Yamaza Takayoshi

ヤマザタカヨシ | Yamaza Takayoshi

Affiliation and department：
Job title： Professor

Research field (1)： Oral medicine

Research keywords (3)：トランスレーショナルリサーチ , 幹細胞 , Stem Cells Translational Research

Research theme for competitive and other funds (37)：

2021 - 2026 乳歯歯髄幹細胞によるヒルシュスプルング病と類縁疾患の病因解明および根治療法の開発
2021 - 2024 Development of a novel treatment for oral cancer using secretory products and cells associated with mesenchymal stem cells
2018 - 2021 Development of liver regenerative therapy using stem cells from human exfoliated deciduous teeth for clinical application
2017 - 2020 Neonatal and pediatric research on liver regenerative medicine using umbilical cord blood
2016 - 2020 Elucidation of the etiology and development of the novel therapy using stem cells from human exfoliated deciduous teeth for Hirschsprung's disease and its allied disorders

2016 - 2019 Elucidation of the novel mechanism to retard the aging by stem cells from human exfoliated deciduous teeth

2015 - 2018 Development of the methods to fabricate a macro-scale liver tissue containinf the bile duct usgin 3D bioprinter

2015 - 2018 The research on creation of new intestinal tract as a treatment for Hirschsprung disease and allied diseases

2015 - 2018 Cell therapy for drug resistance acute rejection after intestinal transplantation

2015 - 2018 Novel Therapy for Allied Disorders of Hirschsprung disease using Stem cells from human exfoliated deciduous teeth.

2015 - 2018 Development of new therapy using stem cells from human exfoliated deciduous teeth for liver failure

2013 - 2016 Development of new therapies for intractable diseases in pediatric surgery using stem cells from human exfoliated deciduous teeth

2013 - 2016 Patient-derived dental pulp stem cell-based innovation for disease mechanism and therapeutic development in cleft lip palate

2013 - 2015 New therapeutic method of Hirschsprung's disease and its variants by using the stem cells from human exfoliated deciduous teeth

2012 - 2015 Development of new therapy for congenital metabolic disorders using functional three-dimensional liver structures constructed by stem cells from human exfoliated deciduous teeth

2012 - 2014 Challenge for SHED-based Hematopoietic Regeneration

2011 - 2013 Acquirement of amelogenic stem/progenitor cells for bio-engineered tooth

2011 - 2012 Liver regeneration using stem cells from hteeth (SHED) for congenital metabol

2009 - 2011 FGF signaling accelerate epithelial regeneration by Oral Epithelial Stem Cells

2009 - 2011 Screening of Gystat i n C binding protein and effect on osteob I asts

2008 - 2010 FGFR2b signaling controls the differentiation and function of Dental Pulp Stem Cells

2004 - 2005 高脂血症治療薬シンバスタチンは骨形成を促進し、骨吸収を抑制するか

2004 - 2005 Effect of neuropeptides on the progression of stress-induced periodontitis

2003 - 2004 破骨細胞におけるシスタチンCの新たな機能(蛋白分解酵素活性抑制以外)はあるか?

2003 - 2004 Oral sensation mechanism of capsaicin

2002 - 2003 上皮幹細胞を用いた自家培養口腔粘膜の短期間で高能率な作製法の開発

2002 - 2003 Effect of stress on the progression of periodontitis

2001 - 2003 Expression and production of proteins containing in hemidesmosme/besement membrane at the interface between the implant-oral epithelium.

2001 - 2002 顎関節炎発症メカニズムの解明

2001 - 2002 災症性骨吸収における破骨細胞でのシグナル伝達経路の解明とその分化・機能変化の解析

2000 - 2001 Analysis of the Expressions and functions of the transcription factor (AP-1) in reparative dentinogenesis

2000 - 2001 MOLECULARBIOLOGICAL STUDY OF NITRIC OXIDE IN THE DEVELOPMENT OF ODONTOBLAST

1999 - 2000 破骨細胞性骨吸収における小胞輸送関連シグナル伝達分子の発現の解析

1999 - 2000 Expression of inducible nitric oxide synthase in rat junctional epithelial cells

1997 - 1998 Analysis of Dentin Matrix Protein Expression in Rat Secondary Odontodlast Differentiation

