Nagane Motoo

ナガネモトオ | Nagane Motoo

Affiliation and department：
Job title： Professor

Research field (1)： Neurosurgery

Research keywords (5)：脳腫瘍学 , 脳神経外科 , Neuro-Oncology , Brain Tumor , Neurosurgery

Research theme for competitive and other funds (26)：

2021 - 2024 脳悪性リンパ腫における髄液中DNAの特異的遺伝子変異検出による診断の前方視的検討
2020 - 2024 中枢神経系悪性リンパ腫の腫瘍内多様性と微小環境解析による病態発生の解明と治療開発
2020 - 2023 中枢神経系悪性リンパ腫臨床試験における網羅的遺伝子解析による予後及び予測因子解析
2018 - 2021 Development of individualized therapy by elucidation of molecular mechanisms for hypermutation phenotype induced by treatment with alkylating agents in glioma
2018 - 2021 Comparative genetic analysis of central nervous system lymphomas between sites in the central nervous system or extracranial organs

2016 - 2020 Functional analysis of specific genetic alterations in primary central nervous system lymphomas and development of novel molecular targeted therapies

2015 - 2018 Novel methylation markers of glioma and glioma stemcell and their application to individualized medicine

2014 - 2017 Genetic alterations and prognostic factors for primary central nervous system lymphoma treated with R-MPV-A combination immunochemotherapy

2013 - 2017 Novel strategy to enhance temozolomide sensitivity with interference of base excision DNA repair system for malignant glioma

2011 - 2013 Investigation of biological effects of IDH gene mutation in malignant glioma

2011 - 2013 Investigation of molecular genetic alterations and prognostic factors of primary central nervous system lymphoma

2010 - 2012 Development of novel combined therapies with anti-EGFR monoclonal antibody and anticancer drug for malignant gliomas

2009 - 2011 Investigation of mechanisms of drug resistance in malignant brain tumor stem cells

2007 - 2009 Novel therapeutic strategy by inhibition of multiple signal transduction pathways for malignant gliomas

2006 - 2008 Novel therapeutic strategy by combination of histone deacetylase inhibitors and death signal activators for malignant brain tumors

2006 - 2008 Targeting of neutral amino acid transporters as a novel therapeutic strategy for malignant glioma

2005 - 2006 Investigation of therapeutic activity of fully human anti-human TRAIL receptor monoclonal antibodies against malignant glioma

2003 - 2004 Investigation of biological significance of neutral amino acid transporter expression in human brain tumors and development of novel therapeutic strategies

2001 - 2002 Investigation of molecular mechanisms of cell death induced by combination treatment with TRAIL and chemotherapy in malignant gliomas

悪性脳腫瘍における薬剤耐性機構の研究

悪性脳腫瘍発生の分子生物学

悪性脳腫瘍の治療

Study on molecular mechanism for drug resistance in malignant brain tumors

Study on molecular mechanisms for drug resistance in malignant brain tumors

Molecular biology of malignant brain tumors

Treatment of malignant brain tumors

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Papers (94)：

Kaishi Satomi, Takahiro Shibayama, Takashi Hibiya, Akimasa Hayashi, Kiyotaka Nagahama, Kenichiro Kato, Yukino Nikai, Yuko Matsushita, Miho Gomyo, Yuki Yamagishi, et al. MYB::QKI fusion-positive diffuse glioma of the cerebellum: A case report. Neuropathology : official journal of the Japanese Society of Neuropathology. 2024
Kazuya Motomura, Keita Sasaki, Narushi Sugii, Shigeru Yamaguchi, Hirotaka Inoue, Akito Oshima, Kazuhiro Tanaka, Yoshihiro Otani, Mitsuaki Shirahata, Ichiyo Shibahara, et al. Cost of medical care for malignant brain tumors at hospitals in the Japan Clinical Oncology Group brain-tumor study group. Japanese journal of clinical oncology. 2024. 54. 10. 1123-1131
鬼塚裕美, 増井憲太, 新田雅之, 村垣善浩, 川俣貴一, 里見介史, 林玲匡, 永根基雄, 小森隆司, 柴原純二. びまん性正中膠腫におけるH3K27me3減少はGSH代謝依存的に細胞生存を促進する(H3 p.K27me3 loss promotes GSH-dependent cell survival in diffuse midline glioma). 日本病理学会会誌. 2024. 113. 1. 331-332
Hajime Yonezawa, Yoshitaka Narita, Motoo Nagane, Kazuhiko Mishima, Yasuhito Terui, Yoshiki Arakawa, Katsunori Asai, Noriko Fukuhara, Kazuhiko Sugiyama, Naoki Shinojima, et al. Three-year follow-up analysis of phase 1/2 study on tirabrutinib in patients with relapsed or refractory primary central nervous system lymphoma. Neuro-oncology advances. 2024. 6. 1. vdae037
Sukwoo Hong, Keisuke Maruyama, Akio Noguchi, Teruyuki Hirano, Motoo Nagane, Yoshiaki Shiokawa. Is using intracerebral hemorrhage scoring systems valid for mortality prediction in surgically treated patients?. Neurosurgical Review. 2021. 44. 5. 2747-2753

