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J-GLOBAL ID：200901061064463710   Update date: Apr. 12, 2025

NAGAYAMA Kazuaki

ナガヤマ カズアキ | NAGAYAMA Kazuaki
Affiliation and department：
Ibaraki University Graduate School of Science and Engineering (Engineering) Department of Mechanical Engineering

About Ibaraki University Graduate School of Science and Engineering (Engineering) Department of Mechanical Engineering


Job title： Professor
Research field  (7)： Machine materials and mechanics ,  Biomaterials ,  Biomaterials ,  Machine materials and mechanics ,  Biophysics ,  Biomedical engineering ,  Biomedical engineering
Research keywords  (3)： マイクロ・ナノサイエンス ,  細胞骨格、細胞核、DNA ,  バイオメカニクス、メカノバイオロジー、生体医工学、生体材料
Research theme for competitive and other funds  (27)：
  • 2024 - 2027 細胞骨格と核の「繋がり」に基づく生体恒常性維持・破綻メカニズムの解明
  • 2025 - 2026 力学的・幾何学的側面からの細胞機能情報高精度診断プラットフォームの創成
  • 2023 - 2026 Understanding the failure process of soft biological materials - Why does a minor injury lead to fatal tissue damage?
  • 2022 - 2025 生物表面に存在する微細構造の変形と接着/摩擦機能を同時に評価できるシステムの開発
  • 2022 - 2024 Study on the switching mechanism of structural and tensional memory of cells
Show all
Papers (155)：
  • Akiko Saito, Kazuaki Nagayama, Hiroyuki Okada, Shoko Onodera, Natsuko Aida, Takashi Nakamura, Takashi Sawada, Hironori Hojo, Shigeaki Kato, Toshifumi Azuma. Downregulation of Nesprin1 by Runx2 deficiency is critical for the development of skeletal laminopathy-like pathology. Proceedings of the National Academy of Sciences of the United States of America(PNAS). 2025. 122. 15. e2320138122
  • Atsutaka Tamura, Shoma Uehara, Yasuhiro Tanabe, Kazuaki Nagayama. Effect of the cell orientation angle on the nucleus of a cultured vascular smooth muscle cell subjected to uniaxial stretching: A finite element analysis. ASME Journal of Engineering and Science in Medical Diagnostics and Therapy. 2025. 8. 3. 031020
  • Chiho KAMBE, Kazuaki NAGAYAMA. Laser nanodissection for intracellular actin stress fibers and analysis of the severed fiber retraction and regeneration behavior. Transactions of the JSME. 2025. 91. 944. 24-00271
  • Rintaro OTA, Kazuaki NAGAYAMA. Atomic force microscopy estimation of mechanical properties of tunneling nanotubes in cancer cells. Advanced Biomedical Engineering. 2025. 14. 70-78
  • Kazuaki Nagayama, Yuto Hirooka. Changes in the mechanical environment of the nucleus with cell crowding and its effects on DNA damage resistance. Journal of Biosciences and Medicines. 2025. 13. 1. 230-242
ｍore...
MISC (100)：
ｍore...
Books (5)：
  • Vascular Engineering, New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach.
    Springer. 2016 ISBN:9784431548003
  • On the roles of actin stress fibers on the mechanical environment of nucleus in vascular smooth muscle cells, Recent Advances in Mechanobiology.
    Shanghai Scientific and Technological Literature Publishing House (Editor-in-Chief: Shu Chien, Shi Yongde, and Masahiro Sokabe). 2012
  • Effects of cytoskeletal structures on elastic and viscoelastic properities of cells in soft tissues, Biomechanics at Micro- and Nanoscale Levels, Volume IV.
    World Scientific, Singapore. 2007
  • Measurement of Mechanical Properties of Cells Considering Their Intracellular Microstructures, Biomechanics at Micro- and Nanoscale Levels, Volume II.
