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J-GLOBAL ID：200901053795978245 Update date: Dec. 18, 2024

Nakaya Haruaki

ナカヤハルアキ | Nakaya Haruaki

Affiliation and department：
Job title： Chiba University
Homepage URL (1)： http://www.m.chiba-u.ac.jp/class/pharmacology/

Research field (1)： Pharmacology

Research keywords (2)：イオンチャネル心臓 ion channel heart , ion channel heart

Research theme for competitive and other funds (46)：

2014 - 2017 Assessment of role of Kir6.1 subunit (ATP-sensitive K+ channel) in J wave syndrome
2011 - 2014 Role of reactive oxygen species in the genesis of atrial fibrillation and novel therapeutic strategy
2008 - 2012 Explication of the regulatory mechanism of S-nitrosylation signaling
2008 - 2010 Functional role of ATP-sensitive K^+ channel in vascular endothelial cells
2007 - 2008 Role of ATP-sensitive K^+ channels in electrical remodeling associated with atrial fibrillation

2007 - 2008 ミトコンドリアを介するポストコンディショニング成立機構の解明

2006 - 2008 性ホルモンによる心筋イオンチャネル制御の検討-不整脈の性差医療の基礎戦略

2006 - 2007 細胞運動に関与するイオン輸送分子複合体の解析

2006 - 2007 Molecular and functional analysis of ATP-sensitive K^+ channel on the nuclear envelope

2005 - 2006 Cell volume regulation in T lymphocytes

2005 - 2006 The role of mitochondria ion channels in the estrogen-induced cardioprotection.

2003 - 2005 Role of Kir6.1 channels in cardiomyocytes clarified by Kir6.1-transgenic mice

2003 - 2004 Functional roles and regulation of ClC-3B chloride channel in T llymphocytes

2003 - 2004 Remodeling of mitochondrial ATP-sensitive K^+ channels in response to heart failure and atrial fibrillation

2003 - ATP感受性K+チャネル遺伝子(Kir6.2/Kir6.1)欠損マウスを用いたpreconditioning成立機構の解明

2001 - 2002 MECHANISM OF MITOCHONDRIAL K_<ATP> CHANNEL-MEDIATED CARDIOPROTECTION

2001 - 2002 Cellular mechanisms of cardioprotection by ischemic preconditioning : Functional study using Kir6.2- (Kir6.2^<-/->) and Kir6.1-deficient (Kir6.1^<-/->) mice

2001 - 2002 A new strategy for the prevention of atrial fibrillation : HCN channel blockers

2002 - T細胞のアポトーシスにおけるClC-3B Cl-チャネルの役割の解析

2000 - 2001 Cloning and functional expression of a novel C1 channel that interacts with EBP50

1999 - 2001 Pharmacological prevention of sudden cardiac death

2001 - Vasopeptidase阻害薬の心筋保護作用に関する基礎的研究:Adrenomedullinのプレコンディショニング

1999 - 2000 Role of cardiac ATP-sensitive K^+ channels clarified by Kir6.2-deficient mice

1999 - 2000 Functional roles of vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice.

2000 - 虚血・再灌流による心筋機能障害発現における細胞膜ATP感受性K+チャネルの役割:Kir6.2欠損マウスを用いた研究

1998 - 1998 心筋K^+チャネルのユビキチン化による修飾とその病態生理学的意義

1997 - 1998 Electropharmacological analysis of the regulation of the cardiac K^+ channels by inositol trisphosphate.

1996 - 1997 Electropharmacological study of receptor-mediated regulation of cardiac Na^+-activated K^+ channels

1995 - 1997 Search for a cardiac Cl^- channel blocker : Development of a novel type of antiarrhythmic drug

1994 - 1995 Pathophysiological gignificance of endothelin receptor-mediated regulation of the cardiac ATP-sensitive K channel

1994 - 1995 Neural mechanisms of cardiotoxicity of novel cytotoxins produced by methicillin-resistant Staphylococcus aureus

1994 - 心筋Na+活性化K+チャネルの構造と遮断薬に関する分子薬理学的研究

1993 - エンドセリンと虚血・再灌流不整脈:エンドセリン受容体を介するATP感受性K+チャネルの制御

1993 - メチシリン耐性黄色ブドウ球菌賛成致死毒素の心臓毒性に関する研究

1992 - 1992 心筋興奮・伝導の細胞内調節機構

1991 - 1992 Transmembrane Cl^- Movement in Cardiac Cells and Its Pathophysiological Significance

1991 - 1991 心筋興奮・伝導の細胞内調節機構

1990 - 1990 心筋興奮・伝導の細胞内調節機構

1988 - 1989 Possible Involvement of Increased Outward K^+ Current Induced by Intracellular Metabolic Derangement in Extracellular K^+ Accumulation during Myocardial Ischemia.

