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J-GLOBAL ID：200901050334426802 Update date: Apr. 06, 2025

Funatsu Takashi

フナツタカシ | Funatsu Takashi

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Affiliation and department：
Job title： Professor (Special Appoinntment), Dean
Other affiliations (1)：

The University of Tokyo

Research field (4)： Pharmaceuticals - analytical and physicochemistry , Biophysics , Nano/micro-systems , Nanomaterials

Research keywords (5)： Bioimaging , Single molecule measurement and manipulation , Analytical Chemistry , 1分子生物物理学 , Single-molecule Biophysics

Research theme for competitive and other funds (45)：

2021 - 2024 白血病単一細胞分岐鎖アミノ酸代謝特性解析のためのマイクロ分離分析法の開発
2018 - 2022 Elucidation of molecular mechanism of translational control by RNA-protein complexes in living cells
2018 - 2020 Temperature measurement of specific biomolecules in intracellular nanospace
2017 - 2019 Elucidation of translational arrest mechanism of SecM and TnaC by single molecule measurement
2016 - 2018 Development of super-resolution real-time molecular imaging technique in the deep part of the body

2016 - 2018 Measure the temperature of specific biomolecules in cells

2015 - 2018 Elucidation of translational regulatory mechanism by RNA-protein complex

2015 - 2017 1分子計測によるSecMの翻訳アレスト機構の解明

2011 - 2016 Advanced Micro Fluidic Engineering and Its Applications for High Sensitive Quantitative Measurements of Biomolecules

2013 - 2015 Manipulating illumination and imaging systems of an optical microscope using a spatial light modulator

2012 - 2015 Single-molecule analysis of functions of biomolecules by linear zero-mode waveguides

2009 - 2014 Development of super-resolution fluorescence microscopy and single-molecule analysis of signal transduction mechanism of a receptor protein in cell membrane

2009 - 2014 Integrative understanding of biological processes mediated by transient macromolecul ar complexes; New technology for visualizing physiologically metastable states

2011 - 2013 Imaging of mRNA in living cells using antisense probe

2009 - 2011 Single-molecule analysis of functions of biomolecular machines that synthesize or assist folding of proteins.

2007 - 2010 Development of Micro Fluidic Systems for Real Time Function Analysis of Single Biomolecules

2008 - 2009 タンパク質の誕生と折りたたみの1分子解析

2005 - 2008 Analyses of functions and interactions of biomolecules by microand nano-devices

2006 - 2007 表面増強共鳴ラマン散乱法を用いたタンパク質の構造と機能の1分子解析

2005 - 2006 Development of microchip liquid chromatography for ultra-sensitive analysis of trace amounts of bio-molecules.

2004 - 2006 Development of Biological Sample Separation/Extraction and Preparation Microsystems for High Performance Biosensing

2002 - 2006 The Single Molecular Design and Systemic Assembly of Protein Function

2001 - 2005 ナノ構造配列を基盤とする分子ナノ工学の構築とマイクロシステムへの展開

2002 - 2004 Molecular mechanism of chaperonin-assisted protein folding studied by single molecule imaging.

2003 - 2003 1分子蛍光イメージング法による分子シャペロニンの蛋白質折れたたみ機構解析

2003 - 2003 1分子蛍光イメージング法によるmRNAのプロセシングと核外輸送の解析

2001 - 2003 Production of novel proteins using the micro system that permits sorting and functional evaluation at single molecular level

2001 - 2003 Analysis and control of the fluids, interfaces of liquid-liquid and liquid-solid in microchannels

1999 - 2003 DNA・タンパク質相互作用の1分子イメージングと計測

2002 - 2002 1分子蛍光イメージング法による分子シャペロニンの蛋白質折れたたみ機構解析

2002 - 2002 1分子蛍光イメージング法によるmRNA核外輸送メカニズムの解析

2000 - 2002 Studies on sorting and fixing of. Bioiooiecules for high performance micro chemical/biochemical analysis systems

2000 - 2001 マイクロシステムによる1分子・オルガネラソーターと1分子機能アッセイ系の開発

1999 - 2001 Single-molecule imaging of processing and transport of mRNA within a living cell

1998 - 2001 Microscopic imaging and analysis of single molecular function and inter molecular synchronization in Super molecular system

1997 - 2001 Dynamic interaction between chaperone and its substrates

2000 - 2000 モデル真核単細胞生物による細胞運動機構研究の現状と展望

1998 - 2000 Development of Fluorescence Microscopy for Visualizing Single Biomolecules in Living Cells

