Rchr
J-GLOBAL ID：200901055052709714
Update date: Mar. 31, 2025 Taniguchi Naoyuki
谷口 直之 | Taniguchi Naoyuki
Director of Research Center and Chair of Department of Glyco-Oncology and Medical Biochemistry
Homepage URL (2)： https://oici.jp/laboratory/outline/gaiyou/
,
https://oici.jp.e.abv.hp.transer.com/laboratory/outline/gaiyou/ Research field (1)：
Pathobiochemistry
Research keywords (12)：
Glycoscience
, Glycogenes and their regulation
, Glyco-redox
, Glycosyltransferases in Volvo’s in N-glycan brabching
, Metabolism of reactive oxygen species
, Glutathione metabolism
, Glycation of protein
, Complex carbohydrates (Glycoconjugates)
, Disease Glycomics
, Glycation of Proteins
, Reactive Oxygen Species and its Metabolism
, Glycobiology
Research theme for competitive and other funds (75)： - 2018 - 2021 Modulation of cancer cells by core fucose-specific antibody
- 2017 - 2020 Therapeutic effects of keratan sulfate disaccharide and its analog against COPD
- 2015 - 2019 Elucidation of pathological mechanisms by integration glycans and redox
- 2014 - 2019 Oxygen biology: a new criterion for integrated understanding of life
- 2015 - 2018 Development of novel glycan-based drug for cancer, COPD and Alzheimer's disease
- 2014 - 2017 A novel trafficking mechanism regulated by bisecting GlcNAc, an Alzheimer's disease accelerator
- 2011 - 2014 Mechanisms of spinal cord regeneration by transplantation of matured animal-derived somatic stem cells
- 2008 - 2013 Biological Regulation of GlcNAc cycle
- 2008 - 2010 Cell transplantation for the treatment of spinal cord injury in rats-morphological study and search for humoral effective factors-
- 2001 - 2005 Integrated analyses of biological functions of sugar chains : Glycomics
- 2001 - 2001 新しいトランスメンブランシグナリングとしての糖鎖シグナルネットワーク
- 1998 - 2001 Sugar remodeling and cellular communication
- 1998 - 2000 Redox regulation by glutathione and the roles of reactive oxygen and nitrogen species
- 1998 - 2000 糖鎖遺伝子による細胞リモデリング
- 1999 - 1999 がん進展に関わる分子の診断・治療への応用
- 1997 - 1998 Development of a method for early diagnosis of diabetic of complications by detecting glycation reaction intermediates.
- 1997 - 1997 糖鎖遺伝子とその生物機能
- 1997 - 1997 糖鎖デザインと細胞機能ネットワーク
- 1997 - 1997 第5回「NOの生物学」国際学術集会の研究内容に関する企画
- 1996 - 1997 Regulation of Cellular Activity by Reactive Oxygen
- 1996 - 1997 Remodeling of cell surface oligosaccharides by introduction of glycogenes and its application
- 1996 - 1996 第5回「NOの生物学」国際学術集会の研究内容に関する企画
- 1995 - 1996 Significance of sugar moiery of recombinant glycoproteins
- 1995 - 1996 NEUROPROTECTION BY INDUCTION OF MN-SOD WITH DDS OR TRANSFECTION
- 1994 - 1996 がんの遺伝子診断
- 1993 - 1996 糖鎖遺伝子の特異性
- 1994 - 1995 Site-specific fragmentation of superoxide dismutase and DNA damage
- 1994 - 1995 Development and practical use of predictive methods of adult respiratory distress syndrome in patients with sepsis
- 1993 - 1993 糖鎖の細胞認識と癌の進展,特性に関する研究
- 1993 - 1993 腫瘍マーカーの基礎的臨床的研究
- 1993 - 1993 糖鎖遺伝子の細胞導入による癌転移能のmodulationの試み
- 1992 - 1993 腫瘍マーカーとしてのMn-スーパーオキサイドディスムターゼの癌化による発現機構
- 1992 - 1993 生涯教育のための環境教育カリキュラムの体系化と適用
- 1991 - 1993 Information Exchange on Cancer Research with North American Countries.
