Kiminori Nakamura

ナカムラキミノリ | Kiminori Nakamura

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://altair.sci.hokudai.ac.jp/infsig/

Research field (2)： Immunology , Oral medicine

Research keywords (11)：腸内環境 , Regenerative medicine , Inflammatory bowel disease , Infectious disease , Stem cell , Paneth cell , Intestine , defensin , Antimicrobial peptides , Innate immunity , Mucosal immunology

Research theme for competitive and other funds (15)：

2022 - 2024 母乳オリゴ糖の腸管上皮幹細胞ニッシェを介した腸内環境発達メカニズムの解明
2021 - 2024 PHRを活用した機械学習モデルによる心血管病の重症化予防を目指した研究
2020 - 2023 Paneth細胞が担う腸内細菌叢の形成からみた疾患リスク上昇メカニズムの理解
2017 - 2020 Elucidation of homeostatic mechanism via intestinal environment regulated by oral bacteria
2017 - 2019 口腔細菌が規定する腸内環境を介した生体恒常性維持機能の解明

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Papers (87)：

Chizuru Kimura, Kazuhito Miura, Yutaka Watanabe, Haruhisa Baba, Kimiya Ozaki, Akira Hasebe, Tokiyoshi Ayabe, Kiminori Nakamura, Shinji Nakaoka, Katsuhiko Ogasawara, et al. Association between oral frailty and Prevotella percentage in the oral microbiota of community-dwelling older adults who participated in the CHEER Iwamizawa project, Japan. Journal of oral rehabilitation. 2024
Sakura YONOICHI, Yukako HARA, Yuya ISHIDA, Asuka SHODA, Mako KIMURA, Midori MURATA, Sarika NUNOBIKI, Makiko ITO, Ayano YOSHIMOTO, Youhei MANTANI, et al. Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice. Journal of Veterinary Medical Science. 2024
Li Gan, Yuga Inamura, Yu Shimizu, Yuki Yokoi, Yuki Ohnishi, Zihao Song, Yasuhiro Kumaki, Takashi Kikukawa, Makoto Demura, Masaaki Ito, et al. A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and Metabolites. Metabolites. 2023. 13. 9. 1003-1003
Yi Wang, Yuchi Song, Shaonan Yan, Rina Hiramine, Yuki Ohnishi, Yuki Yokoi, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe, Tomoyasu Aizawa. Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions. Antibiotics. 2023. 12. 6. 1047-1047
Zihao Song, Yuki Ohnishi, Seiji Osada, Li Gan, Jiaxi Jiang, Zhiyan Hu, Hiroyuki Kumeta, Yasuhiro Kumaki, Yuki Yokoi, Kiminori Nakamura, et al. Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis. Metabolites. 2023. 13. 5. 611-611

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MISC (28)：

中村公則. Paneth 細胞・αディフェンシンによる自然免疫機能を介した腸内細菌叢制御. 臨床化学特集:消化管細菌と全身性疾患. 2023. 52. 3. 170
綾部時芳, 中村公則. 【腸と健康:腸オルガノイドが挑む次世代バイオモデル】自然免疫と共生を紐解く小腸オルガノイドenteroid. 医学のあゆみ. 2019. 270. 11. 1059-1063
中村公則, 菊池摩仁, 綾部時芳. 【腸内菌叢はコントロールできるか?】抗菌ペプチドαディフェンシンによる腸内細菌叢の制御. 腸内細菌学雑誌. 2019. 33. 3. 129-135
中村公則. キーワード(No.16) パネート細胞. 消化器病学サイエンス. 2019. 3. 1. 43-43
綾部時芳, 中村公則. 【生体バリア粘膜や皮膚を舞台とした健康と疾患のダイナミクス】(第1章)生体バリアを支える分子・細胞・組織基盤細胞分泌物による化学的バリア抗菌ペプチドによる自然免疫. 実験医学. 2017. 35. 7. 1078-1083

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Patents (10)：

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Books (1)：

食品免疫学事典日本食品免疫学会(編)
朝倉書店 2021

Lectures and oral presentations (133)：

Paneth cell・α-defensin to regulate gut microbiota in health and disease
(2024)
Selective Paneth cell granule secretion in response to pathogenic and commensal bacteria in enteric mucosal immunity
(The 52nd Annual Meeting of the Japanese Society for Immunology 2024)
Establishment of a high-efficient method for generating transgenic enteroid revealing intestinal epithelial function
(2023)
Paneth細胞・αディフェンシンによる腸内環境制御と健康維持
(iSeminar(異分野融合研究セミナー) 2023)
Paneth細胞・αディフェンシンによる自然免疫機能を介した腸内細菌叢制御
(日本食品免疫学会第19回学術大会シンポジウム「腸内環境と免疫システム」 2023)

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Education (2)：

2000 - Health Sciences University of Hokkaido Graduate School of Dentistry
1996 - Health Sciences University of Hokkaido School of Dentistry

Professional career (1)：

Ph.D (Health Sciences University of Hokkaido)

Work history (6)：

2023/04 - 現在北海道大学大学院先端生命科学研究院教授
2013 - Hokkaido University Faculty of Advanced Life Science
2011 - Hokkaido University Faculty of Advanced Life Science
2009 - Hokkaido University Faculty of Advanced Life Science
2005 - 札幌医科大学医学部分子医学研究部門講師

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Association Membership(s) (6)：

日本食品免疫学会 , THE JAPANESE SOCIETY FOR IMMUNOLOGY , JAPANESE SOCIETY OF GASTROENTEROLOGY , THE JAPANESE CANCER ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 腸内細菌学会

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