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Rchr

J-GLOBAL ID：200901066179053119 Update date: Jan. 05, 2025

Fujii Hodaka

フジイホダカ | Fujii Hodaka

Affiliation and department：
Job title：教授
Homepage URL (1)： http://www.med.hirosaki-u.ac.jp/~bgb/

Research field (2)： Medical biochemistry , Molecular biology

Research keywords (5)： chromatin , biochemistry , molecular biology , Epigenetics , Molecular Immunology

Research theme for competitive and other funds (35)：

2023 - 2026 遺伝子座特異的ChIP法を用いたMYCN増幅神経芽腫MYCN遺伝子の転写制御機構の解明
2023 - 2026 ブロッキング核酸増幅阻害法による血中癌関連遺伝子変異検出による癌病態動態の可視化
2024 - 2024 非侵襲的に採取可能な検体中の核酸検出による難治疾患の早期発見技術の開発
2023 - 遺伝子座特異的ChIP法による難治疾患の創薬標的の探索
2015 - 2018 Identification and characterization of interactions between genomic regions using the locus-specific chromatin immunoprecipitation technology

2015 - 2017 遺伝子座特異的クロマチン免疫沈降法による細胞分化制御因子の転写機構の解明

2014 - 2017 Chromatin dynamics induced by inflammatory stimulation

2014 - 2016 Elucidation of locus specific chromatin complex formation and energy expenditure gene expressions using enChIP

2014 - 2016 Analysis of higher-order structures of mitochondria DNA using the enChIP technology

2014 - 2015 エピジェネティックな遺伝子調節タンパク質に基づく発達障害疾患の創薬基盤の構築

2013 - 2015 Analysis of molecular mechanisms of epigenetic regulation by combining technology and life science: locus-specific biochemical epigenetics analysis by insertional chromatin immunoprecipitation (iChIP)

2013 - 2015 挿入的クロマチン免疫沈降法(iChIP)による細胞分化制御因子の転写機構の解明

2014 - 2015 Locus-specific biochemical analysis of genome functions using the enChIP technology

2014 - 2015 Locus-specific biochemical analysis of genome functions in T cell development

2013 - 2014 Simplification and adaptation of the iChIP method to beads formats

2013 - 2014 Development of simplified eChIP system using CRISPR with inactive Cas9

2011 - 2014 Roles of the GARP protein in functions of regulatory T cells

2012 - 2013 Analysis of molecular mechanisms of suppression of expression of tumor suppressor genes by epigenetic mechanisms

2012 - 2013 Analysis of mechanisms of epigenetic suppression of expression of tumor suppressor genes: identification of drug targets of tumorigenesis by epigenetic mechanisms

2012 - 2013 Analysis of roles of the GARP protein in thymocyte development

2012 - 2013 Analysis of mechanisms to prevent rheumatism

2011 - 2013 挿入的クロマチン免疫沈降法によるエピジェネティック制御機構の解明

2011 - 2012 Analysis of mechanisms of immune regulation by regulatory T cells

2011 - 2012 Molecular mechanisms of immune regulation by regulatory T cells

2011 - 2012 Development of a new therapy against cancer and retroviral diseases by sequence-specific killing

2009 - 2010 Development of a novel anti-tumor therapy using sequence-specific enzyme complementation

2009 - 2010 Elimination of cancer cells harboring mutations in oncogenes and tumor-suppressor genes by sequence-specific enzyme complementation

2009 - 2010 Analysis of mechanisms to prevent autoimmune diseases

2004 - 2007 Cytokine signal transduction in immune system

1999 - 2000 Mechanism of proliferative signal transduction from cytokine receptors

1999 - 2000 IL-2受容体γc鎖トランスジェニックマウスの作製とその解析

1998 - 1999 Mechanism of signal transduction from IL-2Rγc for lymphocyte proliferation and differentiation

