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J-GLOBAL ID：200901065977254500   Update date: Nov. 19, 2024

Kume Shoen

クメ ショウエン | Kume Shoen
Affiliation and department：
Institute of Science Tokyo School of Life Science and Technology

About Institute of Science Tokyo School of Life Science and Technology


Job title： Professor
Research field  (1)： Developmental biology
Research keywords  (1)： 発生生物学
Research theme for competitive and other funds  (17)：
  • 2021 - 2024 Elucidation of the molecular mechanism regulating pancreatic islets using human pluripotent stem cell differentiation system
  • 2018 - 2021 The mechanism for the maintenance of pancreatic beta cells derived by in vitro differentiation of human pluripotent stem cells
  • 2016 - 2019 Research on innovative cell transplantation device using immunoisolation membrane
  • 2014 - 2017 Generation of human iPS-derived pancreatic beta cells and its application towards regenerative medicine
  • 2014 - 2016 The purification and expansion of human iPS cell-derived intestinal precursor cells for future application in regenerative medicine
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Papers (124)：
  • Dhimas Agung Kurniawan, Sylvia Leo, Mutsumi Inamatsu, Sohei Funaoka, Taichi Aihara, Mizuno Aiko, Inoue Rei, Takeshi Sakura, Hiroshi Arakawa, Yukio Kato, et al. Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism. PNAS Nexus. 2024
  • Kenta Ouchi, Kaori Isono, Yuki Ohya, Nobuaki Shiraki, Masayoshi Tasaki, Yukihiro Inomata, Mitsuharu Ueda, Takumi Era, Shoen Kume, Yukio Ando, et al. Characterization of heterozygous ATTR Tyr114Cys amyloidosis-specific induced pluripotent stem cells. Heliyon. 2024. 10. 2. e24590
  • Yumeng Wu, Tatsuya Yano, Takayuki Enomoto, Atena Endo, Seiji Okada, Kimi Araki, Nobuaki Shiraki, Shoen Kume. Reversal of Hyperglycemia by Subcutaneous Islet Engraftment Using an Atelocollagen Sponge as a Scaffold. Cell transplantation. 2024. 33. 9636897241277980-9636897241277980
  • Hiraku Tokuma, Daisuke Sakano, Katsuya Tanabe, Yukio Tanizawa, Nobuaki Shiraki, Shoen Kume. Selective proteasome degradation of C-terminally-truncated human WFS1 in pancreatic beta cells. FEBS open bio. 2023. 13. 8. 1405-1414
  • Sylvia Leo, Yusuke Kato, Yu Meng Wu, Mutsumi Yokota, Masato Koike, Shiro Yui, Kiichiro Tsuchiya, Nobuaki Shiraki, Shoen Kume. The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells. Stem cells (Dayton, Ohio). 2023
ｍore...
MISC (175)：
  • 白木伸明, 粂昭苑. Control of stem cell differentiation through regulation of methionine metabolism. 日本再生医療学会総会(Web). 2022. 21st
  • 白木伸明, ERINN Sim Zixuan, 榎本孝幸, 古田奈央, 樫尾宗志朗, 神戸大朋, 津山友徳, 荒川哲大, 小澤弘樹, 横山水穂, et al. Methionine metabolism regulates pluripotent stem cell through zinc mobilization. Biomedical Research on Trace Elements (Web). 2022. 33. 1
  • 石部隆之介, SYLVIA Leo, 渡邊輝彦, 白木伸明, 粂昭苑. 吸収腸上皮細胞への分化を促進する低分子化合物のスクリーニング. 日本再生医療学会総会(Web). 2021. 20th
  • 稲村恒亮, 三ツ田愛美, 木村啓志, 前川敏郎, 川田大輝, 河西巧, 荒川大, 加藤将夫, 白木伸明, 粂昭苑, et al. iPS細胞由来腸管細胞を搭載したMPSデバイスの開発とin vitro評価. 日本再生医療学会総会(Web). 2021. 20th
  • 渡邊輝彦, 石川晶也, 加藤祐介, 石部隆之介, 白木伸明, 粂昭苑. コラーゲンビトリゲル膜と新規培地で培養したヒトiPS細胞由来小腸細胞の有用性. 日本再生医療学会総会(Web). 2021. 20th
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Lectures and oral presentations  (143)：
  • マウスES細胞から膵臓の分化誘導
    (第35回日本発生生物学会大会)
  • ES細胞からの膵細胞分化
    (第23回炎症再生学会、2002年)
  • In vitro differentiation of ES cells into Pdx-1 expressing Endodermal cells
    (International Symposium on Dynamics o of Developmental systems、2005年)
  • 膵の発生分化と幹細胞系を用いた膵の再生医学
    (第52回日本臨床検査医学会総会第45回日本臨床化学会年会連合大会、2005年)
  • ES細胞から膵幹細胞へ分化誘導方法の開発-膵臓の再生医学-
    (第20回熊本県産学官技術交流会、2006年)
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Professional career (2)：
  • 修士 (東京大学)
  • 博士(理学) (大阪大学)
Work history (3)：
  • 2014 - 現在 Tokyo Institute of Technology School of Life Science and Technology
  • 2009 - 2014 Kumamoto University Institute of Molecular Embryology and Genetics
  • 2002 - 2009 Kumamoto University Institute of Molecular Embryology and Genetics, Institute of Molecular Embriology and Genetic Professor
Association Membership(s) (10)：
国際幹細胞学会 ,  The Japan Endocrine Society ,  THE JAPAN DIABETES SOCIETY ,  THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE ,  JAPAN SOCIETY FOR CELL BIOLOGY ,  THE JAPANESE SOCIETY OF INFLAMMATION AND REGENERATION ,  THE JAPANESE TISSUE CULTURE ASSOCIATION ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  The Molecular Biology Society of Japan ,  日本発生生物学会
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