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J-GLOBAL ID：200901066465048637 Update date: Feb. 05, 2025

Isogai Yasuhiro

Research field (1)： Structural biochemistry

Research theme for competitive and other funds (13)：

2011 - 2015 Design and syntheses of antibiotic acylase mutants based on 3D structure
2006 - 2009 Studies on protein structure-function relationship by de novo design
2004 - 2005 人工タンパク質のデザインとフォールディング
2003 - 2005 De novo design of artificial proteins with structural specificity as if they were native protains
2001 - 2003 Design and laboratory evolution of artificial proteins

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Papers (54)：

Yoshihiro Osaka, Ryuichi Okamoto, Tomonari Sumi, Kenichiro Koga, Hiroshi Imamura, Tsuyoshi Shirai, Yasuhiro Isogai. Mechanism of polymer molecular weight-dependent suppression and promotion of liquid-liquid phase separation of a protein solution by the addition of polymer. The Journal of Chemical Physics. 2025
Daijiro Ueda, Natsu Matsuda, Yuka Takaba, Nami Hirai, Mao Inoue, Taichi Kameya, Tohru Abe, Nao Tagaya, Yasuhiro Isogai, Yoshito Kakihara, et al. Analysis of vitamin D receptor binding affinities of enzymatically synthesized triterpenes including ambrein and unnatural onoceroids. Scientific Reports. 2024. 14. 1
Miyu Nishikawa, Naruhiro Murose, Hiroki Mano, Kaori Yasuda, Yasuhiro Isogai, Atsushi Kittaka, Masashi Takano, Shinichi Ikushiro, Toshiyuki Sakaki. Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats. Scientific reports. 2022. 12. 1. 12517-12517
Yasuhiro Isogai, Hiroshi Imamura, Tomonari Sumi, Tsuyoshi Shirai. Improvement of Protein Solubility in Macromolecular Crowding during Myoglobin Evolution. Biochemistry. 2022
Madhu Biyani, Kaori Yasuda, Yasuhiro Isogai, Yuki Okamoto, Wei Weilin, Noriyuki Kodera, Holger Flechsig, Toshiyuki Sakaki, Miki Nakajima, Manish Biyani. Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells. ACS applied materials & interfaces. 2022. 14. 16. 18064-18078

MISC (24)：

Patents (1)：

Books (2)：

Physiological functions and molecular structures of new types of hemoproteins
Progress in Biotechnology 22: 189-204, 2002 2002
人工タンパク質の合理的設計
シリーズ・ニューバイオフィジックスII「生体ナノマシンの分子設計」、共立出版 2001

Works (3)：

Professional career (1)：

Awards (1)：

Association Membership(s) (4)：

日本蛋白質科学会 , 日本分子生物学会 , 日本生化学会 , 日本生物物理学会

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