Rchr
J-GLOBAL ID：200901059904850554
Update date: Sep. 17, 2024
Kurihara Hiroki
クリハラ ヒロキ | Kurihara Hiroki
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://bio.m.u-tokyo.ac.jp/home-j.html
Research field (2)：
Cardiology
, Medical biochemistry
Research keywords (11)：
GPCR
, Homeobox gene
, Endothelin
, Organogenesis
, Morphogenesis
, Development
, Early embryogenesis
, Angiogenesis
, Neural crest cells
, Craniofacial development
, Heart
Research theme for competitive and other funds (57)：
- 2022 - 2027 Integrative understanding of cardiac and mediastinal diseases based on the common developmental origins
- 2022 - 2025 Cooperation of neural crest cells, macrophages, and vascular endothelial cells during cardiac development.
- 2021 - 2023 縦隔間葉系の器官発生及び疾患発症における意義の解明
- 2019 - 2022 Significance of the inflammatory cascade within vascular wall of the cerebral aneurysms formation
- 2019 - 2022 Comprehensive research in morphogenesis of the cardiac outflow tract
- 2019 - 2022 Integrative understanding of the development, evolution, disease and regeneration of the coronary circulatory system based on multicellular interaction
- 2017 - 2019 Creation of vascular structures from non-vascular cells
- 2016 - 2019 Related elucidation of the tissue-specific pudding metabolism state and lifestyle-related disease
- 2016 - 2018 Elucidation of the mechanism of endothelin type A receptor gene disorder by animal model
- 2015 - 2018 Exploring the mechanism of cardiac development and regeneration based on diverse cellular origins
- 2014 - 2016 Methanism of metabolic regulation and aging in mammalian eggs
- 2014 - 2016 Characterization of neural crest cells migrating into the heart
- 2013 - 2016 Elucidation of pathogenesis of the onset of lifestyle-related diseases due to oxidative stress derived from diet components
- 2012 - 2016 Establishment of the concept of broad organ-forming network in cardiovascular formation and models for tissue reconstruction
- 2011 - 2013 Investigation of the function of non-coding RNA in the morphogenesis
- 2011 - 2012 着床前胚におけるストレス応答の分子機構と疾患発症基盤としての意義
- 2011 - 2012 The role of resistin-like molecules in natural immune system involving insulin resistance.
- 2011 - 2012 Qualitative improvement of aged eggs and development of technologies supporting ART at later ages
- 2009 - 2011 Identification of novel cell lineages contributing to cardiovascular development and clarification of mechanisms underlying their fate determination
- 2009 - 2010 受精前後のストレス応答におけるエピジェネティック制御因子の役割と疾患発症への影響
- 2007 - 2010 The investigation of molecular mechanisms underlying refractory respiratory diseases and exploration of novel therapeutic targets
- 2006 - 2007 クローン技術を用いた血管病治療モデルの確立
- 2006 - 2007 Molecular mechanism for intercellular interactions involved in cardiovascular a〓craniofacial development
- 2006 - 2007 Analysis of cardiovascular development and pathophysiology by gene engineering of the endothelin system in mice
- 2004 - 2006 クローン技術を用いた血管細胞分化機構の解明
- 2003 - 2006 Exploration of therapeutic targets for refractory inflammatory lung diseases and development of novel therapeutic strategies
- 2005 - 2005 プロテオーム解析によるインスリン感受性調節機構の解明と新規治療ターゲットの発見
- 2004 - 2005 Mechanism for the involvement of the endothelin system in craniofacial and cardiovascular development
