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J-GLOBAL ID：200901051579267536 Update date: Mar. 05, 2025

Shin Hye-Won

シンヘウォン | Shin Hye-Won

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Affiliation and department：
Homepage URL (1)： http://www.pharm.kyoto-u.ac.jp/hshin/ShinIndex.html

Research field (1)： Cell biology

Research theme for competitive and other funds (12)：

2019 - 2024 Relationship between architecture and function of intraciliary protein trafficking complex: molecular basis for ciliopathies
2020 - 2023 Physiological roles of lipid asymmetry in biological membranes mediated by lipid flippases
2017 - 2020 Regulation of enzymatic activities of P4-ATPases and its physiological function
2016 - 2018 P4-ATPase-mediated dynamic ordering of phospholipids in biological membranes
2015 - 2017 膜運動におけるリン脂質の量的・質的変化の作用機序

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Papers (74)：

Koshi Tasaki, Yuuki Satoda, Shuhei Chiba, Hye-Won Shin, Yohei Katoh, Kazuhisa Nakayama. Mutually independent and cilia-independent assembly of IFT-A and IFT-B complexes at mother centriole. Molecular Biology of the Cell. 2025
Yuto Takahashi, Yamato Ishida, Saishu Yoshida, Hye-Won Shin, Yohei Katoh, Kazuhisa Nakayama. Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression. Journal of Cell Science. 2025
Hye-Won Shin, Hiroyuki Takatsu. Substrates, regulation, cellular functions, and disease associations of P4-ATPases. Communications Biology. 2025
Shingo Yamazaki, Taiju Fujii, Shuhei Chiba, Hye-Won Shin, Kazuhisa Nakayama, Yohei Katoh. TXNDC15, an ER-localized thioredoxin-like transmembrane protein, contributes to ciliary transition zone integrity. Journal of Cell Science. 2024
Tsukasa Yagi, Riki Nakabuchi, Yumeka Muranaka, Gaku Tanaka, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin. Lipid flippases ATP9A and ATP9B form a complex and contribute to the secretory pathway from the Golgi apparatus. 2024

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MISC (15)：

Hye-Won Shin, Hiroyuki Takatsu. Regulation mechanism of phosphatidylserine-flippase at the plasma membrane. Seikagaku. 2018. 90. 4. 486-490
Hye-Won Shin. Membrane curvature generation by transbilayer lipid flip-flop. 2018. 36. 13. 2239-2242
Hye-Won Shin, Zhiqiu Man, Kazuhisa Nakayama. Roles of small GTPases and BAR domain proteins in post-Golgi membrane traffic. Seikagaku. 2012. 84. 9. 785-790
Hye-Won Shin. [Roles of the Arf family of small GTPases in membrane traffic]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 2008. 53. 16Suppl. 2058-2064
申惠媛, 中山和久. ARFによるメンブレントラフィックの調節 (特集メンブレントラフィック研究の新局面--いま明かされる細胞内輸送の仕組み). 細胞工学. 2006. 25. 11. 1253-1257

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Books (4)：

レーニンジャ-新生化学:生化学と分子生物学の基本原理(第7版)
廣川書店 2019
Dojin BioScience Series 24 メンブレントラフィック
化学同人 2016
レーニンジャ-新生化学:生化学と分子生物学の基本原理(第6版)
廣川書店 2015
プロッパー細胞生物学:細胞の基本原理を学ぶ(第1版)
化学同人 2013

Lectures and oral presentations (157)：

膜脂質flippase ATP9A/ATP9Bのメンブレントラフィックにおける機能
(第76回日本細胞生物学会大会 2024)
ホスファチジルコリンフリッパーゼATP8B2の知的障害患者由来de novo変異体に関する研究
(第96回日本生化学会大会 2023)
新奇ホスファチジルイノシトール-flippaseの同定とその細胞内機能
(第96回日本生化学会大会 2023)
ゴルジ体以降のタンパク質輸送経路における脂質フリッパーゼATP9A/ATP9Bの機能解析
(第96回日本生化学会大会 2023)
糖脂質フリッパーゼによる細胞内グルコシルセラミド代謝調節
(第96回日本生化学会大会 2023)

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Association Membership(s) (6)：

Korean Society for Molecular and Cellular Biology , American Society for Biochemistry and Molecular Biology , The American Society for Cell Biology , 日本薬学会 , 日本生化学会 , 日本細胞生物学会

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