Rchr
J-GLOBAL ID:200901062103819338
Update date: Dec. 07, 2024 Takashima Hiroshi
タカシマ ヒロシ | Takashima Hiroshi
Affiliation and department: Job title:
processor
Research field (1):
Neurology
Research keywords (3):
分子生物学
, 分子人類遺伝学
, 神経内科学
Research theme for competitive and other funds (24): - 2021 - 2024 超早期治療による発症抑制を目指したHAM発症前炎症病態の診断に資する研究
- 2021 - 2024 Molecular genetic research with a view to treating Charcot-Marie-Tooth disease
- 2018 - 2021 Elucidation of pathology by molecular genetic approach in Charcot-Marie-Tooth disease
- 2016 - 2019 Analysis of pathophysiology of immune-mediated ion channel disease and elucidation of novel antigens
- 2015 - 2018 Overseas research for motor neuron disease with TFG gene mutation
- 2014 - 2017 Analysis of molecular pathology of Charcot-Marie-Tooth disease and search for therapeutic drugs
- 2013 - 2016 analysis of newly target auto antigens in autoimmune encephalitis
- 2013 - 2016 A useful approach for genetic diagnosis of infectious agents using next generation sequencing
- 2012 - 2015 The overseas scientific research for the elucidation of the mechanism of a novel familial motor neuron disease with sensory neuropathy originated in Japan
- 2010 - 2012 molecular genetic analysis of the three hereditary neurodegenerative disorders specifically in Japan
- 2009 - 2011 Pathomechanism of spinocereballar ataxia with axonal neuropathy(SCAN1)-DNA single strand break repair and neurodegeneration
- 2009 - 2011 Study on the development of treatments for collagen VI related myopathy.
- 2009 - 2011 The overseas scientific research for the elucidation of the mechanism of a novel hereditary motor sensory neuropathy originated in Japan
- 2007 - 2008 Pathogenesis of SCAN1, analysis of Tdp1 knockout mice
- 2006 - 2007 アジア人における甲状腺中毒性周期性四肢麻痺の原因遺伝子の同定
- 2006 - 2007 Studies on pathophysiology and experimental therapy of Ullrich's disease and Bethlem myopathy
- 2006 - 2007 Comprehensive genetic analysis by DNA Chip in inherited neuropathies
- 2005 - 2006 Pathomechanisms of DNA repair and neurodegeneration, an analysis of SCAN1 and related disorders.
- 2005 - 2006 Clinical and Genetic studies of autosomal dominant cerebellar ataxia (Miyakonojo type)
- 2005 - 2006 Study for the pathogenesis of neuropathy with Desert hedgehog gene mutation and development for the treatment
- 2004 - 2005 Studies on pathophysiology and experimental therapy of Ullrich's disease with collagen VI deficiency.
- 2004 - 2005 Genetic determination and pathogenesis in thyrotoxic periodic paralysis
- 1994 - Charcot-Marie-Tooth diseaseの分子遺伝学 脊髄小脳変性症、Prion病
- 遺伝性ニューロパチーの分子メカニズム 脊髄小脳変性症の分子遺伝学的研究 遺伝性神経疾患の遺伝学的研究
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Papers (236): -
Takahiro Hobara, Yujiro Higuchi, Mari Yoshida, Masahito Suehara, Masahiro Ando, Jun-Hui Yuan, Akiko Yoshimura, Fumikazu Kojima, Eiji Matsuura, Yuji Okamoto, et al. Genetic and pathophysiological insights from autopsied patient with primary familial brain calcification: novel MYORG variants and astrocytic implications. Acta neuropathologica communications. 2024. 12. 1. 136-136
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Takahiro Hobara, Masahiro Ando, Yujiro Higuchi, Jun-Hui Yuan, Akiko Yoshimura, Fumikazu Kojima, Yutaka Noguchi, Jun Takei, Yu Hiramatsu, Satoshi Nozuma, et al. Linking LRP12 CGG repeat expansion to inherited peripheral neuropathy. Journal of neurology, neurosurgery, and psychiatry. 2024
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Makito Hirano, Motoi Kuwahara, Yuko Yamagishi, Makoto Samukawa, Kanako Fujii, Shoko Yamashita, Masahiro Ando, Nobuyuki Oka, Mamoru Nagano, Taro Matsui, et al. CANVAS-related RFC1 mutations in patients with immune-mediated neuropathy. Scientific reports. 2023. 13. 1. 17801-17801
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Masahiro Ando, Yujiro Higuchi, Jun-Hui Yuan, Akiko Yoshimura, Mika Dozono, Takahiro Hobara, Fumikazu Kojima, Yutaka Noguchi, Mika Takeuchi, Jun Takei, et al. Clinical phenotypic diversity of NOTCH2NLC-related disease in the largest case series of inherited peripheral neuropathy in Japan. Journal of neurology, neurosurgery, and psychiatry. 2023. 94. 8. 622-630
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Satoshi Nozuma, Matsuura E, Tashiro Y, Nagata R, Ando M, Hiramatsu Y, Higuchi Y, Sakiyama Y, Hashiguchi A, Michizono K, et al. Efficacy of l-Arginine treatment in patients with HTLV-1-associated neurological disease. Annals of clinical and translational neurology. 2022
more... MISC (94): -
兒玉大介, 田中正和, 松崎敏男, 松崎敏男, 野妻智嗣, 松浦英治, 高嶋博, 出雲周二, 久保田龍二. HAM診断に適した髄液中抗HTLV-1抗体検査法. 日本神経学会学術大会プログラム・抄録集. 2022. 63rd
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兒玉大介, 田中正和, 松崎敏男, 松崎敏男, 野妻智嗣, 松浦英治, 高嶋博, 出雲周二, 久保田龍二. 抗HTLV-1抗体髄液検査はCLIA法が適している. Neuroinfection (Web). 2022. 27. 2
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児玉大介, 田中正和, 松崎敏男, 松崎敏男, 野妻智嗣, 松浦英治, 高嶋博, 出雲周二, 久保田龍二. 髄液中抗HTLV-1抗体検査とHAM診断. 日本HTLV-1学会学術集会. 2021. 7th
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崎山 佑介, 吉村 明子, 湯地 美佳, 安藤 匡宏, 平松 有, 田代 雄一, 樋口 雄二郎, 荒田 仁, 松浦 英治, 高嶋 博. 神経感染症、新たな時代 次世代シーケンサーを活用した神経感染症のショットガンメタゲノム解析. 臨床神経学. 2020. 60. Suppl. S193-S193
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谷口 雄大, 吉村 明子, 安藤 匡宏, 平松 有, 樋口 雄二郎, 崎山 佑介, 橋口 昭大, 岡本 裕嗣, 松浦 英治, 高嶋 博. 遺伝性末梢神経障害におけるアミロイドポリニューロパチーの臨床像. 臨床神経学. 2020. 60. Suppl. S437-S437
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