Rchr

J-GLOBAL ID：200901065417083491 Update date: Aug. 11, 2024

Nakamura Hiroaki

ナカムラヒロアキ | Nakamura Hiroaki

Affiliation and department：
Job title： professor

Research field (1)： Oral medicine

Research keywords (4)：歯の発生 , 骨リモデリング , tooth development , bone remodeling

Research theme for competitive and other funds (52)：

2023 - 2026 歯槽骨再生を促進する副甲状腺ホルモン・ビスホスホネート併用療法の開発
2021 - 2024 副甲状腺ホルモン関連タンパクの歯槽骨再生における役割の解明と再生歯科治療への応用
2020 - 2023 マクロファージ由来骨再生因子の同定と歯槽骨再生医療への応用
2019 - 2022 Establishment of a new method for analyzing bone remodeling mechanisms using genetically modified amphibians
2018 - 2021 Functional role of cell migration factor LRP1 in periodontal tissue repair

2017 - 2020 組織マクロファージによる歯髄微小環境調節機構の解明と歯髄組織再生療法の開発

2016 - 2019 The effects of CC25 on bone formation in new born mouse

2016 - 2019 Roles Gli1-positive dental pulp stem cells during dentin regeneration

2016 - 2019 Elucidation of the osteoclast-derived cytokine-Wnt signaling network responsible for coupling between bone resorption and formation.

2015 - 2018 Functional roles of RhoT1 on repair of periodontal tissue

2015 - 2017 M2マクロファージの修復象牙質形成への関与と新規歯髄再生療法の開発

2013 - 2016 Elucidation of Wnt signaling network controlling bone metabolism

2012 - 2015 Comprehensive analysis of the relationship between the function of ABC transporters and bone metabolism; from the view point of osteoclast generation and function

2012 - 2015 The effect of SUMOylation on bone formation in mouse

2012 - 2015 Regulations of bone metabolism by bovine- and neutrophil-derived lactoferrin

2012 - 2015 Functional analysis of Osterix in immature odontoblasts for cell differentiation

2013 - 2014 骨代謝共役を担うWntシグナルの解明

2011 - 2013 骨原性細胞の誘導による再生治療の試み

2010 - 2012 Analysis of osteoclast niche regulated by Wnt signals.

2009 - 2011 歯根膜組織幹細胞の誘導と再生歯科医療の可能性

2008 - 2010 Microenvironment of stem cells in bone formation

2008 - 2010 Analysis of molecular mechanism of carbon nanotube regulating bone metabolism

2008 - 2009 歯槽骨の再生・維持に関する基礎的研究

2007 - 2008 Elucidation of the regulated mechanism of bone metabolism by osteoclastic transcytosis.

2006 - 2008 Elucidation of the mechanism of enhancement of ectopic bone formation in osteopetrotic mice.

2006 - 2007 Roles of Hypoxia and the Trantscription Factor Hypoxia-Inducible Factor-lalpha(HIF-lalpha) in the Development and Progression of Bone Metastases of Breast Cancer

2006 - 2007 An attempt the tooth embryogenesis combined with embryonic stem cells and tooth mesenchymal stem cells that originated from neural crest

2006 - 2007 The relationship between cell proliferation and RANKL-induced osteoclastogenesis

2005 - 2006 BMP antagonist調節による歯および骨の再生

2005 - 2006 Elucidation of molecular mechanism of alveolar bone remodeling induced by orthodontic force.

2005 - 2006 Establishment of periodontitis treatment method by inhibition of RANK-Toll like receptor signal

2003 - 2004 エナメル芽細胞内情報伝達系に関する形態学的解析

2003 - 2004 THE EVALUATION OF OSTEOGEMC POTENTIAL OF CULTURED PERIOSTEUM-DERIVED CELLS

2003 - 2004 Cell biological analysis of extracellular-signal regulated kinase (ERK) in the differentiation of ameloblasts

2001 - 2002 骨改造現象におけるオステオプロテジェリン発現、骨基質局在調節機構の解明

1999 - 2000 エナメル質形成におけるCD44を介した細胞内情報伝達機構の解析

1999 - 2000 Reasearch for control system of bone morphogy adapted to ageing or environment

1999 - 1999 エネルギー損失分光電子顕微鏡を用いた組織細胞化学による石灰化研究の新しい展開

1996 - 1998 Morphological and molecular cell biology studies on aging changes and reconstruction of bone tissue.

1996 - 1997 骨形成蛋白(BMP-2)の生涯的役割-個体発生から老化まで-

1996 - 1996 エナメル器細胞の分化とCD44,ERMファミリー発現に関する研究

1995 - 1995 軟骨内骨化過程での血管および血管周囲細胞の機能に関する免疫組織化学的研究

1994 - 1995 Development of microscopic image processing system.

1994 - 1995 Cell biological studies of hard tissue using three dimensional morphometry.