- 1991 - 1993 Mechanism of primary biliary cirrhosis and free radicals
- 1992 - 1992 糖鎖の細胞認識と癌の進展、特性の研究
- 1992 - 1992 腫瘍マーカーの基礎的臨床的研究
- 1992 - 1992 ガングリオシド糖鎖認識プローブの開発
- 1992 - 1992 スーパーオキシド・スーパーオキシドジスムターゼ国際会議開催準備のための総合研究
- 1992 - 1992 糖鎖遺伝子とその生物活性
- 1991 - 1992 The post-translational modification of proteins
- 1990 - 1992 Molecular Mechanism of Defense against Stress and Metabolic Regulation by Glutathione and Its Metabolites
- 1991 - 1991 癌における糖鎖合成酵素の遺伝子発現と臨床応用
- 1991 - 1991 腫瘍マ-カ-の基礎的臨床的研究
- 1991 - 1991 肝発癌過程のマ-カ-酵素の特異的発現機構と機能の解明
- 1991 - 1991 ガングリオシド糖鎖認識プロ-ブの開発
- 1991 - 1991 腫瘍マ-カ-としてのMnース-パ-オキサイドディスムタ-ゼの癌化による発現機構
- 1990 - 1991 Enzyme immunoassay of human Mn-superoxide dismutase and its clinical application : Monitoring for myocardial injury.
- 1990 - 1990 肝炎・肝癌自然発症動物(LEC)を用いた肝癌の発生と進展に関する分子病理学的研究
- 1990 - 1990 癌における糖鎖合成酵素の遺伝子発現と臨床応用
- 1990 - 1990 肝発癌過程のマ-カ-酵素の特異的発現機構と機能の解明
- 1990 - 1990 癌化におけるス-パ-オキサイドの役割
- 1990 - 1990 ガングリオシド糖鎖認識プロ-ブの開発
- 1989 - 1989 癌における糖鎖合成酵素の遺伝子発現と臨床応用
- 1989 - 1989 癌化におけるスーパーオキサイドの役割
- 1988 - 1989 Inactivation of Cu,Zn-superoxide dismutase due to glycation
- 1988 - 1988 癌化におけるスーパーオキサイドの役割
- 1987 - 1988 癌化におけるスーパーオキサイドディスムターゼの不活性化の意義
- 1987 - 1988 Development and application of ELISA using a monoclonal antibody against -glutamyltransferase sugur chains
- 1986 - 1987 Effect of physical exercise on the permeability of the cellular membrane to enzymes and its mechanism
- 1986 - 1987 Structural analysis of active site on neutral glycolipid synthase
- 1986 - 1986 癌細胞の形質発現における糖転移酵素の意義
- 1985 - 1985 肝癌のγGTPの糖鎖に特異的なモノクローン抗体を用いたELISAと悪性腫瘍の診断
- 1984 - 1985 Ca1NAc 転移酵素の構造と親和標識
- 1984 - 1984 γ-グルタミルトランスペプチダーゼの糖鎖に特異的なモノクローン抗体の作製と応用
- 1982 - 1982 環境汚染アーカーとしてのヒト肺組織の金属酵素レベル
- 1981 - 1982 フォルスマン抗原のラジオイムノアッセイの開発と臨床応用
- 1980 - 1982 腎尿細管性アシドーシスの発症機構における炭酸脱水酵素アイソザイムのVariant
- 1981 - 1981 ヒト肺組織中の金属酵素レベルと環境汚染
- 1979 - 1980 メタルキレートクロマトグラフィーによる生体中のアポ金属酵素の特異的分離法の開発
- 1978 - 1979 重金属中毒、先天性代謝異常による腎尿細管障害の研究
- 1978 - 1978 低公害地域としての北海道における化学環境の動態と人体内汚染金属の分布に関する研究
- 1976 - 1977 β_2ミクログロブリンと炭酸脱水酸素のラジオイムノアッセイの開発と腎障害への応用
- 1975 - 1975 ヒト血液の炭酸脱水酵素アイソザイムの免疫学的定量と病態的意義に関する研究
- 1974 - 1974 実験的重金属中毒におけるグルタチオン代謝に関する基礎的研究
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Yuki Ohkawa, Yoshifumi Ohashi, Reiko Fujinawa, Noriko Kanto, Yoichiro Harada, Hironobu Tanigami, Naoyuki Taniguchi. Core Fucosylation of Immunoglobulin G is a Biomarker Candidate for Monitoring Interstitial Pneumonia. Annals of Case Reports. 2024. 9. 5
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Naoyuki Taniguchi, Yuki Ohkawa, Taiki Kuribara, Junpei Abe, Yoichiro Harada, Motoko Takahashi. Roles of Glyco-redox in Epithelial Mesenchymal Transition and Mesenchymal Epithelial Transition, Cancer, and Various Diseases. Antioxidants & redox signaling. 2024. 41. 13-15. 910-926
