Rchr
J-GLOBAL ID:200901064221410498
Update date: Mar. 16, 2025 Yanai Hikaru
Yanai Hikaru
Affiliation and department: Job title:
Associate Professor
Homepage URL (1): https://tupls-matsumotoken.jimdofree.com/ Research field (3):
Pharmaceuticals - chemistry and drug development
, Synthetic organic chemistry
, Structural/physical organic chemistry
Research keywords (4):
Physical Organic Chemistry
, Organofluorine Chemistry
, Synthetic Organic Chemistry
, Acid Catalysis
Research theme for competitive and other funds (19): - 2023 - 2026 Improvement of cell membrane permeability by fluorineted carbanion substitutents
- 2023 - 2026 Development of functional molecules bearing stable carbanion moieties
- 2020 - 2023 Development of novel cascade reactions for polysubstituted polycyclic aromatics
- 2022 - Development of novel fluorinated substituents deirected to medicinal chemistry
- 2019 - 2020 蛍光色素の水溶性と脂溶性を制御する新手法の開発
- 2017 - 2020 Structural chemistry on highly stabilized carbanions
- 2015 - 2019 強酸性炭素酸とその共役塩基に着目した新触媒の開発
- 2017 - 2018 連続反応を活用した多置換多環式芳香族化合物の合成
- 2015 - 2017 高度に分極したアルケンの構造と反応性に立脚した触媒作用の探求
- 2014 - 2017 Novel cascade reactions triggered by silyl acetal activation
- 2014 - 2016 Development of strongly acidic organocatalysts
- 2015 - 2016 新しい酸性官能基の開発と触媒作用の探求
- 2012 - 2014 Development of novel acidic functionality directed to design of organocatalysts
- 2012 - 2014 Development of superacidic carbon acids: synthesis, characterization, and catalyst activity
- 2010 - 2012 Development of new synthetic reactions based on novel acid catalysts
- 2011 - 2011 ビス(トリフルオロメチルスルホニル)メチル基を有する高活性酸触媒の開発
- 2008 - 2010 Preparation of functionalized organofluorine compounds toward drug discovery
- 2007 - 2009 Development of functional molecules on the basis of design of novel Lewis acid catalysts
- 2005 - 2007 Development of synthetic methodogies for organofluorine compounds in medicinal chemistry
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Papers (84): -
H. Yanai, R. Sano, S. Hoshikawa, T. Matsumoto. Solvent effects in the reactions of alkenes with gem-bis(triflyl)ethylene. Asian Journal of Organic Chemistry. 2025. 14. 3. e202400651
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R. Kakuchi, T. Oguchi, M. Kuroiwa, Y. Hirashima, M. Omichi, N. Seko, H. Yanai. Installation of superacidic carbon acid moieties into polymer materials via post-polymerization modification. Chemical Science. 2024. 15. 46. 19322-19327
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H. Yanai, S. Hoshikawa, H. Watanabe, H. Kaneko, H. Nakaminami, T. Matsumoto. Recyclable 2-fluoropyridine derivative as a storage for highly electrophilic 1,1-bis(triflyl)ethylene. Chemical and Pharmaceutical Bulletin. 2024. 72. 10. 884-889
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T. Martínez del Campo, D. San Martín, L. Gamarra, E. Cerrón, S. Cembellín, H. Yanai, P. Almendros. Indium-mediated preparation of bis(α-hydroxyallenes) or α,α’-dihydroxyallenynes and further gold-catalyzed cyclizations. The Journal of Organic Chemistry. 2024. 89. 19. 14228-14232
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S. Hoshikawa, J. M. Alonso, T. Matsumoto, H. Yanai, P. Almendros. Gold-catalyzed orthogonal and chemocontrolled synthesis of [4-7-6] tricycles from 1,5-diynes. Advanced Synthesis & Catalysis. 2024. 366. 17. 3683-3688
more... MISC (7): -
H. Yanai. Hirshfeld Atom Refinement. Yuki Gosei Kagaku Kyokaishi. 2022. 80. 3. 281-281
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Hikaru Yanai. Development of novel synthetic reactions though specific properties of fluorine and fluorine-containing substituents. Chemical Industry. 2019. 70. 8. 8-14
- 矢内 光. 連続反応を活用した多置換多環式芳香族化合物の合成. 上原記念生命科学財団研究報告集. 2018. 32. 108
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Yanai, H. Synthesis of carbanion-containing salts and their applications as novel organocatalysts. Chemical Industry. 2017. 68. 9. 73-78
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Yanai, H. Superacidic carbon acids: Synthesis and catalysis. Fine Chemicals. 2017. 46. 3. 21-28
more... Patents (5): Books (9): - Isocoumarins in skeletal editing: A synthetic approach to multi-substituted polycyclic aromatics