1998 - 1999 繰り返し凍結、解凍が可能なクライオ光学顕微鏡の開発

1998 - 1998 1分子蛍光イメージング法による生物分子モーターの連続歩行性能とステップの解析

1998 - 1998 1分子蛍光イメージング法を用いた分子シャペロンによる蛋白質折れたたみ機構の解析

1990 - 1991 A New Rapid Freezing Apparatus for Electron Microscopy

1989 - 1990 選択的構造解体法と急速凍結法による細胞骨格の構造・機能解析

1988 - 1988 細いフィラメントを再構成した骨格筋線維系の確立とその収縮特性の検討

1987 - 1987 筋線維内弾性系の構造解析-アクチン線維切断タンパク質ブレビンを道具として-

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Papers (200)：

Mai Yamagishi, Yutaka Hori, Nobutake Suzuki, Yu Peng, Yoshie Harada, Takashi Funatsu, Osamu Ohara, Yoshitaka Shirasaki. Evaluation of the microenvironment formed by interferon-β. Frontiers in Chemical Biology. 2025. 3
Atsushi Minami, Takehito Tanzawa, Zhuohao Yang, Takashi Funatsu, Tomohisa Kuzuyama, Hideji Yoshida, Takayuki Kato, Tetsuhiro Ogawa. ‘Tuning’ of ribosome levels mediated by RNase I and hibernating ribosomes. 2024
Ko Sugawara, Shin-nosuke Uno, Mako Kamiya, Akihiko Sakamoto, Yasuteru Urano, Takashi Funatsu, Kohki Okabe. Nanoscale dynamics and localization of single endogenous mRNAs in stress granules. Nucleic Acids Research. 2024
Mai Yamagishi, Kaede Miyata, Takashi Kamatani, Hiroki Kabata, Rie Baba, Yumiko Tanaka, Nobutake Suzuki, Masako Matsusaka, Yasutaka Motomura, Tsuyoshi Kiniwa, et al. Quantitative live-cell imaging of secretion activity reveals dynamic immune responses. iScience. 2024. 27. 6. 109840-109840
Muneki Isokawa, Kanki Nakanishi, Takahiro Kanamori, Tetsushi Sekiguchi, Takashi Funatsu, Shuichi Shoji, Makoto Tsunoda. Pillar Array Mixer for Postcolumn Derivatization Integrated into Liquid Chromatography-Based Microfluidic Device. Analytical chemistry. 2024

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MISC (199)：

村上光, 佐藤佑, 岡部弘基, 船津高志. 哺乳動物細胞に見出されたコレステロール依存的な熱吸収機構. 脂質生化学研究. 2022. 64. 192-194
大多和拓磨, 船津高志, 角田誠. 2-ヒドロキシグルタル酸とその環状化合物の光学異性体分析法の開発. 日本薬学会年会要旨集. 2022. 142年会. 26M-pm11S
牟田幹悠, 斉藤開, 飯塚怜, 川久保渉, 尹棟鉉, 関口哲志, 庄子習一, 伊藤芽, 秦田勇二, 船津高志. 液滴変形能を利用したソーティングデバイスによる環境中アガラーゼ産生菌の単一細菌スクリーニング. 応用糖質科学. 2022. 12. 3
村上光, 佐藤佑, 岡部弘基, 船津高志. 培養細胞を用いた生物種に固有な熱力学的特性の解析. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-452]
山根大典, 寳田雅治, 岡部弘基, 須藤優喜, 船津高志, 富田泰輔. 細胞内温度勾配によるTDP-43凝縮体形成機構の解析. Dementia Japan. 2021. 35. 4. 654-654

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Education (3)：

1984 - 1987 Waseda University Graduate School of Science and Engineering Department of Pure and Applied Physics, Doctoral course (coursework completed without degree)
1982 - 1984 Waseda University Graduate School of Science and Engineering Department of Pure and Applied Physics, Master's course
1978 - 1982 Waseda University School of Science and Engineering Department of Physics

Professional career (1)：

Doctor of Science (Waseda University)

Work history (10)：

2025/04 - 現在 Hiroshima University Graduate School of Integrate Sciences for Life Professor (Special Appoinntment), Dean
2024/04 - 2025/03 Live Cell Diagnosis, Ltd. Research and Development Department Fellow
2004/03 - 2024/03 The University of Tokyo Graduate School of Pharmaceutical Sciences Professor
2002/10 - 2004/02 Waseda University School of Science and Engineering, Department of Physics
1997/10 - 2002/09 Waseda University School of Science and Engineering, Department of Physics

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Association Membership(s) (4)：

The Japan Society for Analytical Chemistry , BIOIMAGING SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN , The Biophysical Society of Japan

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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