Rchr
J-GLOBAL ID:200901059484331173
Update date: Feb. 16, 2025 Mishima Masaki
Mishima Masaki | Mishima Masaki
Affiliation and department: Job title:
Associate Professor
Homepage URL (1): https://www.ps.toyaku.ac.jp/bunshikino/ Research field (3):
Molecular biology
, Biophysics
, Structural biochemistry
Research keywords (6):
分子生物物理学
, 構造生物学
, 生物物理学
, 創薬科学
, 核磁気共鳴学法
, ケミカルバイオロジー
Research theme for competitive and other funds (23): - 2024 - 2026 シアノバクテリオクロムの光変換の構造基盤
- 2022 - 2025 シアノバクテリア光センサーのプロトン化状態の解明に資する構造基盤
- 2019 - 2022 A multidisciplinary approach to establish the structural basis of dosage compensation
- 2017 - 2019 Structural and dynamical studies of multidomain protein
- 2015 - 2018 Structural basis of transcriptional repression by SRA, a long non-coding RNA
- 2015 - 2017 Dynamical study of multi-domain kinases reconstructed by domain ligation
- 2013 - 2016 Study of Streptomyces conjugation mechanism and the application for artificial genome evolution
- 2010 - 2016 Structural basis of cell-signaling complexes mediating signal perception, transduction and responses.
- 2010 - 2016 Structural biology of animal and plant signaling proteins
- 2013 - 2015 チューブリンチロシンリガーゼとチューブリン複合体の構造解析
- 2013 - 2015 Structural study of reconstitued full length PKC
- 2012 - 2014 常磁性プローブを利用した準安定な複合体の立体構造解析
- 2011 - 2012 Structural studies on tubulin tyrosine ligase and its application.
- 2010 - 2012 解析困難な蛋白質の高精度立体構造決定法の開発
- 2010 - 2011 In-cell NMRによる生細胞内蛋白質分子動態の解析
- 2010 - 2011 常磁性緩和効果を利用した準安定な複合体の構造解析
- 2009 - 2010 Structural studies of the regulatory factor of a functional RNA, steroid hormone RNA activator.
- 2007 - 2010 Structural biology of cytoskeletal control by dynamic protein complex formation.
- 2008 - 2009 In-Cell NMRを用いた生細胞内蛋白質の物性・動態解析法の開発
- 2008 - 2009 新規抗がん薬のデザイン、探索を目指した微小管プラス端集積因子の構造解析
- 2007 - 2008 細胞膜を介した金属の恒常性維持に関与する蛋白質の構造生物学
- 2006 - 2007 Structural basis of IRE1 mRNA splicing mechanism
- 2004 - NMRによる酸化損傷アデニン分子認識機構の解析
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Papers (65): -
Akio Horikawa, Rika Okubo, Naoki Hishikura, Riki Watanabe, Kaori Kurashima-Ito, Pooppadi Maxin Sayeesh, Kohsuke Inomata, Masaki Mishima, Hiroyasu Koteishi, Hitomi Sawai, et al. Backbone and side-chain 1H, 13C and 15N resonance assignments and secondary structure determination of the rhizobial FixJ. Biomolecular NMR Assignments. 2025
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Mitsuhiro Takeda, Rino Saito, Sho Konno, Takayuki Nagae, Hiroshi Aoyama, Sosuke Yoshinaga, Hiroaki Terasawa, Akihiro Taguchi, Atsuhiko Taniguchi, Yoshio Hayashi, et al. Backbone resonance assignments of the C-terminal thioesterase domain of tyrocidine synthetase C. Biomolecular NMR assignments. 2024
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Kei Wada, Kenji Kobayashi, Iori Era, Yusuke Isobe, Taigo Kamimura, Masaki Marukawa, Takayuki Nagae, Kazuki Honjo, Noriko Kaseda, Yumiko Motoyama, et al. Protonation/deprotonation-driven switch for the redox stability of low-potential [4Fe-4S] ferredoxin. eLife. 2024
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Takayuki Nagae, Mitsuhiro Takeda, Tomoyasu Noji, Keisuke Saito, Hiroshi Aoyama, Yohei Miyanoiri, Yutaka Ito, Masatsune Kainosho, Yuu Hirose, Hiroshi Ishikita, et al. Direct evidence for a deprotonated lysine serving as a H-bond “acceptor” in a photoreceptor protein. Proceedings of the National Academy of Sciences. 2024. 121. 36
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Takayuki Nagae, Yuya Fujita, Tatsuya Tsuchida, Takanari Kamo, Ryoka Seto, Masako Hamada, Hiroshi Aoyama, Ayana Sato-Tomita, Tomotsumi Fujisawa, Toshihiko Eki, et al. Green/red light-sensing mechanism in the chromatic acclimation photosensor. Science Advances. 2024. 10. 24
more... MISC (251): -
荒谷英寿, 土田竜也, 添田貴宏, 広瀬侑, 三島正規, 宇梶裕. Total Synthesis of Regioselectively 15N-Labeled Tetrapyrrole Chromophores. 日本化学会春季年会講演予稿集(Web). 2024. 104th
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武田光広, 永江峰幸, 青山洋史, 宮ノ入洋平, 会津貴大, 広瀬侑, 甲斐荘正恒, 伊藤隆, 三島正規. Visualizing deprotonation state of the side-chain amino group of lysine in proteins based on the NMR H/D isotope shift effect. 日本薬学会年会要旨集(Web). 2024. 144th
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斉藤梨乃, 永江峰幸, 武田光広, 今野翔, 青山洋史, 谷口敦彦, 林良雄, 三島正規. Structural studies on the cyclization of the non-ribosomal cyclic peptide tyrocidine by the thioesterase domain TycC-TE. 日本薬学会年会要旨集(Web). 2024. 144th
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青山洋史, 漆山更紗, 永江峰幸, 武田光広, 三島正規. The Specific Effects of Phthalimide on Molecular Recognition by Serine Proteases. 日本薬学会年会要旨集(Web). 2024. 144th
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永江峰幸, 飯塚佑介, 青山洋史, 宮ノ入洋平, 神野智司, 伊藤隆, 広瀬侑, 三島正規. Structural basis for cyanobacteriochrome towards the development of optogenetics. 日本薬学会年会要旨集(Web). 2023. 143rd
more... Education (2): - - 2001 Nara Institute of Science and Technology Graduate School of Biological Sciences Department of Molecular Biology
- - 1996 Nagoya City University
Professional career (1): - 博士(バイオサイエンス) (奈良先端科学技術大学院大学)
Work history (5): - 2021/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
- 2006/04 - 2021/03 東京都立大学(首都大学東京) 理学研究科(理工学研究科) 准教授
- 2007/02 - 2007/10 日本学術振興会海外特別研究員 派遣先 欧州分子生物学研究所(EMBL Heidelberg)
- 2001/12 - 2006/03 Nara Institute of Science and Technology
- 2001/04 - 2001/12 横浜市立大学( 木原記念生命科学振興財団) 博士研究員
Association Membership(s) (5):
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, 日本核磁気共鳴学会
, 日本生物物理学会
, 日本分子生物学会
, 日本薬学会
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