Yanai Hikaru

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://tupls-matsumotoken.jimdofree.com/

Research field (3)： Pharmaceuticals - chemistry and drug development , Synthetic organic chemistry , Structural/physical organic chemistry

Research keywords (4)： Physical Organic Chemistry , Organofluorine Chemistry , Synthetic Organic Chemistry , Acid Catalysis

Research theme for competitive and other funds (19)：

2023 - 2026 Improvement of cell membrane permeability by fluorineted carbanion substitutents
2023 - 2026 Development of functional molecules bearing stable carbanion moieties
2020 - 2023 Development of novel cascade reactions for polysubstituted polycyclic aromatics
2022 - Development of novel fluorinated substituents deirected to medicinal chemistry
2019 - 2020 蛍光色素の水溶性と脂溶性を制御する新手法の開発

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Papers (79)：

S. Hoshikawa, J. M. Alonso, T. Matsumoto, H. Yanai, P. Almendros. Gold-catalyzed orthogonal and chemocontrolled synthesis of [4-7-6] tricycles from 1,5-diynes. Advanced Synthesis & Catalysis. 2024. 366. accepted
T. Kawazoe, H. Yanai, T. Fukuhara, Y. Kanatani, A. Imakhlaf, B. Witulski, T. Matsumoto. Ring rearrangement reactions of 4-alkenylisocoumarins and photophysical evaluation of multi-substituted anthracene products. Chemistry - A European Journal. 2024. 30. e202401965
M. Ghashghaee, B. Kaboudin, F. Kazemi, M. Hassan, H. Fukaya, H. Yanai. Synthesis of 6H-chromeno[4,3-b]quinolin-7- ylphosphonates through three component phosphonylation of coumarin carbaldehyde and their antimicrobial and photophysical properties. The Journal of Organic Chemistry. 2024. 89. 11. 7662-7670
H. Yanai, S. Kurogi, S. Hoshikawa, T. Matsumoto. HFIP-mediated desulfinative Friedel-Crafts cyclobutenylation reaction. Chemistry - A European Journal. 2024. 30. e202400843
B. Kaboudin, H. Esfandiari, M. Kakavand, M. Sohrabi, E. Yousefian Amirkhiz, A. Nesha, T. Kawazoe, H. Fukaya, H. Yanai. Phosphite-imidazole catalyzed N-formylation and N-acylation of amines. Organic & Biomolecular Chemistry. 2023. 21. 40. 8182-8189

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MISC (7)：

H. Yanai. Hirshfeld Atom Refinement. Yuki Gosei Kagaku Kyokaishi. 2022. 80. 3. 281-281
Hikaru Yanai. Development of novel synthetic reactions though specific properties of fluorine and fluorine-containing substituents. Chemical Industry. 2019. 70. 8. 8-14
矢内光. 連続反応を活用した多置換多環式芳香族化合物の合成. 上原記念生命科学財団研究報告集. 2018. 32. 108
Yanai, H. Synthesis of carbanion-containing salts and their applications as novel organocatalysts. Chemical Industry. 2017. 68. 9. 73-78
Yanai, H. Superacidic carbon acids: Synthesis and catalysis. Fine Chemicals. 2017. 46. 3. 21-28

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Patents (5)：

光学活性なフルオロアルケン誘導体およびその製造方法
Preparation of bis(trifluoromethylsulfonyl)methyl compounds and their use as acid catalysts
Preparation of bis(trifluoromethanesulfonyl)ethyl-bearing phenolic compounds as acid catalysts, and method for preparing same
Preparation of α-aminodifluoromethylene compounds
Preparation of fluorine-containing quinolines from 2-vinylanilines via fluorine-containing dihydroquinolines

Books (7)：

Green Synthetic Approaches for Biologically Relevant Heterocycles (Second Edition), Volume 2: Green Catalytic Systems and Solvents; G. Brahmachari (Ed.)
Elsevier 2021 ISBN:9780128207925
Development of Organocatalysts and Their Application to Industry; T. Akiyama (Ed.)
CMC Publishing 2018 ISBN:9784781313238
フッ素化学入門2015
三共出版 2015 ISBN:9784782707272
Green Synthetic Approaches for Biologically Relevant Heterocycles; G. Brahmachari (Ed.)
Elsevier: Amsterdam 2014 ISBN:9780128000700
パートナー薬品製造学改訂第2版,野上靖純,田口武夫,長普子(編集)
南江堂 2012 ISBN:4524402942

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Lectures and oral presentations (85)：

Controlling the solubility profiles of polycyclic aromatic compounds by carbanionic substituents
(International Congress on Pure & Applied Chemistry (ICPAC) Bali 2023, Bali, Indonesia)
Fluorinated stable carbanions as substituents for controlling the solubility profiles of organic compounds
(23rd International Symposium on Fluorine Chemistry, Québec City, Canada 2023)
HFIP-mediated detriflylative allylic substitution reactions on the cyclobutene platform
(23rd International Symposium on Fluorine Chemistry, Québec City, Canada 2023)
The fluorine magic in drug discovery
(Departmental seminar at Toyohashi University of Technology 2022)
Ring-rearrangement strategy for selective synthesis of pseudo aromatic polyketides
(International Congress on Pure & Applied Chemistry (ICPAC), Kota Kinabalu, Malaysia 2022)

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Education (2)：

2002 - 2005 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmaceutical Sciences
1998 - 2002 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Division of Pharmaceutical Sciences

Professional career (1)：

Doctor of Philosophy (Tokyo University of Pharmacy and Life Science)

Work history (7)：

2016/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Associate Professor
2013/04 - 現在 Tokyo University of Agriculture and Technology Lecturer (part-time)
2018/09 - 2018/10 Université Caen-Normandie Invited Professor
2014/07 - 2016/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Senior Lecturer
2008/09 - 2014/06 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Assistant Professor

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Committee career (9)：

2023/08 - 現在日本フッ素化学会産学連携部会学界会員
2023/08 - 現在有機合成化学協会第40回有機合成化学セミナー実行委員
2023/05 - 現在日本フッ素化学会企画委員
2023/03 - 現在 The Society of Synthetic Organic Chemistry, Japan Editorial Board of J. Synth. Org. Chem., Jpn.
2020 - 現在 The Society of Fluorine Chemistry, Japan Editorial Board of "Fluorine"

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Awards (6)：

2015/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award for Young Scientists
2013/12 - The Society of Synthetic Organic Chemistry, Japan Mitsubishi Gas Chemical Company Award in Synthetic Organic Chemistry, Japan
2012/03 - Tokyo University of Pharmacy and Life Sciences Nakako Yoshida Research Award
2011/08 - 日本フッ素化学会第1回フッ素化学若手の会優秀ポスター賞
2010/10 - 日本フッ素化学会第34回フッ素化学討論会最優秀ポスター賞

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Association Membership(s) (5)：

THE CHEMICAL SOCIETY OF JAPAN , American Chemical Society , 日本フッ素化学会 , The Society of Synthetic Organic Chemistry, Japan , The Pharmaceutical Society of Japan

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