Rchr

J-GLOBAL ID：200901049241691176 Update date: Sep. 03, 2024

Rikinari HANAYAMA,

ハナヤマリキナリ | Rikinari HANAYAMA,

Affiliation and department：
Other affiliations (1)：

Kanazawa University Graduate School of Medical Sciences

Homepage URL (2)： http://immunology.w3.kanazawa-u.ac.jp , http://immunology.w3.kanazawa-u.ac.jp/index2.html

Research field (3)： Medical biochemistry , Physiology , Immunology

Research keywords (5)： Exosome , Extracellular Vesicle , Immunoregulation , Neurodegeneration , Tumor Progression

Research theme for competitive and other funds (28)：

2024 - 2028 Elucidation of bio-regulatory mechanisms by brain-derived exosomes
2023 - 2027 Exosomes derived from intestinal bacteria and their prophylaxis in bronchial asthma caused by chemicals in the environment.
2024 - 2026 Development of designer exosomes that induce cancer antigen-specific cellular immunity
2023 - 2026 Innovative immunosuppression after organ transplantation using modified exosomes
2019 - 2026 WISE Program for Nano-Precision Medicine, Science, and Technology

2023 - 2025 Development of in vivo production technology of engineered exosomes inducing anti-tumor immunity

2022 - 2025 Establishment of a new biomarker using platelets for personalized treatment of pancreatic cancer

2018 - 2025 Elucidation and control of the interaction of biological responses by microparticles

2019 - 2024 Development of innovative immunoregulatory methods using designer exosomes

2019 - 2023 Exosomes and their miRNAs as central players in environmental chemical-induced bronchial asthma

2019 - 2023 Elucidation of the mechanism of hemophagocytosis by abnormal activation of macrophages

2019 - 2022 Elucidation of the function of exosomes in neural circuit reconstruction

2018 - 2021 Function of the macrophage lysosome-related molecule myoferlin in obesity-induced adipose inflammation.

2018 - 2021 Microenvironmental maintenance by exosome-mediated microglia from malignant glioma

2016 - 2019 Pathogenesis of exosome-mediated autoinflammation in the brain

2016 - 2019 Elucidation of the pathogenic mechanism of multiple system atrophy mediated by neuronal exosomes

2016 - 2018 Elucidation of the pathology caused by melting of others and development of visualization technology using MRI

2014 - 2017 Identification of novel tumor markers by high-purity exosome purification method

2013 - 2017 Physiological functions of secretory membrane vesicle exosomes and their target cells

2014 - 2016 Role of neuronal exosomes in Parkinson's disease

2012 - 2016 Mechanism of lysosomal exocytosis by inflammatory macrophages

2012 - 2015 Development of Novel Antiviral Drugs and Vaccines Targeting the Lipid Bilayer of Hepatitis Viruses

2011 - 2015 Private Research Grants

2011 - 2014 Molecular mechanisms of axon pruning by glial cells

2012 - 2014 Maintenance mechanism of brain environment via phagocytosis by glial cells and its disruption

2010 - 2013 Elucidation of the operating principle of phagocytosis of apoptotic cells

2005 - 2008 Role of myocyte enhancer factor 2 in synapse development

2002 - 2004 Molecular mechanism of apoptotic cell recognition and phagocytosis by macrophages

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Papers (60)：

Yifan Li, Kouyuki Hirayasu, Gen Hasegawa, Yosei Tomita, Yuko Hashikawa, Ryosuke Hiwa, Jiaqi Wang, Atsushi Furukawa, Ryosuke Hiwa, Hisashi Arase, et al. Fibrinogen induces inflammatory responses via the immune activating receptor LILRA2. Frontiers in Immunology. in press. 2024
Kyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita, Tadashi Yamamuro, Kohei Nishino, Shuhei Nakamura, Hiroko Omori, Tatsuya Kaminishi, Satoshi Oikawa, et al. The Rubicon-WIPI axis regulates exosome biogenesis during ageing. Nature Cell Biology. 2024
Yoshitaka Zaimoku, Kazuya Sakai, Noriaki Tsuji, Kazuyoshi Hosomichi, Shinya Yamada, Dung Cao Tran, Miku Kobayashi, Ayana Sugiyama, Kouyuki Hirayasu, Hiroki Mizumaki, et al. Haematopoietic regeneration by HLA-A*0206-deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment. British Journal of Haematology. 2024
Yoshinobu Takakura, Rikinari Hanayama, Kazunari Akiyoshi, Shiroh Futaki, Kyoko Hida, Takanori Ichiki, Akiko Ishii-Watabe, Masahiko Kuroda, Kazushige Maki, Yasuo Miura, et al. Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles. Pharmaceutical Research. 2024
Arisa Hori, Saori Toyoura, Miyu Fujiwara, Ren Taniguchi, Yasutaka Kano, Tomoyoshi Yamano, Rikinari Hanayama, Masafumi Nakayama. MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C. iScience. 2024. 27. 5. 109704-109704