    World Scientific, Singapore. 2006
  • Microscopic Analysis of Residual Stress and Strain in the Aortic Media Considering Anisotropy of Smooth Muscle Layer, Holzapfel GA, Ogden RW, eds, Mechanics of Biological Tissue.
    Springer-Verlag. 2006
Lectures and oral presentations  (235)：
  • マイクロ矩形溝基板を用いた細胞核拘束による血管平滑筋分化誘導 〜生体材料製微細溝基板への展開〜
    (日本機械学会東北支部 第60期総会・講演会 2025)
  • Study on the Effect of Cell Trapping by Biomaterial Micro Rectangular Groove Substrates on Vascular Smooth Muscle Differentiation
    (2025)
  • Study on the Effects of Microgravity on the Mechanical Structure of Cell and Nuclei
    (2025)
  • Analysis of structural recovery mechanism of actin stress fibers using laser nanosurgery
    (2024)
  • Effects of microgravity on cellular and nuclear mechanical structure
    (2024)
ｍore...
Education (2)：
  • 1996 - 1998 Tohoku University Graduate School, Division of Engineering 機械電子工学専攻
  • 1992 - 1996 Tohoku University Faculty of Engineering 機械知能工学科
Professional career (1)：
  • Ph.D. (Nagoya Institute of Technology)
Work history (7)：
  • 2018/04 - Ibaraki University Department of Mechanical Systems Engineering, Professor
  • 2014/04 - 2018/03 Ibaraki University Department of Intelligent Systems Engineering Professor
  • 2013/04 - 2014/03 Nagoya Institute of Technology Department of Nanomedicine Science, Graduate School of Engineering Associate Professor
  • 2010/04 - 2013/03 Nagoya Institute of Technology Department of Techno-Business Administration, Graduate School of Engineering Associate Professor
  • 2007/04 - 2010/03 Nagoya Institute of Technology Department of Engineering Physics, Electronics and Mechanics, Graduate School of Engineering Assistant Professor
Show all
Committee career (11)：
  • 2021/04 - 現在 日本機械学会 日本機械学会論文集/Transactions of the JSME Mechanical Engineering Journal「生体工学,医工学,スポーツ工学,人間工学 (Bio, Medical, Sports and Human Engineering)」分野アソシエイトエディタ
  • 2021/04 - 2023/03 日本機械学会 バイオエンジニアリング部門・総務委員長
  • 2018/04 - 2020/03 ライフサポート学会 評議員
  • 2018/04 - 2020/03 日本機械学会 バイオエンジニアリング部門・企画委員長
  • 2014/04 - 2019/03 日本機械学会 日本機械学会英文誌 Journal of Biomechanical Science and Engineering編集委員
Show all
Awards (30)：
  • 2024/12 - 日本機械学会関東支部 日本機械学会関東支部2024年度茨城講演会・優秀講演賞【指導学生の受賞】 ホヤ表面ナノ構造の防汚機能メカニズム解明に向けた 摩擦力測定システムの構築(2024年度茨城講演会(2024年8月にて))
  • 2024/12 - 日本機械学会関東支部 日本機械学会関東支部2024年度茨城講演会・優秀講演賞【指導学生の受賞】 がん細胞間の情報伝達を担うナノファイバの 力学特性と機械的役割に関する研究(2024年度茨城講演会(2024年8月にて))
  • 2024/12 - 日本機械学会関東支部 日本機械学会関東支部2024年度茨城講演会・優秀講演賞【指導学生の受賞】 生体組織・細胞の構造支持を司るアクチンストレスファイバの力学特性解析(2024年度茨城講演会(2024年8月にて))
  • 2024/09 - JSMBE Best Research Award 2024 Atomic force microscopy estimation of mechanical properties of tunneling nanotubes in cancer cells
  • 2024/05 - JSME 2023 Journal of Biomechanical Science and Engineering "Graphics of the Year Award" Kazuaki NAGAYAMA, Tatsuya HANZAWA, Akiko SATO: Superficial groove structure in the size of focal adhesion can clarify cell-type-specific differences in force-dependent substrate mechanosensing, Journal of Biomechanical Science and Engineering 18(3): 22-00474, 2023. (https://doi.org/10.1299/jbse.22-00474)
Show all
Association Membership(s) (9)：
日本細胞生物学会 ,  精密工学会 ,  Biophysical Society ,  Biomedical Engineering Society ,  日本生物物理学会 ,  American Physiological Society ,  日本再生医療学会 ,  日本生体医工学会 ,  日本機械学会
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