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J-GLOBAL ID：200901066156025231 Update date: Feb. 06, 2025

Tanaka Nobutada

タナカノブタダ | Tanaka Nobutada

Affiliation and department：
Job title：教授

Research field (5)： Applied biochemistry , Applied microbiology , Pharmaceuticals - chemistry and drug development , Pharmaceuticals - analytical and physicochemistry , Structural biochemistry

Research keywords (5)：ケミカルバイオロジー , 農芸化学 , 創薬化学 , 物理系薬学 , 構造生物化学

Research theme for competitive and other funds (31)：

2024 - 2027 選択的ジペプチジルペプチダーゼ阻害剤による糖尿病関連歯周炎に対する創薬研究
2023 - 2026 Development of allosteric chaperone compounds based on structural information of the target enzymes
2021 - 2024 ジペプチジルペプチダーゼを標的とした新規歯周病医薬開発
2019 - 2023 糖非発酵性細菌ペプチダーゼ類を標的とした新規阻害剤配合剤の開発
2016 - 2020 Development of novel antibiotics targeting peptidases of non-fermenting gram negative rods.

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Papers (83)：

Talea Knak, Sana Takada, Boris Illarionov, Violetta Krisilia, Lais Pessanha de Carvalho, Beate Lungerich, Yasumitsu Sakamoto, Stefan Höfmann, Adelbert Bacher, Rainer Kalscheuer, et al. Expanding the Chemical Space of Reverse Fosmidomycin Analogs. ACS medicinal chemistry letters. 2025. 16. 1. 136-143
Sana Takada, Mona A. Abdullaziz, Stefan Höfmann, Talea Knak, Shin-ichiro Ozawa, Yasumitsu Sakamoto, Thomas Kurz, Nobutada Tanaka. The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents. Molecules. 2024
Mona A. Abdullaziz, Sana Takada, Boris Illarionov, Lais Pessanha de Carvalho, Yasumitsu Sakamoto, Stefan Höfmann, Talea Knak, Anna-Lene Kiffe-Delf, Flaminia Mazzone, Klaus Pfeffer, et al. Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR). ACS Infectious Diseases. 2024. 10. 5. 1739-1752
Mitsuru Okuwaki, Shin-Ichiro Ozawa, Shuhei Ebine, Motoki Juichi, Tadanobu Umeki, Kazuki Niioka, Taiyo Kikuchi, Nobutada Tanaka. The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets. The Journal of Biochemistry. 2023. 174. 5. 461-476
Atsushi Kato, Izumi Nakagome, Maki Kise, Kousuke Yoshimura, Nobutada Tanaka, Robert J. Nash, George W. J. Fleet, Yota Kobayashi, Hayato Ikeda, Takuya Okada, et al. Design and Pharmacological Chaperone Effects of N-(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase. Journal of Medicinal Chemistry. 2023. 66. 13. 9023-9039

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MISC (169)：

SAKAMOTO Yasumitsu, ROPPONGI Saori, NAKAMURA Akihiro, TANAKA Nobutada. X-ray crystallographic analysis of Stenotrophomonas maltophilia DPP7. KEK Progress Report (Web). 2022. 2022-5
阪本泰光, 日高興士, 石原司, 中村彰宏, 鈴木義之, 關谷瑞樹, 六本木沙織, 小笠原渉, 田中信忠. Development of inhibitors with a novel mechanism of action targeting S46 DPPs in nonfermenting pathogens. 放射光. 2022. 35. 2
阪本泰光, 中村彰宏, 鈴木義之, 六本木沙織, 櫛引千里, 米澤夏里, 高橋聖人, 志田洋介, 合田浩明, 野中孝昌, et al. Structural basis for the antibacterial drug development against the multidrug-resistant strain Stenotrophomonas maltophilia DPP7. 日本薬学会年会要旨集(Web). 2022. 142nd
中村彰宏, 阪本泰光, 鈴木義之, 六本木沙織, 志田洋介, 田中信忠, 小笠原渉. 病原性細菌由来ジペプチジルペプチダーゼのS2サブサイト特異性の構造的基盤. 日本蛋白質科学会年会プログラム・要旨集. 2022. 22nd (Web)
中村彰宏, 阪本泰光, 鈴木義之, 六本木沙織, 志田洋介, 田中信忠, 田中信忠, 小笠原渉. Preference and molecular basis of substrate recognition at the P2 residues in the Dipeptidyl peptidase from pathogens. 日本農芸化学会大会講演要旨集(Web). 2021. 2021

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Lectures and oral presentations (30)：

PPI界面のアミノ酸残基傾向
(日本薬学会第144年会 2024)
ポンペ病標的酵素GAAに対する薬理学的シャペロンの開発を支援するためのイミノ糖疎水性置換基誘導体に対するイン・シリコ解析
(日本薬学会第144年会 2024)
GAA活性中心近傍に存在する疎水性ポケットの発見とポンペ病に対する選択的シャペロン化合物の創製
(日本薬学会第144年会 2024)
フラグメントベース手法に基づく新規DPP8阻害剤の同定
(日本薬学会第144年会 2024)
ヒト単量体カルボニル還元酵素とフラボノイド化合物との複合体のX線結晶構造解析
(日本薬学会第144年会 2024)

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Education (4)：

1994 - 1996 Nagaoka University of Technology Graduate School of Engineering
1992 - 1994 Nagaoka University of Technology Graduate School of Engineering
1990 - 1992 Nagaoka University of Technology Faculty of Engineering BioEngineering Course
1985 - 1990 National Institute of Technology, Hakodate College

Professional career (1)：

(BLANK) (Nagaoka University of Technology)

Work history (6)：

2020/04 - 現在 Kitasato University School of Pharmacy, Laboratory of Physical Chemistry for Drug Design Professor
2020 - 現在 Showa University
2008 - 2020 Showa University School of Pharmacy, Center for Molecular Analysis Associate Professor
2000 - 2008 Showa University School of Pharmacy, Physical Chemistry
1996 - 2000 Showa University School of Pharmacy, Physical Chemistry

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Committee career (3)：

2015/05 - 現在 Editorial Board Member, Scientific Reports
2015/04 - 現在 Photon Factory User Association (PF-UA) 庶務副幹事
2012/04 - 現在 Photon Factory User Association (PF-UA) 会計幹事

Awards (4)：

2017/05 - 昭和大学上條奨学賞「病原生物固有の代謝経路を標的とした抗菌薬開発に係る基盤研究」
2007/03 - 日本薬学会奨励賞「創薬の標的と成り得る蛋白質群に関する構造生物学的研究」
2004/11 - 昭和大学上條奨学賞「創薬を指向した構造生物学的研究」
1989/08 - 全国高等専門学校サッカー選手権大会優秀選手

Association Membership(s) (3)：

日本結晶学会 , 日本薬学会 , 日本生化学会

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