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MISC (21)：

Yoshihiro Araki, Hiroyuki Tsuchiya, Rikinari Hanayama. Potential clinical applications of microRNAs derived from osteosarcoma cells. Precision Medicine. 2024. 7. 4. 71-76
Kenji Goto, Takeshi Yoshida, Yayoi Inomata, Rikinari Hanayama, Akifumi Seto. Elucidation of biological responses to atmospheric particulates. Seikagaku. 2023. 95. 2. 151-156
Tomoyoshi Yamano, Rikinari Hanayama. Roles of Aire in T-cell peripheral immune tolerance. Clinical Immunology and Allergology. 2022. 58. 3. 19-24
Hironori Kawahara, Yasutake Tada, Rikinari Hanayama. Explanation about exosome. Clinical Neuroscience. 2022. 40. 7. 830-833
Rikinari Hanayama. EV research at fever pitch. Experimental Medicine. 2021. 39. 20. 2-8

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Patents (8)：

Compositions for regulating CAR-T cell activation, hematopoietic stem cell proliferation, and iPS cell differentiation, and use thereof
Immunoregulatory method, nucleic acid for immunoregulation and use thereof 2
Immunoregulatory method, nucleic acid for immunoregulation and use thereof 1
Antigen-presenting extracellular vesicles
Prognostic or assisted prognostic methods for bone tumors

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Books (12)：

Experimental Medicine: Neurodegenerative diseases
Yodosha 2023
Experimental Medicine: New Macrophage
Yodosha 2022
Experimental Medicine: Biology of EVs
Yodosha 2021
Experimental Medicine: New Generation Flow Cytometry
Yodosha 2021
JB Special Issue-Medical chemistry of extracellular vesicles
Oxford Academic 2021

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Lectures and oral presentations (122)：

Keynote Lecture, The 43rd Annual Meeting of the Japanese Society of Aesthetic Dermatology
(Osaka 2025)
17th European meeting on glial cells in health and disease
(Marseille, France 2025)
41th Annual Meeting of the Japanese Society of Toxicologic Pathology
(Mishima 2025)
Kanazawa University Industry-Academia Collaboration Symposium
(Tokyo 2024)
65th Annual Meeting of Japan Society for Atmospheric Environment
(Hiyoshi 2024)

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Education (3)：

2000 - 2004 Ph.D, Osaka University (Advisor: Prof. Shigekazu Nagata)
1993 - 1999 MD, Osaka University
1990 - 1993 Takatsuki High School

Professional career (1)：

MD, PhD (Osaka University)

Work history (12)：

2019 - 現在 Coordinator, WISE Program for Nano-Precision Medicine, Science, and Technology, Kanazawa University
2018 - 現在 JST CREST Investigator
2017 - 現在 Professor, WPI Nano Life Science Institute, Kanazawa University
2015 - 現在 Professor, Department of Immunology, Graduate School of Medical Sciences, Kanazawa University
2015 - 2017 Program Officer, KAKENHI, MEXT

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Committee career (12)：

2023 - 現在 Acting Member, Research Funding Subcommittee, Council for Science and Technology, MEXT
2020 - 現在 JST FOREST Program Director Committee Member
2019 - 現在 Advisor, FUJIFILM Wako
2019 - 現在 Councilor, The Japanese Society for Immunology
2019 - 現在 Councilor, The Japanese Biochemical Society

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Awards (10)：

2021 - JB Reviewer Award
2019 - Kanazawa University Meritorious Award
2014 - Osaka University President's Commendation
2013 - Osaka University President's Award
2012 - Astellas Biomedical Award

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Association Membership(s) (5)：

International Society for Extracellular Vesicles , Japanese Society for Extracellular Vesicles , The Japanese Society of Drug Delivery System , The Japanese Society for Immunology , The Japanese Biochemical Society

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