1986 - 1986 心筋細胞膜脂質の過酸化による細胞内Ca^<++>蓄積機構の解析

1985 - 1985 心筋細胞における過酸化脂質産生による電気生理学的異常と再灌流不整脈との関連性

1984 - 1984 PAF-acether, 心筋梗塞に伴う不整脈発現因子としての可能性

1983 - 1983 低酸素及び虚血様状態における心筋細胞内イオン活性変化と細胞活動電位変化との関連性

1982 - 1982 心虚血時の不整脈発生機序における膜燐脂質代謝物の役割

1981 - 1981 高カリウム, 低酸素, アシドーシス下における心筋活動電位の変化とCa^<++>拮抗薬の影響

1980 - 1980 Ca^<++>拮抗薬の虚血心筋伝導改善効果の作用機序, 特に細胞膜リン脂質代謝との関連につ

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Papers (266)：

Yasuhiro Watanabe, Takashi Kishimoto, Takashi Miki, Susumu Seino, Haruaki Nakaya, Akio Matsumoto. Ectopic overexpression of Kir6.1 in the mouse heart impacts on the life expectancy. Scientific reports. 2018. 8. 1. 11723-11723
Yasuhiro Watanabe, Akio Matsumoto, Takashi Miki, Susumu Seino, Naohiko Anzai, Haruaki Nakaya. Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytes. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 135. 1. 37-43
Kenji Sugawara, Kohei Honda, Yoshie Reien, Norihide Yokoi, Chihiro Seki, Harumi Takahashi, Kohtaro Minami, Ichiro Mori, Akio Matsumoto, Haruaki Nakaya, et al. A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agen. PLOS ONE. 2016. 11. 10. e0164785
Toshinao Takahashi, Toshio Nagai, Masato Kanda, Mei-Lan Liu, Naomichi Kondo, Atsuhiko T. Naito, Takehiko Ogura, Haruaki Nakaya, Jong-Kook Lee, Issei Komuro, et al. Regeneration of the Cardiac Conduction System by Adipose Tissue-Derived Stem Cells. CIRCULATION JOURNAL. 2015. 79. 12. 2703-+
Keiichiro Miura, Haruaki Nakaya, Yoshio Kobayashi. Experimental assessment of effects of antiproliferative drugs of drug-eluting stents on endothelial cells. Cardiovascular Revascularization Medicine. 2015. 16. 6. 344-347

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MISC (245)：

中谷晴昭, 渡部恭大, 松本明郎. ATP感受性K⁺チャネルの基礎と臨床不整脈発生におけるATP感受性K⁺チャネルの役割:遺伝子改変マウスを用いた解析. 心電図. 2018. 38. 2. 135-141
中谷晴昭, 松本明郎. 5. 心電学研究の進歩(循環器学2012年の進歩). 循環器専門医. 2018. 21. 1. 108-112
菅原健二, 本田洸平, 霊園良恵, 松本明郎, 森一郎, 中谷晴昭, 清野進. KATPチャネルを標的とした新規低分子化合物の同定とその特性解析. 糖尿病. 2016. 59. Suppl.1. S-193
菅原健二, 菅原健二, 本田洸平, 霊園良恵, 松本明郎, 森一郎, 中谷晴昭, 清野進. K_ATPチャネルを標的とした新規低分子化合物の同定とその特性解析. 糖尿病(Web). 2016. 59. Suppl. S.193(J-STAGE)
渡部恭大, 松本明郎, 三木隆司, 清野進, 安西尚彦, 中谷晴昭. Kir6.1gain of function mutation(S422L mutation)はマウスにおいてJ波症候群の原因となりうるか?. トランスポーター研究会年会抄録集. 2016. 11th. 56

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Lectures and oral presentations (1)：

Electrophysiologic mechanisms responsible for inotropic responses to ketamine in guinea pig and rat myocardium
(Anesthesiology 1992)

Works (12)：

Effect of bepridil on mitochondrial KATP channel
2003 - 2009
ベプリジルのミトコンドリアKATPチャネルに対する作用
2003 - 2009
Effects of bepridil on the hyperpolarization-activated inward current(Ih)
2000 - 2009
Development of antiarrhythmic drugs against atrial fibrillation
2000 - 2009
過分極誘発内向き電流(Ih)に対するベプリジルの作用
2000 - 2009

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Professional career (1)：

Doctor of Medical Science (Hokkaido University)

Awards (2)：

1993 - 第21回三越医学賞
1987 - 木村栄一賞最優秀賞

Association Membership(s) (7)：

日本循環薬理学会 , 国際心臓研究学会 , 日本生理学会 , 日本臨床薬理学会 , 日本不整脈心電学会 , 日本循環器学会 , 日本薬理学会

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