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J-GLOBAL ID：200901063351335149 Update date: Dec. 11, 2024

Okuda Katsuhiro

オクダカツヒロ | Okuda Katsuhiro

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Affiliation and department：
Job title： Assistant Professor

Research field (2)： Forensic medicine , Pharmaceuticals - health and biochemistry

Research keywords (9)： Chemical Chaperone , 法中毒 , 法医学 , 神経毒性 , 薬物代謝 , 環境ホルモン , Neurotoxicity , Drug metabolism , EDCs

Research theme for competitive and other funds (12)：

2024 - 2027 新規向精神薬の毒性形成機構の神経科学的解明
2021 - 2024 Orbitrap LC-MS/MSを用いた薬毒物スクリーニングとメタボローム解析
2020 - 2023 Neuroscientific elucidation of the toxic mechanisms of new psychoactive drugs in the brain's reward system
2018 - 2021 Toxicities and pharmacokinetics of new chemical structures of designer drugs, and their prediction in humans
2017 - 2020 Molecular pathology of fatty liver disease learned from the muscle-liver axis

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Papers (67)：

A. Yasuda, W. Murase, A. Kubota, N. Uramaru, K. Okuda, R. Hakota, A. Ikeda, H. Kojima. Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells. Toxicology in Vitro. 2024. 101. 105943
Mihiro Shiga, Masaru Asari, Yuta Takahashi, Shotaro Isozaki, Chisato Hoshina, Kanae Mori, Ryo Namba, Katsuhiro Okuda, Keiko Shimizu. DNA methylation-based age estimation and quantification of the degradation levels of bisulfite-converted DNA. Legal medicine (Tokyo, Japan). 2024. 67. 102336-102336
森香苗, 奥田勝博, 浅利優, 高橋悠太, 難波亮, 清水惠子. アルコール感受性遺伝子型を考慮した血中アルコール濃度推定による事件遭遇時の被害者の行動能力. 法医学の実際と研究. 2023. 66. 147-151
Yuta Takahashi, Masaru Asari, Shotaro Isozaki, Chisato Hoshina, Katsuhiro Okuda, Kanae Mori, Ryo Namba, Wataru Ochiai, Keiko Shimizu. Age prediction by methylation analysis of small amounts of DNA using locked nucleic acids. Journal of forensic sciences. 2023. 68. 1. 267-274
Katsuhiro Okuda, Shotaro Isozaki, Masaru Asari, Hiroki Tanaka, Kie Horioka, Yuta Takahashi, Chisato Hoshina, Hiromi Yamada, Kanae Mori, Ryo Namba, et al. Multidirectional analysis for a colchicine poisoning case revealed detail cause of death and its mechanism. Legal medicine (Tokyo, Japan). 2022. 58. 102092-102092

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MISC (5)：

Seigo Sanoh, Naoki Takaoka, Katsuhiro Okuda, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Mami Kurosaki, Mineko Terao, Enrico Garattini, Shigeru Ohta. INHIBITORY EFFECTS OF DRUGS ON THE METABOLIC ACTIVITIES OF MOUSE AND HUMAN ALDEHYDE OXIDASE ISOFORMS. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S83-S83
Yaichiro Kotake, Midori Isomura, Kyoichi Masuda, Masatsugu Miyara, Katsuhiro Okuda, Shigeyoshi Samizo, Seigo Sanoh, Toru Hosoi, Koichiro Ozawa, Shigeru Ohta. Tributyltin-induced endoplasmic reticulum stress and its mechanism. TOXICOLOGY LETTERS. 2013. 221. S173-S173
OKUDA K. Neuroprotective or neurotoxic activity of 1-methy1-1, 2, 3, 4-tetrahydroisoquinoline and related compounds. Bioorganic Medicinal Chemistry Letters. 2003. 13. 17. 2853-2855
K Okuda, Y Kotake, R Taguchi, S Ohta. Effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline, a parkinsonism preventing substance, and its analogues on cultured neuronal cells. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2002. 17. S153-S153
K Okuda, Y Kotake, S Ohta. Determination method of 1-methyl-1,2,3, 4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay. LIFE SCIENCES. 2002. 70. 24. 2871-2883

Books (1)：

頸椎骨折 Autopsy imaging 症例集第2巻
ベクトル・コア 2018

Lectures and oral presentations (196)：

薬毒物試験法と注解改訂に向けた検討 -II-1 有害性ガス試験法(1・2・3 血液中、尿中のチオ硫酸)の改訂(新規試験法)-
(日本薬学会第144年会)
知床観光船沈没事故における検案の実情報告
(第29回日本災害学会総会学術集会)
Evaluation of the effects on the dopaminergic reward system and the blood-brain barrier permeability of diphenidine derivatives using rat brain microdialysis
(Neuroscience 2023)
法医学における薬学出身者の役割と現状
(フォーラム2023 衛生薬学・環境トキシコロジー)
死因診断マーカーの発見を目的としたメタボローム解析法の構築
(日本法中毒学会第42年会)

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Education (3)：

- 2004 Hiroshima University Graduate School, Division of Medical Sciences
- 2004 Hiroshima University
- 1999 Hiroshima University Faculty of Medicine Institute of Pharmaceutical Sciences

Professional career (1)：

博士(薬学) (広島大学)

Work history (6)：

2014/04 - 現在 Asahikawa Medical College Assistant Professor
2012/04 - 2014/03 Hiroshima University Research Assistant
2011/01 - 2012/03 Kyushu University Researcher
2010/02 - 2010/10 テンプル大学心臓血管研究センター研究員
2007/04 - 2010/01 Hiroshima International University Assistant Professor

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Association Membership(s) (10)：

日本法医病理学会 , 日本中毒学会 , 日本犯罪学会 , Japanese Association of Forensic Science and Technology , 日本法医学会 , 日本法中毒学会 , 日本薬学会 , 日本神経化学会 , Japanese Society for Neurochemistry , The Pharmaceutical Society of Japan

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