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大川 祐樹, 貫戸 紀子, 國政 啓, 西野 和美, 向井 幹夫, 清家 正博, 吾妻 安良太, 原田 陽一郎, 顧 建国, 谷口 直之. 新規抗コアフコシル化IgG抗体による肺癌患者の同定とそのCCL2による制御(Anti-core fucosylated IgG antibody identifies lung cancer patients and its regulation by CCL2). 日本癌学会総会記事. 2024. 83回. E-3052
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Emma Lee Johnson, Yuki Ohkawa, Noriko Kanto, Reiko Fujinawa, Taiki Kuribara, Eiji Miyoshi, Naoyuki Taniguchi. The S1 spike protein of SARS-CoV-2 upregulates the ERK/MAPK signaling pathway in DC-SIGN-expressing THP-1 cells. Cell stress & chaperones. 2024. 29. 2. 227-234
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大川 祐樹, 貫戸 紀子, 太田 芙美, 木塚 康彦, 清家 正博, 吾妻 安良太, 顧 建国, 原田 陽一郎, 谷口 直之. 新規コアフコシル化IgG抗体による肺癌の診断法. 日本分子腫瘍マーカー研究会誌. 2024. 39. 31-31
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谷口 直之. 非酵素的糖化反応(メイラード反応)の疾患における役割と今後の展望(5)疾患におけるMaillard反応と今後の展望 グリケーションとグリコシレーションが関わる酸化的ストレスとアルツハイマー病. BIO Clinica. 2022. 37. 13. 1193-1198
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前田 賢人, 原田 陽一郎, 大川 祐樹, 谷口 直之. N-アセチルグルコサミン転移酵素Vは肺がん細胞において抗がん剤ゲフィチニブ耐性を誘導する. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1T02a-05
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大川 祐樹, 木塚 康彦, 高田 美咲, 中の 三弥子, 伊藤 恵美, Mishra Sushil K., 赤塚 晴奈, 前田 賢人, 原田 陽一郎, 谷口 直之. グライコプロテオミクスによる糖転移酵素GnT-IIIのタンパク質認識機構の解析. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3T02a-07
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井原 秀之, 岡田 貴裕, 谷口 直之, 池田 義孝. ヒトα1,6-フコース転移酵素(FUT8)の酵素活性に影響を及ぼすα-ヘリカル(コイルドコイル)ドメイン内疎水性アミノ酸残基の探索. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 2P-029
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前田 賢人, 原田 陽一郎, 大川 祐樹, 谷口 直之. N型糖鎖修飾の阻害はヒト非小細胞肺がん株PC-9のゲフィチニブ耐性機構をMET遺伝子増幅に収束させる(Targeting N-glycosylation converges the gefitinib resistance mechanism to MET amplification in human NSCLC PC-9 cells). 日本癌学会総会記事. 2022. 81回. J-2028
ｍore...- 糖鎖を標的とした肺がん、およびその全判病変の診断・治療法の開発をめざして
ダイアローグ株式会社 2022
- Glycoscience : basic science to applications : insights from the Japan consortium for glycobiology and glycotechnology (JCGG)
Springer 2019 ISBN:9789811358555
- Medical Biochemistry With STUDENT CONSULT online access 4e(Medical Biochemistry)
Elsevier Japan, Maruzen Publishing (Sales) 2018 ISBN:9784621301692
- Essentials of Glycobiology 3rd Edition
Cold Spring Harbor Laboratory Press 2017 ISBN:9781621821328
- Glycoscience : biology and medicine
Springer 2015 ISBN:9784431548409
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Glyco-redox, integration of glycobiology and redox biology and the roles in various diseases under oxidative stress
(Engineering Conference on "Glycomedicine-unraveling the paracentral dogma" 2024)
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Expectations for JHUPO: Lessons from the Human Disease Glycomics Initiative (HGPI)
(JHUPO 2021)
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Branching N-glycans and their roles in disease onset, biomarker discovery and treatment.
