Research theme for competitive and other funds (31)：
2015 - 2018 Identification and characterization of interactions between genomic regions using the locus-specific chromatin immunoprecipitation technology
2015 - 2017 遺伝子座特異的クロマチン免疫沈降法による細胞分化制御因子の転写機構の解明
2014 - 2017 Chromatin dynamics induced by inflammatory stimulation
2014 - 2016 Elucidation of locus specific chromatin complex formation and energy expenditure gene expressions using enChIP
2014 - 2016 Analysis of higher-order structures of mitochondria DNA using the enChIP technology
2013 - 2015 Analysis of molecular mechanisms of epigenetic regulation by combining technology and life science: locus-specific biochemical epigenetics analysis by insertional chromatin immunoprecipitation (iChIP)
2014 - 2015 Locus-specific biochemical analysis of genome functions using the enChIP technology
2014 - 2015 Locus-specific biochemical analysis of genome functions in T cell development
2013 - 2014 Simplification and adaptation of the iChIP method to beads formats
2013 - 2014 Development of simplified eChIP system using CRISPR with inactive Cas9
2011 - 2014 Roles of the GARP protein in functions of regulatory T cells
2012 - 2013 Analysis of molecular mechanisms of suppression of expression of tumor suppressor genes by epigenetic mechanisms
2012 - 2013 Analysis of mechanisms of epigenetic suppression of expression of tumor suppressor genes: identification of drug targets of tumorigenesis by epigenetic mechanisms
2012 - 2013 Analysis of roles of the GARP protein in thymocyte development
2012 - 2013 Analysis of mechanisms to prevent rheumatism
2011 - 2013 挿入的クロマチン免疫沈降法によるエピジェネティック制御機構の解明
2011 - 2012 Analysis of mechanisms of immune regulation by regulatory T cells
2011 - 2012 Molecular mechanisms of immune regulation by regulatory T cells
2011 - 2012 Development of a new therapy against cancer and retroviral diseases by sequence-specific killing
2009 - 2010 Development of a novel anti-tumor therapy using sequence-specific enzyme complementation
2009 - 2010 Elimination of cancer cells harboring mutations in oncogenes and tumor-suppressor genes by sequence-specific enzyme complementation
2009 - 2010 Analysis of mechanisms to prevent autoimmune diseases
2004 - 2007 Cytokine signal transduction in immune system
1999 - 2000 Mechanism of proliferative signal transduction from cytokine receptors
1999 - 2000 IL-2受容体γc鎖トランスジェニックマウスの作製とその解析
1998 - 1999 Mechanism of signal transduction from IL-2Rγc for lymphocyte proliferation and differentiation
1998 - 1999 Functional dissection of the IL-2Rβc chain
1995 - 1998 Grant-in-Aid for JSPS Research Fellow
1998 - 1998 細胞膜情報交換系の構造、機能解析と個体レベルでの役割
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Papers (87)：
Mina Ishidoya, Toshitsugu Fujita, Sadatomo Tasaka, Hodaka Fujii. Real-time MBDi-RPA using methyl-CpG binding protein 2: A real-time detection method for simple and rapid estimation of CpG methylation status. Analytica chimica acta. 2024. 1302. 342486-342486
Toshitsugu Fujita, Hodaka Fujii. iChIP-SILAC analysis identifies epigenetic regulators of CpG methylation of the p16INK4A gene. FEBS letters. 2024
Toshitsugu Fujita, Shoko Nagata, Hodaka Fujii. Oligoribonucleotide-Mediated Blockade of DNA Extension by Taq DNA Polymerases Increases Specificity and Sensitivity for Detecting Single-Nucleotide Differences. Analytical chemistry. 2023. 95. 6. 3442-3451
Sachiko Imanishi, Shoko Nagata, Toshitsugu Fujita, Hodaka Fujii. Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma. International journal of experimental pathology. 2022. 103. 6. 245-251
清水武史, 馬場啓介, 藤田敏次, 藤井穂高. Detection of single-nucleotide mutations of cancer driver genes and polymorphisms in tissue specimens by ORNi-PCR. 日本癌学会学術総会抄録集(Web). 2020. 79th
Identification of molecules associated with specific genomic regions and analysis of higher-order chromosome conformation using the locus-specific chromatin immunoprecipitation technology. 2017. 68. 3. 189-193
- 1998 University of Tokyo Graduate School of Medicine Pathology
- 1994 University of Tokyo School of Medicine
Professional career (1)：
Ph.D. (The University of Tokyo)
Work history (5)：
2017/04 - 現在 Hirosaki University Graduate School of Medicine Department of Biochemistry and Genome Biology Professor
2009/04 - 2017/03 Osaka University Research Institute for Microbial Diseases Combined Program on Microbiology and Immunology Associate Professor
2001/12 - 2009/03 New York University School of Medicine Department of Pathology Assistant Professor
2000/04 - 2001/12 Basel Institute for Immunology member
1998/04 - 2001/12 University of Tokyo Graduate School of Medicine and Faculty of Medicine Department of Immunology Assistant Professor (Joshu)
Awards (6)：
2016 - Addgene Blue Flame Award
2015 - 学術振興会 特別研究員等審査会専門委員表彰
2015 - Osaka University Osaka University Presidential Award for Encouragement
2014 - Osaka University Osaka University Presidential Award for Encouragement
2007 - The American Association of Immunologists Junior Faculty Travel Award
1995 - 東大医師会医学賞
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Association Membership(s) (8)：
American Association for Cancer Research
, 日本癌学会
, The Japanese Society for Epigenetics
, The American Association of Immunologists
, Molecular Biology Society of Japan
, Japanese Society of Immunology
, American Society for Biochemistry and Molecular Biology
, The Japanese Biochemical Society
