Shin Hye-Won

シンヘウォン | Shin Hye-Won

Affiliation and department：
Homepage URL (1)： http://www.pharm.kyoto-u.ac.jp/hshin/ShinIndex.html

Research field (1)： Cell biology

Research theme for competitive and other funds (12)：

2019 - 2024 Relationship between architecture and function of intraciliary protein trafficking complex: molecular basis for ciliopathies
2020 - 2023 Physiological roles of lipid asymmetry in biological membranes mediated by lipid flippases
2017 - 2020 Regulation of enzymatic activities of P4-ATPases and its physiological function
2016 - 2018 P4-ATPase-mediated dynamic ordering of phospholipids in biological membranes
2015 - 2017 膜運動におけるリン脂質の量的・質的変化の作用機序

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Papers (70)：

Tsukasa Yagi, Riki Nakabuchi, Yumeka Muranaka, Gaku Tanaka, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin. Lipid flippases ATP9A and ATP9B form a complex and contribute to the secretory pathway from the Golgi apparatus. 2024
Yumeka Muranaka, Ryo Shigetomi, Yugo Iwasaki, Asuka Hamamoto, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin. Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane. Biochemical Journal. 2024. 481. 1187-1202
Hiroyuki Takatsu, Narumi Nishimura, Yusuke Kosugi, Haruo Ogawa, Kazuhisa Nakayama, Estelle Colin, Konrad Platzer, Rami Abou Jamra, Silke Redler, Clément Prouteau, et al. De Novo Missense Variations of ATP8B2 Impair Its Phosphatidylcholine Flippase Activity. Molecular and Cellular Biology. 2024. 1-16
Natsuki Kita, Asuka Hamamoto, Siddabasave Gowda B. Gowda, Hiroyuki Takatsu, Kazuhisa Nakayama, Makoto Arita, Shu-Ping Hui, Hye-Won Shin. Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis. Journal of Lipid Research. 2024
Punith M. Sundaraswamy, Yusuke Minami, Jayashankar Jayaprakash, Siddabasave Gowda B. Gowda, Hiroyuki Takatsu, Divyavani Gowda, Hye-Won Shin, Shu-Ping Hui. A facile method for monitoring sphingomyelin synthase activity in HeLa cells using liquid chromatography/mass spectrometry. The Analyst. 2024. 149. 3293-3301

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MISC (15)：

Hye-Won Shin, Hiroyuki Takatsu. Regulation mechanism of phosphatidylserine-flippase at the plasma membrane. Seikagaku. 2018. 90. 4. 486-490
Hye-Won Shin. Membrane curvature generation by transbilayer lipid flip-flop. 2018. 36. 13. 2239-2242
Hye-Won Shin, Zhiqiu Man, Kazuhisa Nakayama. Roles of small GTPases and BAR domain proteins in post-Golgi membrane traffic. Seikagaku. 2012. 84. 9. 785-790
Hye-Won Shin. [Roles of the Arf family of small GTPases in membrane traffic]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 2008. 53. 16Suppl. 2058-2064
申惠媛, 中山和久. ARFによるメンブレントラフィックの調節 (特集メンブレントラフィック研究の新局面--いま明かされる細胞内輸送の仕組み). 細胞工学. 2006. 25. 11. 1253-1257

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Books (4)：

レーニンジャ-新生化学:生化学と分子生物学の基本原理(第7版)
廣川書店 2019
Dojin BioScience Series 24 メンブレントラフィック
化学同人 2016
レーニンジャ-新生化学:生化学と分子生物学の基本原理(第6版)
廣川書店 2015
プロッパー細胞生物学:細胞の基本原理を学ぶ(第1版)
化学同人 2013

Lectures and oral presentations (157)：

膜脂質flippase ATP9A/ATP9Bのメンブレントラフィックにおける機能
(第76回日本細胞生物学会大会 2024)
ホスファチジルコリンフリッパーゼATP8B2の知的障害患者由来de novo変異体に関する研究
(第96回日本生化学会大会 2023)
新奇ホスファチジルイノシトール-flippaseの同定とその細胞内機能
(第96回日本生化学会大会 2023)
ゴルジ体以降のタンパク質輸送経路における脂質フリッパーゼATP9A/ATP9Bの機能解析
(第96回日本生化学会大会 2023)
糖脂質フリッパーゼによる細胞内グルコシルセラミド代謝調節
(第96回日本生化学会大会 2023)

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Association Membership(s) (6)：

Korean Society for Molecular and Cellular Biology , American Society for Biochemistry and Molecular Biology , The American Society for Cell Biology , 日本薬学会 , 日本生化学会 , 日本細胞生物学会

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