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J-GLOBAL ID：200901049241691176 Update date: Apr. 09, 2025

Rikinari HANAYAMA,

ハナヤマリキナリ | Rikinari HANAYAMA,

Affiliation and department：
Other affiliations (1)：

Kanazawa University Graduate School of Medical Sciences

Homepage URL (2)： http://immunology.w3.kanazawa-u.ac.jp , http://immunology.w3.kanazawa-u.ac.jp/index2.html

Research field (3)： Medical biochemistry , Physiology , Immunology

Research keywords (5)： Exosome , Extracellular Vesicle , Immunoregulation , Neurodegeneration , Tumor Progression

Research theme for competitive and other funds (30)：

2024 - 2029 Development of active targeting methods using designer exosomes
2024 - 2028 Elucidation of bio-regulatory mechanisms by brain-derived exosomes
2024 - 2027 Establishment of mass production and quality control technology for high quality exosome formulations
2023 - 2027 Exosomes derived from intestinal bacteria and their prophylaxis in bronchial asthma caused by chemicals in the environment.
2024 - 2026 Development of designer exosomes that induce cancer antigen-specific cellular immunity

2023 - 2026 Innovative immunosuppression after organ transplantation using modified exosomes

2019 - 2026 WISE Program for Nano-Precision Medicine, Science, and Technology

2023 - 2025 Development of in vivo production technology of engineered exosomes inducing anti-tumor immunity

2022 - 2025 Establishment of a new biomarker using platelets for personalized treatment of pancreatic cancer

2018 - 2025 Elucidation and control of the interaction of biological responses by microparticles

2019 - 2024 Development of innovative immunoregulatory methods using designer exosomes

2019 - 2023 Exosomes and their miRNAs as central players in environmental chemical-induced bronchial asthma

2019 - 2023 Elucidation of the mechanism of hemophagocytosis by abnormal activation of macrophages

2019 - 2022 Elucidation of the function of exosomes in neural circuit reconstruction

2018 - 2021 Function of the macrophage lysosome-related molecule myoferlin in obesity-induced adipose inflammation.

2018 - 2021 Microenvironmental maintenance by exosome-mediated microglia from malignant glioma

2016 - 2019 Pathogenesis of exosome-mediated autoinflammation in the brain

2016 - 2019 Elucidation of the pathogenic mechanism of multiple system atrophy mediated by neuronal exosomes

2016 - 2018 Elucidation of the pathology caused by melting of others and development of visualization technology using MRI

2014 - 2017 Identification of novel tumor markers by high-purity exosome purification method

2013 - 2017 Physiological functions of secretory membrane vesicle exosomes and their target cells

2014 - 2016 Role of neuronal exosomes in Parkinson's disease

2012 - 2016 Mechanism of lysosomal exocytosis by inflammatory macrophages

2012 - 2015 Development of Novel Antiviral Drugs and Vaccines Targeting the Lipid Bilayer of Hepatitis Viruses

2011 - 2015 Private Research Grants

2011 - 2014 Molecular mechanisms of axon pruning by glial cells

2012 - 2014 Maintenance mechanism of brain environment via phagocytosis by glial cells and its disruption

2010 - 2013 Elucidation of the operating principle of phagocytosis of apoptotic cells

2005 - 2008 Role of myocyte enhancer factor 2 in synapse development

2002 - 2004 Molecular mechanism of apoptotic cell recognition and phagocytosis by macrophages

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Papers (63)：

Xiabing Lyu, Tomoyoshi Yamano, Kanto Nagamori, Shota Imai, Toan Van Le, Dilireba Bolidong, Makie Ueda, Shota Warashina, Hidefumi Mukai, Seigo Hayashi, et al. Direct delivery of immune modulators to tumour-infiltrating lymphocytes using engineered extracellular vesicles. Journal of Extracellular Vesicles. 2025. 14. 4. e70035
Muhammad Isman Sandira, Keesiang Lim, Takeshi Yoshida, Elma Sakinatus Sajidah, Shinnosuke Narimatsu, Reon Imakawa, Kota Yoshimura, Goro Nishide, Yujia Qiu, Azuma Taoka, et al. Nanoscopic Profiling of Small Extracellular Vesicles via High-Speed Atomic Force Microscopy (HS-AFM) Videography. Journal of Extracellular Vesicles. 2025. 14. 4. e270050
Hiroki Ida, Takeshi Yoshida, Akichika Kumatani, Rikinari Hanayama, Yasufumi Takahashi. Direct Extraction and Evaluation of Intraluminal Vesicles Inside a Single Cell. Nano Letters. 2025. 25. 11. 4322-4329
Hironori Kawahara, Rikinari Hanayama. Neurodegenerative disorder and fine particululate matter. Extracellular Fine Particles. 2025. 185-196
Yoshitaka Zaimoku, Kazuya Sakai, Noriaki Tsuji, Kazuyoshi Hosomichi, Shinya Yamada, Dung Cao Tran, Miku Kobayashi, Ayana Sugiyama, Kouyuki Hirayasu, Hiroki Mizumaki, et al. Haematopoietic regeneration by HLA-A*0206-deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment. British Journal of Haematology. 2024. 205. 5. 1995-1999

