2021 - 2024 Development of ammoniated DLC coating for artificial vascular graft and evaluation of influence of ammoniation and cardboxylation on DLC coating
2021 - 2024 Integrated regulatory system by functional sRNA and mRNA-binging protein CsrA
2019 - 2023 Development of periodontal tissue regeneration therapy for horizontal alveolar bone resorption with collagen-binding FGF-2
2018 - 2021 Elucidation of substrate recognition mechanism of bacterial collagenases to develop angiogenic drug seeds
2018 - 2021 腸管スキャフォールドとコラーゲン結合型成長因子を用いた拍動性グラフトの創成
2017 - 2020 Posttranscriptional regulation and mutual regulation of small RNA
2014 - 2017 Structure-function analysis of bacterial toxins in tissue destruction to apply their functional domains to regenerative medicine
2014 - 2017 Mechanism of inducibility of collagenase in Vibrio alginolyticus
2014 - 2017 Development of collagen binding VEGF-C for lymphangiogenesis
2011 - 2014 Preclinical study to elucidate molecular mechanism of matrix anchoring using bacterial proteins
2011 - 2014 Characterization of bacterial collagen sensor and adhesin for screening of new matrix anchors
2014 - Vibrioalginolyticusのコラゲナーゼの転写調節因子の同定とその解析
2012 - Vibrioalginolyticusのコラゲナーゼ産生誘導機構の解明
2012 - Vibriovulnificusのコラゲナーゼ発現誘導機構の解明と新規治療薬への応用
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Papers (28):
I. Putu Bayu Mayura, Kazuyoshi Gotoh, Hayato Nishimura, Erina Nakai, Takehiko Mima, Yumiko Yamamoto, Kenji Yokota, Osamu Matsushita. Elizabethkingia anophelis , an emerging pathogen, inhibits RAW 264.7 macrophage function. Microbiology and Immunology. 2021. 65. 8. 317-324
Chihiro Kageyama, Mayu Sato, Hiroyuki Sakae, Yuka Obayashi, Yoshiro Kawahara, Takehiko Mima, Osamu Matsushita, Kenji Yokota, Motowo Mizuno, Hiroyuki Okada. Increase in antibiotic resistant Helicobacter pylori in a University Hospital in Japan. Infection and drug resistance. 2019. 12. 597-602
Katherine A Rhodes, Nawarat Somprasong, Nicole L Podnecky, Takehiko Mima, Sunisa Chirakul, Herbert P Schweizer. Molecular determinants of Burkholderia pseudomallei BpeEF-OprC efflux pump expression. Microbiology (Reading, England). 2018. 164. 9. 1156-1167
Graft material for nerve regeneration, method for producing graft material for nerve regeneration, and kit for producing graft material for nerve regeneration
Growth factor anchoring type bone graft material, method for producing growth factor anchoring type bone graft material, kit for producing growth factor anchoring type bone graft material, and method for forming bone