷健太郎, 神谷千津子, 徳留健. 【ナトリウム利尿ペプチドに関する話題】妊娠中および産褥期における心臓ナトリウム利尿ペプチドの生理的意義の解明. 循環器内科. 2021. 89. 4. 386-394
Kentaro Otani, Takeshi Tokudome, Chizuko A Kamiya, Yuanjie Mao, Hirohito Nishimura, Takeshi Hasegawa, Yuji Arai, Mari Kaneko, Go Shioi, Junji Ishida, et al. Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart. Circulation. 2020. 141. 7. 571-588

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MISC (16)：

Kentaro Otani, Hirohito Nishimura, Atsunori Kamiya, Mariko Harada-Shiba. Ultrasound Molecular Imaging of Angiogenesis Using alphavbeta3 Integrin-targeted Bubbles Based on a Clinically Available Ultrasound Contrast Agent. CIRCULATION. 2017. 136
Kenichi Yamahara, Makiko Ohshima, Ken Ishikane, Kazuhiko Harada, Hidetoshi Tsuda, Kentaro Otani, Makoto Kodama, Kenji Kangawa, Tomoaki Ikeda. Systemic Administration of Allogenic Fetal Membrane-derived MSC Ameliorates Experimental Autoimmune Myocarditis via Suppression of Th1/Th17 Immunity. CIRCULATION. 2012. 126. 21
Development of Antibody-Carrying Microbubbles Based on Clinically Available Ultrasound Contrast Agent for Targeted Molecular Imaging: A Preliminary Chemical Study. Mol Imaging Biol. 2010
Kentaro Otani, Kenichi Yamahara, Shunsuke Ohnishi, Hiroaki Obata, Soichiro Kitamura, Noritoshi Nagaya. Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles. JOURNAL OF CONTROLLED RELEASE. 2009. 133. 2. 146-153
Kentaro Otani, Kenichi Yamahara, Shunsuke Ohnishi, Hiroaki Obata, Soichiro Kitamura, Noritoshi Nagaya. Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles. JOURNAL OF CONTROLLED RELEASE. 2009. 133. 2. 146-153

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Education (3)：

- 2006 Osaka University Graduate School of Medicine
- 2003 Osaka University Graduate School of Medicine
- 2001 Osaka University Faculty of Medicine

Professional career (2)：

修士(保健学) (大阪大学)
博士(保健学) (大阪大学)

Work history (5)：

2023/05 - 現在国立循環器病研究センター研究所分子薬理部研究室長
2022/05 - 現在 National Cerebral and Cardiovascular Center, Research Institute Center for Regenerative Medicine Laboratory chief
2011/04 - 現在国立循環器病研究センター研究所研究員
2008/04 - 2011/03 国立循環器病研究センター研究所流動研究員
2006/04 - 2008/03 ヒューマンサイエンス振興財団リサーチレジデント

Awards (8)：

2017/04 - 日本心筋症研究会第3回日本心筋症研究会 Young Investigator Award 優秀賞
2015/10 - 高血圧関連疾患モデル学会第51回高血圧関連疾患モデル学会ベストポスター賞
2014/02 - 日本心脈管作動物質学会第43回日本心脈管作動物質学会研究奨励賞(YIA)
2013/11 - 日本心血管内分泌代謝学会第17回日本心血管内分泌代謝学会若手研究奨励賞(YIA)
2012 - 日本心エコー図学会平成24年度海外学会発表優秀論文賞

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Association Membership(s) (4)：

American Heart Association , 日本心血管内分泌代謝学会 , The Japan Society of Ultrasonics in Medicine , The Japanese Circulation Society

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