1998 - 1999 Functional dissection of the IL-2Rβc chain

1995 - 1998 Grant-in-Aid for JSPS Research Fellow

1998 - 1998 細胞膜情報交換系の構造、機能解析と個体レベルでの役割

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Papers (91)：

Mina Ishidoya, Toshitsugu Fujita, Hodaka Fujii. Blocking RPA-based methods for the determination of CpG methylation status and detection of gene mutations. Epigenomics. 2024. 1-3
Chiori Tabe, Toshitsugu Fujita, Kageaki Taima, Hisashi Tanaka, Tomonori Makiguchi, Masamichi Itoga, Yoshiko Ishioka, Sadatomo Tasaka, Hodaka Fujii. Highly sensitive and accurate detection of ALK-TKI resistance mutations by oligoribonucleotide interference-PCR (ORNi-PCR)-based methods. Lung Cancer. 2024. 197. 107969-107969
Hiroaki Fujita, Toshitsugu Fujita, Keinosuke Ishido, Kenichi Hakamada, Hodaka Fujii. Oligoribonucleotide interference-PCR-based methods for the sensitive and accurate detection of KRAS mutations. Biology Methods and Protocols. 2024. 9. 1
Mina Ishidoya, Toshitsugu Fujita, Sadatomo Tasaka, Hodaka Fujii. Real-time MBDi-RPA using methyl-CpG binding protein 2: A real-time detection method for simple and rapid estimation of CpG methylation status. Analytica chimica acta. 2024. 1302. 342486-342486
Toshitsugu Fujita, Hodaka Fujii. iChIP-SILAC analysis identifies epigenetic regulators of CpG methylation of the p16INK4A gene. FEBS letters. 2024

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MISC (11)：

清水武史, 馬場啓介, 藤田敏次, 藤井穂高. Detection of single-nucleotide mutations of cancer driver genes and polymorphisms in tissue specimens by ORNi-PCR. 日本癌学会学術総会抄録集(Web). 2020. 79th
横山雄起, 武田和, 藤田敏次, 奥崎大介, 杉山真美, 浅井香穂, 高橋秀和, 藤井穂高, 森正樹, 山本浩文, et al. The regulation mechanism of KLF5 gene expression via three-dimensional genome structure in colorectal cancer. 日本癌学会学術総会抄録集(Web). 2020. 79th
武田和, 横山雄起, 藤田敏次, 北川公望, 廣瀬遥香, 高橋秀和, 植村守, 松田宙, 水島恒和, 森正樹, et al. 大腸癌細胞株におけるKLF5エンハンサー領域の同定(Identification of the KLF5 enhancer region in colon cancer cell lines). 日本癌学会総会記事. 2019. 78回. P-3056
馬場啓介, 馬場啓介, 藤田敏次, 田坂定智, 藤井穂高. ORNi-PCR法による肺癌EGFR遺伝子L858R変異とT790M変異の同時検出. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
Identification of molecules associated with specific genomic regions and analysis of higher-order chromosome conformation using the locus-specific chromatin immunoprecipitation technology. 2017. 68. 3. 189-193

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Patents (15)：

Method for isolating specific genomic regions with use of molecule capable of specifically binding to endogenous DNA sequence
Method for detecting difference in reference sequence in target nucleic acid region
Method for detecting difference in reference sequence in target nucleic acid region
核酸増幅の特異的抑制方法
Method for detecting difference in reference sequence in target nucleic acid region

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Education (2)：

- 1998 University of Tokyo Graduate School of Medicine Pathology
- 1994 University of Tokyo School of Medicine

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (5)：

2017/04 - 現在 Hirosaki University Graduate School of Medicine Department of Biochemistry and Genome Biology Professor
2009/04 - 2017/03 Osaka University Research Institute for Microbial Diseases Combined Program on Microbiology and Immunology Associate Professor
2001/12 - 2009/03 New York University School of Medicine Department of Pathology Assistant Professor
2000/04 - 2001/12 Basel Institute for Immunology member
1998/04 - 2001/12 University of Tokyo Graduate School of Medicine and Faculty of Medicine Department of Immunology Assistant Professor (Joshu)

Awards (6)：

2016 - Addgene Blue Flame Award
2015 - 学術振興会特別研究員等審査会専門委員表彰
2015 - Osaka University Osaka University Presidential Award for Encouragement
2014 - Osaka University Osaka University Presidential Award for Encouragement
2007 - The American Association of Immunologists Junior Faculty Travel Award

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Association Membership(s) (8)：

American Association for Cancer Research , 日本癌学会 , The Japanese Society for Epigenetics , The American Association of Immunologists , Molecular Biology Society of Japan , Japanese Society of Immunology , American Society for Biochemistry and Molecular Biology , The Japanese Biochemical Society

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