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MISC (24)：

Rikinari Hanayama, Takafumi Seto. Elucidation and Regulation of Biological Responses by Fine Particles. Journal of Japanese Society for Atmospheric Enivronment. 2025. 60. 1
Shota Imai, Tomoyoshi Yamano, Rikinari Hanayama. Immunoregulation by extracellular vesicles (Japanese). Journal of Clinical and Experimental Medicine. 2024. 291. 9. 668-672
Xiabing Lyu, Tomoyoshi Yamano, Rikinari Hanayama. Exosome-based Nucleic Acid Therapeutics (Japanese). Drug Delivery System. 2024. 39. 5. 346-353
Yoshihiro Araki, Hiroyuki Tsuchiya, Rikinari Hanayama. Potential clinical applications of microRNAs derived from osteosarcoma cells. (Japanese). Precision Medicine. 2024. 7. 4. 71-76
Kenji Goto, Takeshi Yoshida, Yayoi Inomata, Rikinari Hanayama, Akifumi Seto. Elucidation of biological responses to atmospheric particulates (Japanese). Seikagaku. 2023. 95. 2. 151-156

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Patents (8)：

Compounds for promoting the secretion of extracellular vesicles
Compositions for regulating CAR-T cell activation, hematopoietic stem cell proliferation, and iPS cell differentiation, and use thereof
Immunoregulatory method, nucleic acid for immunoregulation and use thereof 2
Immunoregulatory method, nucleic acid for immunoregulation and use thereof 1
Antigen-presenting extracellular vesicles

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Books (13)：

Extracellular Fine Particles
Springer 2025
Experimental Medicine: Neurodegenerative diseases
Yodosha 2023
Experimental Medicine: New Macrophage
Yodosha 2022
Experimental Medicine: Biology of EVs
Yodosha 2021
Experimental Medicine: New Generation Flow Cytometry
Yodosha 2021

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Lectures and oral presentations (127)：

Special Lecture, 10th Lung Cancer Bio-conference
(Tokyo 2025)
Senri Life Science Seminar
(Osaka 2025)
Keynote Lecture, The 43rd Annual Meeting of the Japanese Society of Aesthetic Dermatology
(Osaka 2025)
Special Symposium, The 41st Annual Meeting of the Japanese Society of DDS
(Chiba 2025)
TeSH Platform Community Event
(Tokyo 2025)

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Education (3)：

2000 - 2004 Ph.D, Osaka University (Advisor: Prof. Shigekazu Nagata)
1993 - 1999 MD, Osaka University
1990 - 1993 Takatsuki High School

Professional career (1)：

MD, PhD (Osaka University)

Work history (12)：

2019 - 現在 Coordinator, WISE Program for Nano-Precision Medicine, Science, and Technology, Kanazawa University
2017 - 現在 Professor, WPI Nano Life Science Institute, Kanazawa University
2015 - 現在 Professor, Department of Immunology, Graduate School of Medical Sciences, Kanazawa University
2018 - 2025 JST CREST Investigator
2015 - 2017 Program Officer, KAKENHI, MEXT

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Committee career (13)：

2024 - 現在 Advisor, Q-LEAP Quantum Life Science Project
2023 - 現在 Acting Member, Research Funding Subcommittee, Council for Science and Technology, MEXT
2020 - 現在 JST FOREST Program Director Committee Member
2019 - 現在 Advisor, FUJIFILM Wako
2019 - 現在 Councilor, The Japanese Society for Immunology

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Awards (10)：

2021 - JB Reviewer Award
2019 - Kanazawa University Meritorious Award
2014 - Osaka University President's Commendation
2013 - Osaka University President's Award
2012 - Astellas Biomedical Award

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Association Membership(s) (5)：

International Society for Extracellular Vesicles , Japanese Society for Extracellular Vesicles , The Japanese Society of Drug Delivery System , The Japanese Society for Immunology , The Japanese Biochemical Society

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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