Rchr
J-GLOBAL ID：200901066572016152   Update date: Mar. 16, 2024

Nakanishi Takeshi

ナカニシ タケシ | Nakanishi Takeshi
Affiliation and department：
Osaka Metropolitan University Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology

About Osaka Metropolitan University Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology


Job title： Associate Professor
Research field  (2)： Functional biochemistry ,  Functional biochemistry
Research keywords  (1)： タンパク質 抗体 遺伝子工学 相互作用解析 結晶構造解析
Research theme for competitive and other funds  (9)：
  • 2022 - 2025 Fc領域ヘテロ会合化を必要としない非対称二重特異性抗体の作製技術開発
  • 2019 - 2023 二重特異性抗体を用いたBNCTホウ素デリバリーシステムの開発
  • 2018 - 2022 Studies on microbiologically influenced corrosion mechanisms by spatial - temporal imaging of an internal environment of biofilm
  • 2017 - 2020 革新的なバイオ医薬創製に向けた分子連結技術の高度化
  • 2014 - 2017 Multiple analysis of FMN-binding reaction and consideration on molecular evolution based on structural information
Show all
Papers (55)：
  • Kouki Kimura, Atsushi Kuwahara, Saori Suzuki, Takeshi Nakanishi, Izumi Kumagai, Ryutaro Asano. Cancer therapeutic trispecific antibodies recruiting both T and natural killer cells to cancer cells. Oncology Reports. 2023. 50. 6. 212
  • Risa Yamada, Ishin Nakahara, Izumi Kumagai, Ryutaro Asano, Takeshi Nakanishi, Koki Makabe. Construction of IgG-Fab2 bispecific antibody via intein-mediated protein trans-splicing reaction. Scientific Reports. 2023. 13. 15961
  • Honoka Yamamoto, Takeshi Nakanishi, Kan-Ichiro Ihara, Taro Tachibana, Chikako Yokoyama. Generation of rat monoclonal antibodies against human epidermal growth factor receptor 2. Monoclon. Antib. Immunodiagn. Immunother. 2023. 42. 2. 59-64
  • Asano Ryutaro, Hosokawa Katsuhiro, Taki Shintaro, Konno Shota, Shimomura Ippei, Ogata Hiromi, Okada Mai, Arai Kyoko, Onitsuka Masayoshi, Omasa Takeshi, et al. Build-up functionalization of anti-EGFR x anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats. SCIENTIFIC REPORTS. 2020. 10. 1
  • Saki Hemmi, Ryutaro Asano, Kouki Kimura, Mitsuo Umetsu, Takeshi Nakanishi, Izumi Kumagai, Koki Makabe. Construction of a circularly connected VHH bispecific antibody (cyclobody) for the desirable positioning of antigen-binding sites. Biochem Biophys Res Commun. 2020. 523. 1. 72-77
ｍore...
MISC (2)：
  • 抗体医薬の最前線 抗体ドメインの積み木細工による高機能化と医用への展開. シーエムシー出版
  • 抗体ライブラリー技術の現状と今後の展望. 細胞工学
Books (2)：
  • 次世代医薬開発に向けた抗体工学の最前線 ファージ提示系による親和性の向上
    シーエムシー出版 2012
  • 抗体医薬の最前線 抗体ドメインの積み木細工による高機能化と医用への展開
    シーエムシー出版 2007
Education (4)：
  • - 2003 Osaka City University
  • - 2003 Osaka City University Graduate School, Division of Engineering
  • - 1998 Osaka City University
  • - 1998 Osaka City University Faculty of Engineering
Professional career (1)：
  • 博士(工学) (大阪市立大学)
Work history (3)：
  • 2022/04 - 現在 Osaka Metropolitan University School of Engineering Department of Chemistry and Bioengineering Associate Professor
  • 2018/10/01 - 現在 Osaka City University Graduate School of Engineering Applied Chemistry and Bioengineering Course Associate Professor
  • 2010/04/01 - 2018/09/30 Osaka City University Graduate School of Engineering Applied Chemistry and Bioengineering Course Lecturer
Association Membership(s) (2)：
日本蛋白質科学会 ,  Protein Science Society of Japan
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