Rchr
J-GLOBAL ID:200901059484331173
Update date: Sep. 12, 2024
Mishima Masaki
Mishima Masaki | Mishima Masaki
Affiliation and department:
Job title:
Associate Professor
Homepage URL (1):
https://www.ps.toyaku.ac.jp/bunshikino/
Research field (3):
Molecular biology
, Biophysics
, Structural biochemistry
Research keywords (6):
分子生物物理学
, 構造生物学
, 生物物理学
, 創薬科学
, 核磁気共鳴学法
, ケミカルバイオロジー
Research theme for competitive and other funds (23):
- 2024 - 2026 シアノバクテリオクロムの光変換の構造基盤
- 2022 - 2025 シアノバクテリア光センサーのプロトン化状態の解明に資する構造基盤
- 2019 - 2022 A multidisciplinary approach to establish the structural basis of dosage compensation
- 2017 - 2019 Structural and dynamical studies of multidomain protein
- 2015 - 2018 Structural basis of transcriptional repression by SRA, a long non-coding RNA
- 2015 - 2017 Dynamical study of multi-domain kinases reconstructed by domain ligation
- 2013 - 2016 Study of Streptomyces conjugation mechanism and the application for artificial genome evolution
- 2010 - 2016 Structural basis of cell-signaling complexes mediating signal perception, transduction and responses.
- 2010 - 2016 Structural biology of animal and plant signaling proteins
- 2013 - 2015 チューブリンチロシンリガーゼとチューブリン複合体の構造解析
- 2013 - 2015 Structural study of reconstitued full length PKC
- 2012 - 2014 常磁性プローブを利用した準安定な複合体の立体構造解析
- 2011 - 2012 Structural studies on tubulin tyrosine ligase and its application.
- 2010 - 2012 解析困難な蛋白質の高精度立体構造決定法の開発
- 2010 - 2011 In-cell NMRによる生細胞内蛋白質分子動態の解析
- 2010 - 2011 常磁性緩和効果を利用した準安定な複合体の構造解析
- 2009 - 2010 Structural studies of the regulatory factor of a functional RNA, steroid hormone RNA activator.
- 2007 - 2010 Structural biology of cytoskeletal control by dynamic protein complex formation.
- 2008 - 2009 In-Cell NMRを用いた生細胞内蛋白質の物性・動態解析法の開発
- 2008 - 2009 新規抗がん薬のデザイン、探索を目指した微小管プラス端集積因子の構造解析
- 2007 - 2008 細胞膜を介した金属の恒常性維持に関与する蛋白質の構造生物学
- 2006 - 2007 Structural basis of IRE1 mRNA splicing mechanism
- 2004 - NMRによる酸化損傷アデニン分子認識機構の解析
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Papers (62):
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Takayuki Nagae, Mitsuhiro Takeda, Tomoyasu Noji, Keisuke Saito, Hiroshi Aoyama, Yohei Miyanoiri, Yutaka Ito, Masatsune Kainosho, Yuu Hirose, Hiroshi Ishikita, et al. Direct evidence for a deprotonated lysine serving as a H-bond “acceptor” in a photoreceptor protein. Proceedings of the National Academy of Sciences. 2024. 121. 36
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Takayuki Nagae, Yuya Fujita, Tatsuya Tsuchida, Takanari Kamo, Ryoka Seto, Masako Hamada, Hiroshi Aoyama, Ayana Sato-Tomita, Tomotsumi Fujisawa, Toshihiko Eki, et al. Green/red light-sensing mechanism in the chromatic acclimation photosensor. Science Advances. 2024. 10. 24
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Hiroshi Aoyama, Yusuke Iizuka, Ryouta Kawanishi, Kazutaka Shibatomi, Yuki Arakawa, Hideto Tsuji, Yuu Hirose, Masaki Mishima. Efficient synthesis of γ-oxo carboxylic esters and isotope-labeled 5-aminolevulinic acid (5-ALA) by Pd(OAc)2/phosphonium tetrafluoroborates catalyzed Fukuyama coupling reaction. Tetrahedron Letters. 2023. 123
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Pooppadi Maxin Sayeesh, Teppei Ikeya, Haruka Sugasawa, Riki Watanabe, Masaki Mishima, Kohsuke Inomata, Yutaka Ito. Insight into the C-terminal SH3 domain mediated binding of Drosophila Drk to Sos and Dos. Biochemical and biophysical research communications. 2022. 625. 87-93
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Naoki Takahashi, Tomoki Iguchi, Minpei Kuroda, Masaki Mishima, Yoshihiro Mimaki. Novel Oleanane-Type Triterpene Glycosides from the Saponaria officinalis L. Seeds and Apoptosis-Inducing Activity via Mitochondria. International journal of molecular sciences. 2022. 23. 4
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MISC (234):
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大久保里佳, 堀川皓央, 伊藤かおり, 菱倉直樹, 渡邉吏輝, 三島正規, 三島正規, 猪股晃介, 小手石泰康, 澤井仁美, et al. Structural analysis of the rhizobial multi-domain protein FixJ by heteronuclear multidimensional NMR spectroscopy. Abstracts. Annual Meeting of the NMR Society of Japan. 2023. 62nd (CD-ROM)
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菱倉直樹, 渡邉吏輝, 大久保里佳, 堀川皓央, 伊藤かおり, 三島正規, 三島正規, 猪股晃介, 小手石泰康, 澤井仁美, et al. Functional analysis of FixL-FixJ two-component signalling system by solution NMR. Abstracts. Annual Meeting of the NMR Society of Japan. 2023. 62nd (CD-ROM)
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大久保里佳, 大久保里佳, 池谷鉄兵, 渡邉吏輝, 菱倉直樹, 三島正規, 猪股晃介, 小手石泰康, 澤井仁美, 城宣嗣, et al. A paramagnetic NMR study on a rhizobial multi-domain protein, FixJ. Abstracts. Annual Meeting of the NMR Society of Japan. 2022. 61st
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三島正規. NMR Analyses of Protonation State of the Cyanobacterial Photosensor Protein. 波紋. 2022. 32. 1
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飯塚佑介, 永江峰幸, 青山洋史, 伊集院良祐, 伊藤隆, 広瀬侑, 三島正規. シアノバクテリアの光センサーのX線結晶構造解析と,NMRによるプロトン化状態の解析. 日本蛋白質科学会年会プログラム・要旨集. 2022. 22nd (Web)
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Education (2):
- - 2001 Nara Institute of Science and Technology Graduate School of Biological Sciences Department of Molecular Biology
- - 1996 Nagoya City University
Professional career (1):
- 博士(バイオサイエンス) (奈良先端科学技術大学院大学)
Work history (5):
- 2021/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
- 2006/04 - 2021/03 東京都立大学(首都大学東京) 理学研究科(理工学研究科) 准教授
- 2007/02 - 2007/10 日本学術振興会海外特別研究員 派遣先 欧州分子生物学研究所(EMBL Heidelberg)
- 2001/12 - 2006/03 Nara Institute of Science and Technology
- 2001/04 - 2001/12 横浜市立大学( 木原記念生命科学振興財団) 博士研究員
Association Membership(s) (5):
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, 日本核磁気共鳴学会
, 日本生物物理学会
, 日本分子生物学会
, 日本薬学会
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