- 2004 - 2005 Molecular cascades underlying the integration of cell differentiation and morphogenesis in cranial/cardiac neural crest development
- 2004 - 2004 心臓大血管の形態形成の分子機構の解明
- 2003 - 2004 未知の抗菌ペプチドの探索および炎症性肺疾患発症制御の可能性
- 2003 - 2004 神経堤細胞の分化メカニズムの解析と可塑性の評価
- 2002 - 2003 神経堤細胞に由来する血管平滑筋前駆細胞の単離同定と分化系譜の確立
- 2002 - 2003 Molecular signaling mechanisms underlying cardiovascular and branchial morphogenesis
- 2000 - 2002 Molecular mechanisms underlying ARDS and development of novel therapeutic strategies using genetically-engineered mice
- 2000 - 2002 Estimation of Susceptibility to and Prognosis of Cardiovascular Diseases Based on Genetic Polymorphism and Its Application to Drug Discoveries
- 1998 - 2002 Pathophysiological Role of Adrenomedullin in Cardiovascular Disease and Therapeutic Application of Adrenomedullin
- 2001 - 2001 心大血管発生の分子機構と先天性疾患のメカニズム
- 2000 - 2001 Investigation of the genetic basic of the multiple risk factor syndrome using model organisms
- 1999 - 2001 Development of inhibitors for the activation of cardiovascular interstitial ceils
- 2000 - 2000 神経堤細胞から血管平滑筋細胞への分化機構の解明
- 1997 - 1999 心血管系の発生分化とその分子機構の解析
- 1997 - 1998 Molecular biology research concernig mandible face growth of Hemifacial Microsomia
- 1997 - 1998 Establishment of a cardiovascular stem cell culture system and its application for gene therapy
- 1997 - 1997 神経堤細胞から血管平滑筋細胞への分化機構の解明
- 1996 - 1997 コンディショナルジーンターゲッティングによる中枢アドレナリン神経の循環調節機能研究
- 1996 - 1997 エンドセリン遺伝子の発生工学的操作による血管形成・リモデリング機構の解明と応用
- 1996 - 1997 Novel methods to avoid difficulties from juvenile lethality or growth retardation in knockout mice and to study circulatory, respiratory, and autonomic functions in them
- 1995 - 1997 心血管系への遺伝子デリバリーシステムの開発と遺伝子治療への応用
- 1996 - 1996 心血管系の発生分化における神経堤細胞の関与と細胞間相互作用機構の解明
- 1995 - 1995 心血管系の発生分化におけるエンドヤリンの意義と関連遺伝子ヒエラルキーの解明
- 1994 - 1995 ESTABLISHMENT OF AN ANIMAL MODEL FOR CONGENITAL CRANIOFACIAL DISEASES BY GENE TARGETING AND DEVELOPMENT OF THEIR GENETIC DIAGNOSIS.
- 1994 - 1995 ESTABLISHMENT OF MICE DEFICTENT IN A VASOACTIVE PEPTIDE BY GENE TARGETING AND THEIR APPLICATION TO PATHOPHYSIOLOGICAL ANALYSIS
- 1994 - 1994 心筋細胞の発生分化及び肥大におけるエンドセリンの意義-エンドセリン遺伝子標的欠損マウスを用いた検討
- 1993 - 1994 Application of gene targeting to the study of atherosclerosis
- 1992 - 1993 Mouse genetics of macrophage scavenger receptors and atherosclerosis
- 1991 - 1992 Intracellular Signaling of Stretch Mediated Myocyte Growth
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Papers (228)：
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Hisanori Matoba, Chifumi Fujii, Kazuaki Maruyama, Masatomo Kawakubo, Masanobu Momose, Kenji Sano, Hitomi Imamura, Hiroki Kurihara, Jun Nakayama. Sirt3 regulates proliferation and progesterone production in Leydig cells via suppression of reactive oxygen species. Endocrinology. 2024
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Yuka Haneda, Sachiko Miyagawa-Tomita, Yasunobu Uchijima, Akiyasu Iwase, Rieko Asai, Takahide Kohro, Youichiro Wada, Hiroki Kurihara. Diverse contribution of amniogenic somatopleural cells to cardiovascular development: With special reference to thyroid vasculature. Developmental dynamics : an official publication of the American Association of Anatomists. 2024. 253. 1. 59-77