Società Chimica Italiana. 2025 ISBN:9788894952520
- 高度に求電子的な1,1-ビス(トリフリル)エチレンの合成化学的活用
シーエムシー出版 2025 ISBN:9784781318585
- Green and catalytic methods for γ-lactone synthesis
Elsevier 2021 ISBN:9780128207925
- Molecular Transformations Mediated by Superacidic Carbon Acids
CMC Publishing 2018 ISBN:9784781313238
- フッ素化学入門2015
三共出版 2015 ISBN:9784782707272
more... Lectures and oral presentations (86): -
The latent nucleophilicity of carbanions stabilized by (trifluoromethyl)sulfonyl group
(24th International Symposium on Fluorine Chemistry, Shanghai, China 2024)
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Controlling the solubility profiles of polycyclic aromatic compounds by carbanionic substituents
(International Congress on Pure & Applied Chemistry (ICPAC) Bali 2023, Bali, Indonesia 2023)
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Fluorinated stable carbanions as substituents for controlling the solubility profiles of organic compounds
(23rd International Symposium on Fluorine Chemistry, Québec City, Canada 2023)
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HFIP-mediated detriflylative allylic substitution reactions on the cyclobutene platform
(23rd International Symposium on Fluorine Chemistry, Québec City, Canada 2023)
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The fluorine magic in drug discovery
(Departmental seminar at Toyohashi University of Technology 2022)
more... Education (2): - 2002 - 2005 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmaceutical Sciences
- 1998 - 2002 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Division of Pharmaceutical Sciences
Professional career (1): - Doctor of Philosophy (Tokyo University of Pharmacy and Life Science)
Work history (7): - 2016/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Associate Professor
- 2013/04 - 現在 Tokyo University of Agriculture and Technology Lecturer (part-time)
- 2018/09 - 2018/10 Université Caen-Normandie Invited Professor
- 2014/07 - 2016/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Senior Lecturer
- 2008/09 - 2014/06 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Assistant Professor
- 2013/10 - 2013/12 Université Claude Bernard Lyon 1-CNRS Visiting Researcher
- 2005/04 - 2008/07 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Research Assistant
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Committee career (10): - 2025/04 - 現在 The Pharmaceutical Society of Japan Delegate
- 2023/08 - 現在 The Society of Fluorine Chemistry, Japan Committee Member for Industry-Academia Collaboration
- 2023/05 - 現在 The Society of Fluorine Chemistry, Japan Committee Member of The Fluorine Chemistry Seminar
- 2023/03 - 現在 The Society of Synthetic Organic Chemistry, Japan Editorial Board Member of <i>J. Synth. Org. Chem., Jpn.</i>
- 2020 - 現在 The Society of Fluorine Chemistry, Japan Editorial Board Member of <i>Fluorine</i>
- 2023/08 - 2024/12 The Society of Synthetic Organic Chemistry, Japan Committee Member of The 40th Seminar on Synthetic Organic Chemistry
- 2022 - 2023 The Society of Synthetic Organic Chemistry, Japan Committee Chair of The Fluorine Chemistry Young Researchers’ Conference
- 2008 - 2015 The Pharmaceutical Society of Japan, Division of Organic Chemistry Committee Member of The Symposium on Organic Chemistry: the Next Generation
- 2010 - 2011 The Society of Fluorine Chemistry, Japan Committee Member of The Fluorine Chemistry Young Researchers’ Conference
- 2009 - 2010 日本薬学会 第3回日本薬学会関東支部若手シンポジウム実行委員
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Awards (4): - 2015/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award for Young Scientists
- 2013/12 - The Society of Synthetic Organic Chemistry, Japan Mitsubishi Gas Chemical Company Award in Synthetic Organic Chemistry, Japan
- 2012/03 - Tokyo University of Pharmacy and Life Sciences Nakako Yoshida Research Award
- 2010/02 - Research Foundation ITSUU Laboratory Fluorine Chemistry Research Incentive Award
Association Membership(s) (5):
THE CHEMICAL SOCIETY OF JAPAN
, American Chemical Society
, 日本フッ素化学会
, The Society of Synthetic Organic Chemistry, Japan
, The Pharmaceutical Society of Japan
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