Rchr
J-GLOBAL ID：200901068471356290   Update date: Dec. 18, 2024

Irimura Tatsuro

イリムラ タツロウ | Irimura Tatsuro
Affiliation and department：
順天堂大学 大学院医学研究科

About 順天堂大学 大学院医学研究科


Job title： 特任教授
Homepage URL  (1)： http://www.f.u-tokyo.ac.jp/~cancer/labpage/index.html
Research field  (4)： Pathobiochemistry ,  Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Structural biochemistry
Research keywords  (6)： 糖鎖生物学 ,  腫瘍生物学 ,  分子免疫学 ,  Glycobiology ,  Cancer Biology ,  Molecular Immunology
Research theme for competitive and other funds  (48)：
  • 2014 - 2018 Development of cancer stem cells driven by microenvironment
  • 2013 - 2017 MUC21 glycoforms as the target of cancer diagnosis and therapy
  • 2012 - 2015 Regulation of IgA responses against influenza virus
  • 2009 - 2013 Immune-suppressive function of cancer-associated mucin epiglycanin/Muc21
  • 2010 - 2011 A peptide sequence motif which regulates glycoforms
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Papers (267)：
  • Jia Shi, Yoshiki Onuki, Fumiya Kawanami, Naoko Miyagawa, Fumika Iwasaki, Haruna Tsuda, Katsuhiko Takahashi, Teruaki Oku, Masato Suzuki, Kyohei Higashi, et al. The Uptake of Heparanase into Mast Cells Is Regulated by Its Enzymatic Activity to Degrade Heparan Sulfate. International journal of molecular sciences. 2024. 25. 11
  • Yoshiya Horimoto, May Thinzar Hlaing, Harumi Saeki, Kaori Denda-Nagai, Katrin Ishii-Schrade, Haruhiko Fujihira, Masaaki Abe, Miki Noji, Shigeyuki Shichino, Mitsue Saito, et al. Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases. Clinical & experimental metastasis. 2024
  • Dong-Hee Lee, Hyejin Ahn, Hye-In Sim, Eunji Choi, Seunghyun Choi, Yunju Jo, Bohwan Yun, Hyun Kyu Song, Soo Jin Oh, Kaori Denda-Nagai, et al. A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. Journal of experimental & clinical cancer research : CR. 2023. 42. 1. 272-272
  • Yukari Manome-Zenke, Kaori Denda-Nagai, Ryuichi Murakami, Miki Noji, Naoto Tsuneda, Katrin Beate Ishii-Schrade, Naoki Kanomata, Satoru Arai, Tatsuro Irimura, Shigaku Ikeda. Possible Involvement of Antigen-Presenting Cells Expressing the Macrophage Galactose-Type C-Type Lectin in Inflammatory Skin Diseases. The Journal of investigative dermatology. 2023. 143. 9. 1834-1838
  • Ryoko Semba, Yoshiya Horimoto, Madoka Sakata-Matsuzawa, Yumiko Ishizuka, Kaori Denda-Nagai, Haruhiko Fujihira, Miki Noji, Hiroko Onagi, Miyu Ichida, Hiroyoshi Miura, et al. Possible correlation of apical localization of MUC1 glycoprotein with luminal A-like status of breast cancer. Scientific reports. 2023. 13. 1. 5281-5281
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MISC (419)：
  • SHI Jia, 高橋勝彦, 奥輝明, 中島元夫, 入村達郎, 東伸昭. Syndecans are involved in heparanase-mediated activation of NF-κB in colon cancer cells. 日本薬学会年会要旨集(Web). 2024. 144th
  • 藤澤柚香, SHI Jia, 高橋勝彦, 奥輝明, 中島元夫, 入村達郎, 東伸昭. Heparanase is involved in the regulation of expression of Syndecans in colon cancer cells. 日本薬学会年会要旨集(Web). 2024. 144th
  • 東之薗優輝, 服部萌, 稲月悠, 田中玲也, 高橋勝彦, 中島元夫, 入村達郎, 小宮根真弓, 東伸昭. Expression of heparinase in the skin of atopic dermatitis model mice. 日本薬学会年会要旨集(Web). 2024. 144th
  • 山口アリサ, 馬場遼也, 荒川颯二郎, 中村桃子, 高橋勝彦, 築地信, 中島元夫, 入村達郎, 東伸昭. Analysis of molecules to which heparanase fusion proteins bind. 日本薬学会年会要旨集(Web). 2024. 144th
  • SHI Jia, 高橋勝彦, 中島元夫, 入村達郎, 東伸昭. Heparanase-mediated activation of NF-κB signaling pathway: Involvement of syndecans. 日本薬学会年会要旨集(Web). 2023. 143rd
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Patents (12)：
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Works (4)：
  • 特許:ヘパラナ-ゼ阻害物質によるがんの抑制
    1991 -
  • Patent (US, European, Japanese, Canadian) Prevention of cancer growth by heparanase inhibitors
    1991 -
  • 特許:エンドグリコシダ-ゼ検出法
    1987 -
  • Patent (US, European, Japanese, Canadian) Endoglycosidare assay
    1987 -
Education (2)：
  • 1971 - 1974 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 1967 - 1971 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (3)：
  • (BLANK)
  • (BLANK)
  • Ph.D
Work history (10)：
  • 2022/04 - 現在 Juntendo University Medical School Department of Breast Oncology Visiting Professor
  • 2016/02 - 2022/03 Juntendo University Graduate School of Medicine・Faculty of Medicine Project Professor
  • 2015/04 - 2016/01 Juntendo University Graduate School of Medicine Visiting Professor
  • 2014/04 - 2015/03 St. Luke's International University Institute of Medical Innovation Director
  • 2013/04 - 2014/03 St. Luke's International Hospital Institute of Medical Innovation Director
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Committee career (8)：
  • 2016/09 - 2020/09 International Pharamceutical Federation Chair of Board of Pharmaceutical Sciences
  • 2012/06 - 2016/03 Pharmaceutical and Medical Devise Agency Chair of Science Board
  • 2012/04 - 2016/03 Science Council of Japan Adjunct member
  • 1998 - 2004 Metastasis Research Society Board Member
  • 1997 - 2000 Ministry of Health Member of Health Science Committee
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Awards (3)：
  • 2014/04 - 5th Pharmaceutical Science World Congress Recognition Award
  • 2013/09 - International Pharmaceutical Federation FIP Fellow
  • 2010/03 - Pharmaceutical Socierty of Japan Pharmaceutical Society Award
Association Membership(s) (7)：
International Pharmaeutical Federation ,  国際癌転移研究会 ,  アメリカ癌学会 ,  日本免疫学会 ,  日本癌学会 ,  日本薬学会 ,  日本生化学会
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