Research keywords (1)：
In Vitro Fertilization and Genome editing
Research theme for competitive and other funds (19)：
2021 - 2026 Generation of African Swine Fever virus-resistant pigs by applying the concept of gene editing technology
2022 - 2025 Development of animal model for kidney-specific spontaneous tumours
2022 - 2025 Production of virus infection-resistant animals by a simple genome editing procedure
2022 - 2025 Production of virus infection-resistant animals by a simple genome editing procedure
2018 - 2021 Production of immunodeficient micro-mini pig using genome editing technology.
2017 - 2020 Production of genetically modified pigs by combined techniques of chromosome engineering and genome editing
2017 - 2019 Production of pigs for safe xenotransplantation by controlling infectious porcine endogenous retrovirus (PERV)
2015 - 2019 Study of sperm maturation factors on Asian Elephant
2014 - 2017 Evaluation of minor histocompatibility antigens by kidney transplant model derived from somatic cell cloned animals
2014 - 2017 Monitoring for multiple contamination of mycotoxins in feeding environment of cattle herds
2013 - 2017 Elucidation of male sterility occurred in cattle-yak hybrid and production of calf from the hybrid male in Mongolia
2012 - 2015 Study of non-coding RNA machinery complex-chromatoid body and dosage compensation.
2011 - 2015 Monitoring of naturally feed contamination of zearalenone in cattle herds and its preventive measures
2010 - 2012 Development of transgenic animals using a human artificial chromosome (HAC) vector
2008 - 2010 Monitoring of natural zearalenone contamination in feeds of cattle herds, with special focus on the effect on reproductive efficacy.
2006 - 2007 Monitoring of naturally contaminated zearalenone concentrations in feeding environment of cattles.especially the effects for reproductive efficacy
2004 - 2007 Production of prion gene-knockdown cattle by RNA interference(RNAi)technology
2000 - 2002 Production of human blood cohesion factor from bovine milk by nuclear transfer following the EGFP gene
1998 - 1999 Embryo transfer/In vitro fertilization of bovine and buffalo
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Papers (261)：
Nanaka Torigoe, Qingyi Lin, Bin Liu, Yuichiro Nakayama, Aya Nakai, Megumi Nagahara, Fuminori Tanihara, Maki Hirata, Takeshige Otoi. Effects of Electroporation Timing and Cumulus Cell Attachment on In Vitro Development and Genome Editing of Porcine Embryos. Reproduction in domestic animals = Zuchthygiene. 2025. 60. 2. e70011
Qingyi Lin, Koki Takebayashi, Nanaka Torigoe, Bin Liu, Zhao Namula, Maki Hirata, Fuminori Tanihara, Megumi Nagahara, Takeshige Otoi. Genome editing of porcine zygotes via lipofection of two guide RNAs using a CRISPR/Cas9 system. The Journal of reproduction and development. 2024. 70. 6. 356-361
Qingyi Lin, Nanaka Torigoe, Bin Liu, Yuichiro Nakayama, Aya Nakai, Zhao Namula, Megumi Nagahara, Fuminori Tanihara, Maki Hirata, Takeshige Otoi. Efficient gene editing of pig embryos by combining electroporation and lipofection. Veterinary world. 2024. 17. 11. 2701-2707
Koki Takebayashi, Manita Wittayarat, Maki Hirata, Qingyi Lin, Zhao Namula, Nanaka Torigoe, Bin Liu, Megumi Nagahara, Aya Nakai, Takeshige Otoi, et al. Optimization of embryonic stage for aggregation to generate chimeric pigs using gene-edited blastomeres. In vitro cellular & developmental biology. Animal. 2024
Thanh-Van Nguyen, Koki Takebayashi, Lanh Thi Kim Do, Zhao Namula, Manita Wittayarat, Megumi Nagahara, Maki Hirata, Takeshige Otoi, Fuminori Tanihara. Generation of allogenic chimera carrying mutations in PDX1 and TP53 genes via phytohemagglutinin-mediated blastomere aggregation in pigs. In vitro cellular & developmental biology. Animal. 2024. 60. 7. 708-715
佐藤陽子, 長原恵, 小笠原亮太, 大畠有貴, 川西君佳, 大畑遥, 柴田康暉, 杵淵茜, 東原由佳, 菅谷紀秀, et al. Study of male sterility and epididymal cell size in hybrids cattle-yak. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
- 1984 Yamaguchi University Graduate School, Division of Agriculture
- 1982 Yamaguchi University Faculty of Agriculture
Professional career (2)：
(BLANK) (Others)
(BLANK) (Yamaguchi University)
Work history (6)：
2021/04 - 現在 Bio-Innovation Research Center, Tokushima University Director
2016 - 現在 徳島大学 生物資源産業学部 教授
2015 - 2016 徳島大学 生物資源産業学部設置準備室 教授
2012 - 2015 Yamaguchi University Joint Faculty of Veterinary Medicine
2010 - 2012 YAMAGUCHI UNIVERSITY Faculty of Agriculture Professor
2006 - 2010 YAMAGUCHI UNIVERSITY United Graduate School of Veterinary Science,Yamaguchi University
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Awards (2)：
1997 - 徳島新聞賞 科学部門特別賞
1991 - 日本産業動物獣医学会 獣医学術奨励賞
Association Membership(s) (7)：
International Society for Transgenic Technologies
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, 国際胚移植学会
, Japan Embryo Transfer Society
, JAPAN SOCIETY FOR OVA RESEARCH
, SOCIETY FOR REPRODUCTION AND DEVELOPMENT
, THE JAPANESE SOCIETY OF VETERINARY SCIENCE