(GlycoBioTec 2019 2019)
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Branching N-glycans and their roles in disease onset, biomarker discovery and tretment
(GlycoBioTecd 2019 2019)
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Role of branched N-glycans in disease
(International Polysaccharide Reserach Center opening Ceremony/Seminar 2018)
ｍore...- 1972 - 1973 Hokkaido University School of Medicine Department of Biochemistry
- 1968 - 1972 Hokkaido University Graduate School of Medicine The 1st Department of Biochemistry
- 1970 - 1970 Osaka University Institute for Protein Research Department of Enzyme
- 1967 - 1968 Hokkaido University Hokkaido University Hospital Internship
- 1963 - 1967 Hokkaido University Faculty of Medicine Medical School
- 1961 - 1963 Hokkaido University College of Liberal Arts Premedical Course
- 1958 - 1961 Sapporo Minami High School
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- Doctor of Medical Science,(equivalent for PhD) (Hokkaido University)
- 2019/04 - 現在 Osaka International Cancer Institute Research Center Director of Research Center and Chair of the Department of Glyco-Oncology (concurrent duties)
- 2018/04 - 現在 Osaka International Cancer Institute RGlyco-Oncology Glyco-Oncology Department of Glyco-Oncology Department head
- 2006/04 - 現在 Osaka University Professor Emeritus
- 2024/04 - Osaka International Cancer Institute Department of Glyco-Oncology and Medical Biochemsityr Directoer of Research Instituet and Chair
- 2024/04 - RIKEN Honarable fellow
- 2013/04 - 2018/03 RIKEN Advanced Science Institute、Department of Chemical Biology Group Director of Systems Glycobiology Reserach Group
- 2018/01 - Academia Sinica Genomic Research Institute Researcg Adviser
- 2011/04 - 2015/03 Osaka University、Institute of Scientific and Industrial Science Osaka University-RIKEN Alliance Laboratory Gust Professor
- 2008/10 - 2012/03 RIKEN Advanced Science Institute Frontier Research System Systems Glycobiology Research Group Group Director
- 2012/03 - 理研 フロンティア=システム糖鎖グループ グループリーダー
- 2009/04 - 2011/03 Osaka University, institute of Scientific and Industrial Research Endowed Division of Disease Glycomics Endowed Chair Professor
- 2006/04 - 2009/03 Osaka University Institute for Microbial Diseases Division of Disease Glycomics, Endowed Department (Seikagaku Corporation) Endowed Chair Professor
- 1998/04 - 2006/03 Graduate School of Medicine Deparment of Biochemistry and Molecular Biology Full Professor
- 1986/04 - 1998/03 Osaka University Medical Shool Full Professor
- 1996 - 1997 Shanghai Medical University Departm;ent of Biochemistry Visiting Professor
- 1987/11 - 1988/11 Shanghai Medical University Department of Biochemistry Visiting Professor
- 1979/06 - 1986/03 Hokkaido University Faculty of Medicine, Cancer Institite Associate Professor
- 1977/04 - 1979/05 Hokkaido University Department of Environmental Medicine, Graduate School of Environmental Science Associate Professor
- 1976/10 - 1977/10 Cornell University Medical School Department of Biochemistry 客員教授
- 1975/05 - 1977/03 Hokkaido University Faculty of Medicine, Department of Hygine and Preventive Medicine Lecturer
- 1973/04 - 1973/05 Hokkaido University Faculty of Medicine, Department of Hygine and Preventive Medicine Research Assistant
- 1972/04 - 1973/03 Postdoctoral fellow at Hokkaido University Faculty of Medicine !st Department of Biochemistry Research fellow
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- 2019/04 - 現在 Sapporo Cancer Seminar Foundation Councilor, vice-chair
- 2019/01 - 現在 Sapporo Cancer Seminar Foundation Vice-Chairman of the Board of Trustees
- 2007 - 現在 UBMB Life Editorial board member
- 2007/01 - 現在 Japanese Biochemical Society, Japanese Cancer Association , Japanese Society for Carbohydrate Reseaach Honorary member
- 2005/01 - 現在 Proteomics Clinical Applications Senior Editor
- 2001/01 - 現在 Biochemical Biophysical Research Communicairton Editorial board
- 1996/01 - 現在 Glycobiology Editorial board member
