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J-GLOBAL ID：200901065718689565 Update date: Feb. 25, 2025

Sakai Akiko

サカイアキコ | Sakai Akiko

Affiliation and department：

Research field (2)： Medical biochemistry , Functional biochemistry

Research keywords (2)：抗がん剤耐性 , プロテオーム

Research theme for competitive and other funds (12)：

2017 - 2022 抗癌剤耐性関連タンパク質HSPB1の構造機能相関の解明とその臨床応用
2014 - 2018 Elucidation of structure-function relationship of HSPB1 in anticancer drug resistance mechanism
2013 - 2017 Proteomic analysis of chemotherapy resistance related proteins in human breast cancer cells
2012 - 2015 Elucidation and application of the 5FU resistant mechanism of breast cancer using proteomic analysis
2011 - 2015 Studies on the molecular mechanism of 5-fluorouracil response proteins using a proteomic approach

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Papers (37)：

Yasuhiro Machida, Takeshi Murakawa, Akiko Sakai, Mitsuo Shoji, Yasuteru Shigeta, Hideyuki Hayashi. Reaction of threonine synthase with the substrate analogue 2-amino-5-phosphonopentanoate: implications into the proton transfer at the active site. The Journal of Biochemistry. 2020. 167. 4. 357-364
Hiroya Fujioka, Akiko Sakai, Satoru Tanaka, Kosei Kimura, Akiko Miyamoto, Mitsuhiko Iwamoto, Kazuhisa Uchiyama. Comparative proteomic analysis of paclitaxel resistance-related proteins in human breast cancer cell lines. ONCOLOGY LETTERS. 2017. 13. 1. 289-295
Shoko Edogawa, Akiko Sakai, Takuya Inoue, Satoshi Harada, Toshihisa Takeuchi, Eiji Umegaki, Hideyuki Hayashi, Kazuhide Higuchi. Comparative Proteome Analysis of Indomethacin-Treated Intestinal Cells Reveals Down-Regulation of Collagen I in NSAID-Induced Intestinal Injury. DIGESTION. 2015. 91. 1. 90-90
Shoko Edogawa, Akiko Sakai, Takuya Inoue, Satoshi Harada, Toshihisa Takeuchi, Eiji Umegaki, Hideyuki Hayashi, Kazuhide Higuchi. Down-Regulation of Collagen I Biosynthesis in Intestinal Epithelial Cells Exposed to Indomethacin: A Comparative Proteome Analysis. DIGESTIVE DISEASES AND SCIENCES. 2014. 59. 9. 2016-2016
Shoko Edogawa, Akiko Sakai, Takuya Inoue, Satoshi Harada, Toshihisa Takeuchi, Eiji Umegaki, Hideyuki Hayashi, Kazuhide Higuchi. Down-regulation of collagen I biosynthesis in intestinal epithelial cells exposed to indomethacin: A comparative proteome analysis. JOURNAL OF PROTEOMICS. 2014. 103. 35-46

MISC (5)：

江戸川祥子, 梅垣英次, 原田智, 楢林賢, 藤原薫, 小嶋融一, 太田和寛, 竹内利寿, 井上拓也, 樋口和秀, et al. プロテオーム解析を用いた,インドメタシン起因性小腸粘膜傷害における発現蛋白の検討. 日本潰瘍学会プログラム・抄録集. 2013. 41st. 80
Kato Takayuki, Ueta Masami, Miyata Tomoko, Yoshida Hideji, Maki Yasushi, Furuike Shou, Sakai Akiko, Wada Akira, Namba Keiichi. 3D1434 P18 The Survival strategy in bacteria under the starvation stress(3D Protein: Structure & Function 3,The 49th Annual Meeting of the Biophysical Society of Japan). Seibutsu Butsuri. 2011. 51. S120
吉田秀司, 牧泰史, 古池晶, 境晶子, 上田雅美, 和田明. 内膜およびリボソームに結合する大腸菌蛋白質YqjDの特性. 日本分子生物学会年会プログラム・要旨集(Web). 2011. 34th
田中覚, 境晶子, 木村光誠, 吉田秀司, 尾方章人, 福島正和, 和田明, 谷川允彦. HP-031-1 RFHR2次元電気泳動法を用いた,大腸癌細胞株における5-FU体制に関連する塩基性蛋白の解析(大腸がん(基礎研究1),ハイブリッドポスター,第109回日本外科学会定期学術集会). 日本外科学会雑誌. 2009. 110. 2. 447-447
加藤貴之, 吉田秀司, 牧泰史, 古池晶, 上田雅美, 境晶子, 和田明, 難波啓一. GraFix法により安定化した100SリボソームのcryoEMによる構造解析. 日本RNA学会年会要旨集. 2009. 11th

Patents (2)：

Professional career (1)：

Work history (5)：

Association Membership(s) (3)：

日本電気泳動学会 , 日本分子生物学会 , 日本生化学会

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