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J-GLOBAL ID：200901066932650516 Update date: Mar. 26, 2025

Okajima Toshihide

オカジマトシヒデ | Okajima Toshihide

Affiliation and department：
Job title： Associate Professor

Research field (3)： Structural biochemistry , Applied biochemistry , Functional biochemistry

Research keywords (5)：創薬 , 酵素反応機構 , 構造生物学 , 酵素化学 , Enzyme chemistry

Research theme for competitive and other funds (22)：

2022 - 2025 Elucidation of the biogenesis mechanism of amine dehydrogenase by development of a low-cytotoxicity genome editing technique for bacteria
2023 - 2025 分子設計AIを活用した有機合成による機能性物質探索技術の効率化
2022 - 2025 Mechanistic analysis and its optimization of bioactive cyclic peptides constructed by a radical cross-linking enzyme
2020 - 2023 Development for quantum-theoretical approach by observing hydrogen atom positions in drug target proteins
2019 - 2022 Elucidation of quinone cofactor biogenesis in copper amine oxidase on the basis of proton structures and flexibility analysis

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Papers (108)：

Tadashi Nakai, Naoya Miyagi, Kota Hisamura, Shoya Matsuba, Kanji Nishimoto, Emi Nakai, Katsuyuki Tanizawa, Toshihide Okajima. Metabolic role of a genetically conserved aldehyde dehydrogenase in bacterial assimilation of various primary amines. Archives of Biochemistry and Biophysics. 2025. 768. 110387-110387
T. Murakawa, K. Kurihara, K. Kusaka, M. Adachi, T. Okajima. Neutron Crystallography of a Semiquinone Radical Intermediate of Copper Amine Oxidase. 2025. 24. 2. 7-9
Toshihide OKAJIMA, Teruhiko ISHIKAWA, Masayuki IGARASHI, Yoko EGUCHI, Ryutaro UTSUMI. New Generation of Antibacterial Drugs to Inhibit Bacterial Signal Transduction: Can Inhibitors Against Two-Component Systems Be a Breakthrough in Development of Drugs to Defeat Drug Resistant Bacteria?. 2024. 62. 480-489
Ryo Ito, Masaki Kamiya, Koichi Takayama, Sumito Mori, Rei Matsumoto, Mayuka Takebayashi, Hisanori Ojima, Shota Fujimura, Haruki Yamamoto, Masayuki Ohno, et al. Unravelling nicotinic receptor and ligand features underlying neonicotinoid knockdown actions on the malaria vector mosquito Anopheles gambiae. Open Biology. 2024. 14. 7
Teruhiko Ishikawa, Yoko Eguchi, Masayuki Igarashi, Toshihide Okajima, Kohei Mita, Yuri Yamasaki, Kaho Sumikura, Taisei Okumura, Yuna Tabuchi, Chigusa Hayashi, et al. Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases. The Journal of Antibiotics. 2024. 77. 8. 522-532

MISC (84)：

斎藤遥, 大原ひかる, 小林勇気, 田中寛, 五十嵐雅之, 内海龍太郎, 岡島俊英, 華岡光正, 華岡光正. Cyanidioschyzon merolaeの光応答転写制御におけるヘムの関与. 日本農芸化学会関東支部講演要旨集(CD-ROM). 2022. 2022
村川武志, 岡島俊英. 宙に浮く水素イオン?!-大型タンパク質の中性子結晶構造解析で見えた特異な世界-(4月28日、プレス発表). J-PARC News 第181号. 2020. 181. 2-2
宙に浮く水素イオン?! -大型タンパク質の中性子結晶構造解析で見えた特異な世界-. 量子科学技術研究開発機構. 2020
銅アミン酸化酵素の中性子結晶構造解析に成功 -宙に浮いているようにみえる水素イオンなど初めて解明. 茨城大学. 2020
宙に浮く水素イオン?! -大型タンパク質の中性子結晶構造解析で見えた特異な世界-. 大阪大学. 2020

Books (5)：

遺伝学の百科事典-継承と多様性の源
日本遺伝学会編、丸善出版社 2022
Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology
CRC Press, FL, USA 2009
酵素ハンドブック第3版
朝倉書店 2008
蛋白質科学
化学同人、京都 2006
構造生物学 : ヌクレオシド-リン酸キナーゼ
朝倉書店 1997

Education (2)：

- 1992 Osaka University
- 1987 Tokyo University of Science Faculty of Science and Technology Applied Biological Science

Professional career (1)：

Work history (5)：

2007/04 - 現在大阪大学産業科学研究所准教授
2002/11 - 2007/03 大阪大学産業科学研究所助教授
2000/04 - 2002/11 Osaka University The Institute of Scientific and Industrial Research
1995/04 - 2000/03 Kindai University Faculty of Agriculture
1992/04 - 1995/03 Kindai University Faculty of Agriculture

Awards (2)：

Association Membership(s) (4)：

日本蛋白科学会 , Protein Society , 日本農芸化学会 , 日本生化学会

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