- 1993/01 - 現在 Protein Expression and Purification Editorial Board Member
- 2015/09 - 2024/12 Elsevier Inc Editor for Biochemical Biophysical Research Communications
- - 2024/04 Mishima Kaiun Memorial Foundation Chair of the board of trustees
- 2011/06 - 2023/05 公益財団法人微生物化学研究会 評議員
- 2010/01 - 2018/12 Sapporo Cancer Seminar Foundation Vice-president
- 2002/01 - 2018/12 International Glycoconjugate Society Review editor
- 2002/01 - 2018 Antioxidant and Redox Signaling Editorial board member
- 2013/01 - 2017/12 Japan Society for Glycoscience and Glycotechnology (GCGG) President
- 2006/01 - 2017/12 Cellular and Molecular Life Sicences Editorial board member
- 2014/11 - 2015/10 Society for Glycobiology President
- 2014 - Society for Glycobiology (USA) President
- 1998/01 - 2013/12 Journal of Biological Chemistry Editorial Board Member
- 2013 - 第12回ヒトプロテオーム国際会議 Co-Chair
- 2005/10 - 2011/09 Science Council of Japan The 20th and 21th Member of Science Council of Japan
- 2006/01 - 2010/12 Journal of Biochemistry Editor-in-Chief
- 2004/01 - 2009/12 Human Disease Proteomics/Glycome Initiative Chair
- 2002/10 - 2009/09 Japan Science and Technology Agency CREST Evaluation of Biological funciton of sugar chains and application tech nology
- 2006/04 - 2009/03 Science Council pf Japan Chair of the 170th Committee of Redox Life Science
- 2002/04 - 2009/03 CREST Research administrater
- 2001 - 2007 日本学術振興会科学研究費委員会専門委員
- 2006/01 - 2006/12 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress Secretary General
- 2004/05 - Japanese Nitric Oxide Society and International NO meeting President and Co-chair
- 2003 - 2004 日本NO学会 副会長
- 2001 - 2004 文部科学省科学技術学術審議会専門委員
- 1997 - 2004 日本学術会議会員
- 2004 - 日本糖質学会 理事 名誉会員
- 2002 - 日本医学会 評議員
- 2002 - 日本電気泳動学会 副会長
- 2001/10 - 2001/10 Japanese Biochemical Society Meeting president
- 1993/04 - 2000/03 Ministry of Educaiton, Science and Culture. Science and International Affairs Bureau Expert advisor in the coucil
- 2000 - International Glycoconjugate Organization National representative
- 1998 - 日本癌学会 名誉会員
- 1995 - アメリカ生化学会・分子生物学会 名誉会員
- 1989 - 1994 Japan Maillard Reaction Society President
- 1992 - 日本臨床化学会 評議員
- 1992 - 日本生化学会 理事、常任理事、JB部門編集長、常務理事、会頭 名誉会員
- 1991 - (アメリカ癌学会)American Association for Cancer Research corresponding member
- 1985 - New York Academy of Science メンバー
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- 2018/10 - Society for Glycobiology (US) Karl Meyer Lectureship Award Lessons from glycosyltransferase genes invovled in the branching of N-glycans
- 2016 - The Order o the Sacred Treasure, Gold Rays with Neck Ribbon
- 2011 - Japan Academy Prize
- 2010/10 - WILEY BLackWELL The FEBS Journal Top-Cited Paper Award Branched N-glycans regulate the biological functions of integrins and cadherins
- 2010/04 - Northeastern University. Barnette Lectureship Why is Sweet Science Important?
- 2009 - Human Proteome Organization HUPO Distinguished Service Award Contritubion to HUPO
- 2008/06 - 33rd FEBS Congress and 11th IUBMB Conference IUBMB Medal Pioneering work in the filed of glyhcoscience and particularly on the importance of N-glycans in disease
- 2005 - Medal with Purple Ribbon, government of Japan
- 2003 - Doctor Honaris Causa, Medical and Pharmaceutical University of Cluj-Napoca, Romania
- 2002/11 - Takeda Medical Award Glycosyltransferase genes and analysis of new functions
- 2001 - Doctor Honaris Causa, Henri Poincare University, II Nancy, France
- 2001 - Medical Award, The Japan Medical Association
- 1995 - NHonorary member for the American Society for Biochemistry and Molecular Biology
- 1993 - Journal of Biochemistry Award
- 1989 - 安田記念医学賞
- 1982 - Young Investigator Award, Japan Cancer Association
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JHUPO Honorary member
, Humsn Pfoteome Organization
, 日本糖質学会
, 日本医学会
, 日本電気泳動学会
, 国際糖鎖生物学会
, アメリカ生化学会・分子生物学会
, 日本NO学会
, アメリカ化学会
, 日本糖尿病学会
, 日本臨床化学会
, New York Academy of Science
, (アメリカ癌学会)American Association for Cancer Research
, 日本癌学会
, 日本生化学会