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Kazuma Sakai, Tatsuya Hayashi, Yusuke Sakai, Jun Mada, Kazuo Tonami, Yasunobu Uchijima, Hiroki Kurihara, Tetsuji Tokihiro. A three-dimensional model with two-body interactions for endothelial cells in angiogenesis. Scientific Reports. 2023. 13. 1
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Yusuke Watanabe, Yunce Wang, Yuki Tanaka, Akiyasu Iwase, Teruhisa Kawamura, Yumiko Saga, Kenta Yashiro, Hiroki Kurihara, Osamu Nakagawa. Hey2 enhancer activity defines unipotent progenitors for left ventricular cardiomyocytes in juxta-cardiac field of early mouse embryo. Proceedings of the National Academy of Sciences. 2023. 120. 37
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Norika Liu, Naofumi Kawahira, Yasuhiro Nakashima, Haruko Nakano, Akiyasu Iwase, Yasunobu Uchijima, Mei Wang, Sean M. Wu, Susumu Minamisawa, Hiroki Kurihara, et al. Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5. Nature Communications. 2023. 14. 1
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MISC (274)：
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岩瀬 晃康, 内島 泰信, 瀬谷 大貴, 来田 真友子, 東山 大毅, 松居 一悠, 田口 明糸, 山本 尚吾, 福田 史朗, 野村 征太郎, et al. 血管形成・成熟化のシステム生化学 シングルセルマルチオミクスを用いた多細胞連関による心血管システム構築. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [2S04e-03]
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岩瀬晃康, 内島泰信, 瀬谷大貴, 来田真友子, 東山大毅, 松居一悠, 田口明糸, 山本尚吾, 福田史朗, 野村征太郎, et al. シングルセルマルチオミクス及び空間発現情報に基づく心臓神経堤細胞の分化運命決定機構解析. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2023. 128th
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岩瀬晃康, 内島泰信, 瀬谷大貴, 来田真友子, 野村征太郎, 興梠貴英, 宿南知佐, 秋山治彦, 関真秀, 鈴木穣, et al. シングルセルマルチオミクスと空間情報に基づく心臓神経堤細胞の血管/非血管細胞への分化運命決定機構~発生学的起源から病態を考える~. 日本動脈硬化学会総会・学術集会プログラム・抄録集(Web). 2023. 55th
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岩瀬 晃康, 内島 泰信, 瀬谷 大貴, 来田 真友子, 東山 大毅, 松居 一悠, 田口 明糸, 山本 尚吾, 福田 史朗, 野村 征太郎, et al. マルチモーダル情報による心臓内神経堤細胞の分化運命決定メカニズムの解析. 血管. 2022. 45. 1. 41-41
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丸山 和晃, 富田 幸子[宮川], 今中 恭子, 栗原 裕基. 新規リンパ管内皮細胞起源の同定. 日本内分泌学会雑誌. 2022. 97. 5. 1481-1481
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Education (2)：
- 1979 - 1983 The University of Tokyo School of Medicine
- 1977 - 1979 The University of Tokyo School of Arts and Sciences
Professional career (1)：
Work history (11)：
- 2024/04 - 現在 The University of Tokyo Isotope Science Center Project Professor
- 2024/04 - 現在 Kumamoto University International Research Center for Medical Sciences Distinguished Professor
- 2002 - 2024/03 Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo Professor
- 2000 - 2003 Department of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University Professor
- 1991 - 2000 The University of Tokyo Hospital Assistant
- 1992 - 1993 Folk Cardiovascular Institute, Stanford University Postdoctoral fellow
- 1990 - 1991 Japanese Society for the Promotion of Science Research fellow (PD)
- 1987 - 1990 The University of Tokyo Hospital Research resident
- 1987 - Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba Research resident
- 1984 - 1986 Mitsui Memorial Hospital Resident
- 1983 - 1984 The University of Tokyo Hospital Resident
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