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MISC (103)：

松谷智郎, 張博実, 廣野誠一郎, 永根基雄, 吉野篤緒, 田中將太, 石川栄一, 深見真二郎, 山口文雄, 李淑洋, et al. Serum anti-zinc finger FYVE domain-containing protein 21 (ZFYVE21) autoantibody as a novel biomarker for oligodendroglioma IDH-mutant and 1p/19q co-deletion. 日本脳腫瘍学会学術集会プログラム・抄録集. 2021. 39th
田中將太, 成田善孝, 武笠晃丈, 永根基雄, 青木友和, 若林俊彦, 宇塚岳夫, 中村英夫, 中村英夫, 荒川芳輝, et al. Net clinical benefit analysis of BIOMARK. 日本脳腫瘍学会プログラム・抄録集. 2020. 38th
Motoo Nagane, Yoshitaka Narita, Kazuhiko Mishima, Yasuhito Terui, Yoshiki Arakawa, Hajime Yonezawa, Katsunori Asai, Noriko Fukuhara, Kazuhiko Sugiyama, Naoki Shinojima, et al. Phase 1/2 Study of Tirabrutinib (ONO/GS-4059), a Next-Generation Bruton's Tyrosine Kinase (BTK) Inhibitor, Monotherapy in Patients with Relapsed/ Refractory Primary Central Nervous System Lymphoma (PCNSL). BLOOD. 2019. 134
根城尭英, 松下博和, 野村昌志, 田中將太, 永江玄太, 成田善孝, 永根基雄, 西川亮, 植木敬介, 油谷浩幸, et al. 神経膠腫におけるネオアンチゲンと免疫微小環境の経時変化に関するマルチオミクス解析(Integrated Omics Analysis on Temporal Changes of Neoantigen and Tumor Microenvironment in Primary and Recurrent Gliomas). 日本癌学会総会記事. 2018. 77回. 1778-1778
久米賢, 永根基雄. 【周術期薬物療法の新しい戦略】各臓器がんに対する周術期治療エビデンス・展望脳腫瘍. 腫瘍内科. 2017. 20. 6. 630-637

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Books (1)：

脳腫瘍の分子生物学.脳腫瘍I,脳神経外科学大系6, 第1版,山浦晶編
中山書店,東京 2004

Education (2)：

- 1984 The University of Tokyo Faculty of Medicine School of Medicine
- 1984 The University of Tokyo Faculty of Medicine

Professional career (1)：

Ph. D. (The University of Tokyo)

Work history (12)：

2012/04 - 現在 Kyorin University Faculty of Medicine Department of Neurosurgery Professor
2007/04 - 2012/03 Kyorin University Faculty of Medicine Department of Neurosurgery Associate Professor
2005/04 - 2007/03 Kyorin University Faculty of Medicine
2000/02 - 2005/03 Kyorin University Faculty of Medicine Department of Neurosurgery Assitant Professor
1995 - 2000 ルードイッヒ癌研究所ポストドットラル・フェロー

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Committee career (3)：

2017/05 - 現在日本脳腫瘍病理学会理事
2016/09 - 現在日本脳腫瘍学会副理事長
1994 - 日本脳神経外科学会評議員

Awards (4)：

2009/10 - 日本癌治療学会優秀演題賞
1999 - Young Investigator Award(第13回国際脳腫瘍研究治療カンファランス)
1999 - Young Investigator(Travel)Award(AACR)アメリカ癌学会
1999 - 星野賞

Association Membership(s) (6)：

日本臨床腫瘍学会 , 日本癌治療学会 , 日本脳腫瘍病理学会 , 日本脳神経外科学会 , American Association for Cancer Research , 日本脳腫瘍学会

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