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J-GLOBAL ID：200901065541220596 Update date: Nov. 12, 2024

Araki Wataru

アラキワタル | Araki Wataru

Affiliation and department：
Job title： Adjunct lecturer

Research field (2)： Neurology , Neuroscience - general

Research keywords (2)：認知症 , Dementia

Research theme for competitive and other funds (10)：

2019 - 2022 Elucidation of the synapse pathology of Alzheimer's disease with a focus on the receptors which bind amyloid-beta oligomers
2016 - 2019 Molecular mechanisms of BACE1 dysregulation and synaptic degeneration in Alzheimer's disease
2013 - 2016 Elucidation of the pathological upregulation of beta-secretase and its molecular regulation
2010 - 2012 A study toward development of novel Alzheimer therapies based on the regulation ofβ-secretase function
2007 - 2008 Elucidation of the regulation mechanisms of activity, expression and cellular localization of β-secretase in neuronal cells

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Papers (69)：

Wataru Araki. Aβ Oligomer Toxicity-Reducing Therapy for the Prevention of Alzheimer’s Disease: Importance of the Nrf2 and PPARγ Pathways. Cells. 2023
Akiko Amano, Nobuo Sanjo, Wataru Araki, Yasutaka Anraku, Makoto Nakakido, Etsuro Matsubara, Takami Tomiyama, Tetsuya Nagata, Kouhei Tsumoto, Kazunori Kataoka, et al. Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain. Journal of nanobiotechnology. 2023. 21. 1. 36-36
Wataru Araki. Amyloid-β oligomers interact with NMDA receptors containing GluN2B subunits and metabotropic glutamate receptor 1 in primary cortical neurons: Relevance to the synapse pathology of Alzheimer's disease. Neuroscience research. 2022
Wataru Araki, Fuyuki Kametani. Protection against Amyloid-β Oligomer Neurotoxicity by Small Molecules with Antioxidative Properties: Potential for the Prevention of Alzheimer’s Disease Dementia. Antioxidants. 2022. 11. 1. 132-132
Keisuke Komaki, Tetsuya Takano, Yutaka Sato, Akiko Asada, Shikito Ikeda, Kaoru Yamada, Ran Wei, Anni Huo, Aoi Fukuchi, Taro Saito, et al. Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1. Journal of biochemistry. 2022. 170. 6. 729-738

MISC (2)：

Wataru Araki. Reversibility of A beta oligomer neurotoxicity. ONCOTARGET. 2017. 8. 31. 50335-50336
W ARAKI, N KITAGUCHI, Y TOKUSHIMA, K ISHII, H ARATAKE, S SHIMOHAMA, S NAKAMURA, J KIMURA. TROPHIC EFFECT OF BETA-AMYLOID PRECURSOR PROTEIN ON CEREBRAL CORTICAL-NEURONS IN CULTURE. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1991. 181. 1. 265-271

Professional career (1)：

Work history (3)：

2019/04 - 現在 Tokyo Medical and Dental University Department of Neurology and Neurological Science Adjunct lecturer
2010/04 - 2019/03 National Institute of Neuroscience, NCNP Section chief
1998/04 - 2010/03 National Institute of Neuroscience, NCNP Section chief

Association Membership(s) (4)：

日本認知症学会 , 日本分子生物学会 , 日本内科学会 , 日本神経学会

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