1994 - 1994 エナメル器細胞の分化とヘパラン硫酸鎖,CD44発現に関する研究

1993 - 1993 エナメル器のヘパラン硫酸プロテオグリカン局在と成長因子に関する免疫組織化学的研究

1992 - 1993 Histological cna histochenmical studies on the bone metabolism using g confocal laser scanning microscope.

1992 - 1992 エナメル器におけるヘパラン硫酸プロテオグリカン局在に関する免疫組織細胞化学的研究

1991 - 1991 エナメル芽細胞の分化と複合糖質に関する研究-レクチン組織細胞化学的研究-

1990 - 1991 Cell biological studies on cell-cell, cell-matrix interaction in bone metabolism.

Mechanism of tooth developmet

Cell-cell and cell- matrix interaction in bone remodeling

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Papers (151)：

Yuri Seki, Hiroaki Takebe, Yuya Nakao, Kohei Sato, Toshihide Mizoguchi, Hiroaki Nakamura, Masahiro Iijima, Akihiro Hosoya. Osteoblast differentiation of Gli1+ cells via Wnt and BMP signaling pathways during orthodontic tooth movement. Journal of oral biosciences. 2024
Saki Fujii, Hiroaki Takebe, Toshihide Mizoguchi, Hiroaki Nakamura, Tsuyoshi Shimo, Akihiro Hosoya. Bone formation ability of Gli1+ cells in the periodontal ligament after tooth extraction. Bone. 2023. 116786-116786
Yuri Seki, Hiroaki Takebe, Toshihide Mizoguchi, Hiroaki Nakamura, Masahiro Iijima, Kazuharu Irie, Akihiro Hosoya. Differentiation ability of Gli1+ cells during orthodontic tooth movement. Bone. 2022. 116609-116609
N Shalehin, Y Seki, H Takebe, S Fujii, T Mizoguchi, H Nakamura, N Yoshiba, K Yoshiba, M Iijima, T Shimo, et al. Gli1+-PDL Cells Contribute to Alveolar Bone Homeostasis and Regeneration. Journal of dental research. 2022. 220345221106921-220345221106921
Miroku Hara, Kanji Horibe, Hiroshi Mori, Hiroaki Nakamura. The role of canonical Wnt signaling in dentin bridge formation. Journal of Oral Biosciences. 2021. 63. 2. 199-209

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MISC (146)：

吉羽永子, 大倉直人, 前川知樹, 泉健次, 細矢明宏, 中村浩彰, 前田健康, 野杁由一郎, 吉羽邦彦. ヒト歯髄においてシュワン細胞はマクロファージをM2型へ転換する. Journal of Oral Biosciences Supplement (Web). 2019. 2019
田所治, 奥村雅代, 前田信吾, 前田信吾, 金銅英二, 矢ヶ崎裕, 堀部寛治, 中村浩彰. 心臓の位置と大動脈の異常を伴った胸管の破格例. 日本解剖学会総会・全国学術集会講演プログラム・抄録集. 2018. 123rd
Toru Hiraga, Hiroaki Nakamura. Functional Comparison between CD44s and CD44v8-10 in Cancer Metastasis to Bone. JOURNAL OF BONE AND MINERAL RESEARCH. 2017. 32. S312-S312
吉羽永子, 大倉直人, 細矢明宏, 中村浩彰, 野杁由一郎, 吉羽邦彦, 枝並直樹, 遠間愛子, 竹内亮介. ヒト歯髄組織創傷治癒過程における骨髄由来間葉系前駆細胞fibrocyteの動態検索. Journal of Oral Biosciences Supplement. 2017. 2017. 427-427
吉羽永子, 大倉直人, 細矢明宏, 中村浩彰, 野杁由一郎, 吉羽邦彦. ヒト歯髄組織創傷治癒過程における骨髄由来間葉系前駆細胞fibrocyteの動態検索. Journal of Oral Biosciences Supplement (Web). 2017. 2017

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Books (8)：

歯科国試パーフェクトマスター口腔組織・発生学
医歯薬出版 2017
新骨の科学第2版
医歯薬出版 2016
口腔組織・発生学第2版
医歯薬出版 2015
新骨の科学
医歯薬出版 2007 ISBN:9784263456095
硬組織研究ハンドブック
松本歯科大学出版会 2005 ISBN:4944171129

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Professional career (1)：

(BLANK) (Niigata University)

Work history (12)：

2004 - 2004 Matsumoto Dental University Institute for Oral Science
2004 - 2004 Professor, Matsumoto Dental University, Institute for Oral Science
1999 - 2004 Okayama University Dental School
1999 - 2004 Associate Professor, Okayama Univ. Dental School,
2004 - - 松本歯科大学口腔解剖学第二講座教授

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Association Membership(s) (5)：

アメリカ骨代謝学会(The American Society for Bone and Mineral Research) , 新潟歯学会 , 歯科基礎医学会 , 日本骨代謝学会 , 日本解剖学会

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