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J-GLOBAL ID：200901053148042823 Update date: Feb. 03, 2025

Aoki Shunji

Research field (1)： Molecular biochemistry

Research keywords (2)：天然薬物学 , Biological Organic Chemistry

Research theme for competitive and other funds (2)：

1998 - 海洋天然物の生物有機化学的研究
The Biological Organic chemistry of marine natural products

Papers (29)：

Syuhei Nakao, Miyuki Mabuchi, Tadashi Shimizu, Yoshihiro Itoh, Yuko Takeuchi, Masahiro Ueda, Hiroaki Mizuno, Naoko Shigi, Ikumi Ohshio, Kentaro Jinguji, et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2014. 24. 4. 1071-1074
Dexin Kong, Shunji Aoki, Yoshihiro Sowa, Toshiyuki Sakai, Motomasa Kobayashi. Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells. Marine Drugs. 2008. 6. 3. 480-488
Naoyuki Kotoku, Atsushi Hiramatsu, Hiroaki Tsujita, Yoichi Hirakawa, Mami Sanagawa, Shunji Aoki, Motomasa Kobayashi. Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge. ARCHIV DER PHARMAZIE. 2008. 341. 9. 568-577
Shunji Aoki, Yasuo Watanabe, Daiki Tanabe, Masayoshi Arai, Hideaki Suna, Katsushiro Miyamoto, Hiroshi Tsujibo, Kazutake Tsujikawa, Hiroshi Yamamoto, Motomasa Kobayashi. Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids. Bioorganic and Medicinal Chemistry. 2007. 15. 21. 6758-6762
Taka-Aki Matsui, Yoshihiro Sowa, Hiroaki Murata, Koichi Takagi, Ryoko Nakanishi, Shunji Aoki, Masayuki Yoshikawa, Motomasa Kobayashi, Tomoya Sakabe, Toshikazu Kubo, et al. The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. International Journal of Oncology. 2007. 31. 4. 915-922

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MISC (40)：

Yasuo Watanabe, Shunji Aoki, Daiki Tanabe, Andi Setiawan, Motomasa Kobayashi. Cortistatins E, F, G, and H, four novel steroidal alkaloids from marine sponge Corticium simplex. TETRAHEDRON. 2007. 63. 19. 4074-4079
Shunji Aoki, Seok Hwan Cho, Mayumi Ono, Takashi Kuwano, Shintaro Nakao, Michihiko Kuwano, Shinsaku Nakagawa, Jian Qing Gao, Tadanori Mayumi, Masabumi Shibuya, et al. Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells. Anti-Cancer Drugs. 2006. 17. 269-278
T Noguchi, XQ Ren, S Aoki, Y Igarashi, XF Che, Y Nakajima, H Takahashi, R Mitsuo, K Tsujikawa, T Sumizawa, et al. MRP1 mutated in the L-0 region transports SN-38 but not leukotriene C-4 or estradiol-17 (beta-D-glucuronate). BIOCHEMICAL PHARMACOLOGY. 2005. 70. 7. 1056-1065
H Wei, T Itoh, M Kinoshita, N Kotoku, S Aoki, M Kobayashi. Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10. TETRAHEDRON. 2005. 61. 33. 8054-8058
青木俊二, ちょう碩かん, 小野真弓, 桑野信彦, 中川晋作, 高建青, 真弓忠範, 小林資正. 血管新生阻害活性を有する海綿由来成分bastadin類のin vivo抗腫よう効果及びその作用機序. 日本薬学会年会要旨集. 2005. 125年会. 4. 180-180

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Works (2)：

海洋生物由来の医薬シーズとしての生体機能分子の探索
2005 -
海洋生物由来の医薬シーズとしての生体機能分子の探索
2004 -

Professional career (2)：

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Association Membership(s) (4)：

ÇTMÇÒïTMéqïWìIé°ó√å§ãÜâÔÅ , 日本生薬学会 , 日本癌学会 , 日本薬学会

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