幹細胞を応用したトランスレーショナルリサーチ

Stem Cells-applied Translational Research

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Papers (95)：

Mohammed Fouad Zakaria, Hiroki Kato, Soichiro Sonoda, Kenichi Kato, Norihisa Uehara, Yukari Kyumoto-Nakamura, Mohammed Majd Sharifa, Liting Yu, Lisha Dai, Haruyoshi Yamaza, et al. NaV1.1 contributes to the cell cycle of human mesenchymal stem cells by regulating AKT and CDK2. Journal of Cell Science. 2024
Mhd Fouad Zakaria, Soichiro Sonoda, Hiroki Kato, Lan Ma, Norihisa Uehara, Yukari Kyumoto-Nakamura, M Majd Sharifa, Liting Yu, Lisha Dai, Erika Yamauchi-Tomoda, et al. Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease. Scientific reports. 2024. 14. 1. 6719-6719
Norihisa Uehara, Shibusawa N, Mikami Y, Kyumoto-Nakamura Y, Sonoda S, Kato H, Yamaza T, Kukita T. Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling. Archives of biochemistry and biophysics. 2023
Koichiro Yoshimaru, Toshiharu Matsuura, Yasuyuki Uchida, Soichiro Sonoda, Shohei Maeda, Keisuke Kajihara, Yuki Kawano, Takeshi Shirai, Yukihiro Toriigahara, Alvin Santoso Kalim, et al. Cutting-edge regenerative therapy for Hirschsprung disease and its allied disorders. Surgery today. 2023
Soichiro Sonoda, Takayoshi Yamaza. Extracellular vesicles rejuvenate the microenvironmental modulating function of recipient tissue-specific mesenchymal stem cells in osteopenia treatment. Frontiers in endocrinology. 2023. 14. 1151429-1151429

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MISC (59)：

吉丸耕一朗, 山座孝義, 梶岡俊一, 高橋良彰, 柳佑典, 松浦俊治, 山座治義, 小田義直, 野中和明, 田口智章. 外科学の新知見(3)再生医療の最前線ヒト脱落乳歯歯髄幹細胞を用いた腸管神経節細胞僅少症に対する腸管神経再生医療. 日本外科学会定期学術集会抄録集. 2018. 118回. 290-290
久本由香里, 上原範久, 久木田明子, 山座孝義, 久木田敏夫. Galectin-9による破骨細胞分化抑制因子MafBの発現制御. Journal of Oral Biosciences Supplement. 2016. 2016. 270-270
張旌旗, 白鳥卓麻, 久木田明子, 山座孝義, 久木田敏夫. 破骨細胞形成過程における細胞融合と細胞質分裂の形態学的解析. Journal of Oral Biosciences Supplement. 2016. 2016. 489-489
田口智章, 柳佑典, 吉丸耕一朗, 松浦俊治, 山座孝義, 山座治義, 野中和明. 肝移植に代わる治療手段としての乳歯歯髄幹細胞移植. 再生医療. 2016. 15
Haiyan Qin, Cunye Qu, Takayoshi Yamaza, Ruili Yang, Xia Lin, Xue-Yan Duan, Kentaro Akiyama, Yi Liu, Qunzhou Zhang, Chider Chen, et al. Ossifying Fibroma Tumor Stem Cells Are Maintained by Epigenetic Regulation of a TSP1/TGF-beta/SMAD3 Autocrine Loop (Retraction of vol 13, pg 577, 2013). CELL STEM CELL. 2015. 16. 5. 569-569

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Education (2)：

1994 - 1998 九州大学大学院歯学研究科
1988 - 1994 Kyushu University School of Dentistry

Professional career (1)：

Ph.D. (Kyushu University)

Work history (7)：

2021/04 - 現在 Kyushu University
2016/04 - 2021/03 Kyushu University Graduate School of Dental Science Associate Professor
2012/10 - 2016/03 Kyushu University Graduate School of Dental Science Assistant Professor
2000/04 - 2010/09 - 九州大学大学院歯学研究院助手
2006/04 - 2009/03 Center for Craniofacial Molecular Cell Biology, University of Southern California

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Association Membership(s) (6)：

日本解剖学会 , 日本顎関節学会 , 日本歯科保存学会 , 日本骨代謝学会 , 日本歯周病学会 , 歯科基礎医学会

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