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J-GLOBAL ID：200901068553652245 Update date: Apr. 22, 2025

Nomura Masatoshi

ノムラマサトシ | Nomura Masatoshi

Affiliation and department：
Job title： professor
Other affiliations (1)：

Kurume University Hospital Hospital Director

Homepage URL (1)： http://www.med.kyushu-u.ac.jp/intmed3/

Research field (1)： Metabolism and endocrinology

Research keywords (11)： taste receptors , glutamate , mitochondria dynamics , Drp1 , TGF-beta , Parcreatic beta cell , Diabetes , TGF-beta , Activiu , Parcreatic betaballs , Regenertion

Research theme for competitive and other funds (37)：

2022 - 2025 GnRHシグナル制御による動脈硬化抑制作用の解明
2021 - 2023 大動脈解離における組織破壊の増幅機構を解明する:ATP分泌から見た病態解明
2020 - 2023 細胞内コルチゾール過剰作用による脂肪・骨格筋・骨の老化進展機構の解明
2020 - 2023 ATP signaling controlled by mitochondrial dynamics
2018 - 2021 A possible relevance of ghrelin to deteriorated self-control property in patients with obesity or type 2 diabetes

2018 - 2021 Structure, function and physiological significance of vesicular polyamine transporter

2017 - 2020 Mitochondrial dynamics regulating energy metabolism and chronic inflammation.

2017 - 2020 Analysis of hypoxia-induced RBPJ/MAML3-SMO activation pathway and development of therapeutic strategy against pancreatic cancer

2014 - 2017 Elucidation of organelle network mechanism controlled by mitochondrial dynamics and its application.

2014 - 2017 Analysis of the pathway of Smo transcription for development of new therapeutic strategy inhibiting Hedgehog signaling

2013 - 2016 Molecular Mechanisms of Mitochondrial Fission

2012 - 2015 Development of cancer therapy targeting Hedgehog signaling network

2012 - 2015 ミトコンドリアダイナミクスによる糖・脂質代謝調節機構の解明

2009 - 2014 Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides

2011 - 2013 Mitochondrial dynamics plays important roles in pancreas beta cell and hepatocytes to regulate glucose and lipid metabolism.

2009 - 2012 A study for the generation mechanism and physiological relevance of left-right asymmetry of the brain

2009 - 2011 Functional analysis of Gli1 molecule for developing a new inclusive therapy against many tumor species

2009 - 2010 染色体遺伝子へ影響を与えない全く新しい遺伝子操作マウス創出技術の確立

2008 - 2010 Isolation and regulation of organ specific cancer stem cell

2007 - 2008 Comprehensive analysis of morphogenesis signaling pathways for the development of organ-specific anticancer therapy

2006 - 2008 Regeneration of adrenal gland by soluble factor

2005 - 2008 膵再生に関する研究

2004 - 2008 Basic and clinical research on abnormalities of sexual differentiation associated with synthesis and action of sex steroids

2006 - 2007 Roles of activin and hedgehog signaling in the androgen-independent prostate cancer cells

2006 - 2007 Development the new cancer treatment targeting the regulation system of cancer stem cells

2005 - 2007 Molecular mechanism in the control of central obesity and atherosclerosis by androgen and its target molecule

2005 - 2006 Development of pancreatic cancer therapy and prevention using morphogen as a target signaling pathway

2005 - 2006 Development of the next generation cancer therapy using "Exosomes" by molecular tumor engineering technique

2006 - グルタミン酸と糖代謝

2004 - 2005 The establishment of cell therapy using regenerated-adrenocortical cells tranfected by Ad4BP/SF-1 cDNA

2004 - 2005 A study of inflammatory bowel diseases using Smad2 conditional knockout mice.

2002 - 2004 Elucidation of the mechanism of pancreas development and its application for the regenerative medicine

2001 - 2003 Cloning of androgen receptor AF-1 specific cbactivator gene and development of new drug

2003 - 膵β細胞とミトコンドリアダイナミクス

2000 - 2001 発生工学を用いた性腺・配偶子形成におけるTGF-β/Smadシグナルの機能解析

1999 - 2001 Establishment of new disease concept, nuclear receptor cofactor disease

Engineering the Paucveatic B cells with ES cells

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Papers (34)：

Lixiang Wang, Xin Li, Yuki Hanada, Nao Hasuzawa, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto. Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice. Communications Biology. 2021. 4. 1
Satoko Oda, Kenji Ashida, Makiko Uchiyama, Shohei Sakamoto, Nao Hasuzawa, Ayako Nagayama, Lixiang Wang, Hiromi Nagata, Ryuichi Sakamoto, Junji Kishimoto, et al. An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing’s Syndrome and Autonomous Cortisol Secretion. The Journal of Clinical Endocrinology & Metabolism. 2021. 106. 10. e3865-e3880
Yukina Takeichi, Takashi Miyazawa, Shohei Sakamoto, Yuki Hanada, Lixiang Wang, Kazuhito Gotoh, Keiichiro Uchida, Shunsuke Katsuhara, Ryuichi Sakamoto, Takaya Ishihara, et al. Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. Diabetologia. 2021. 64. 9. 2092-2107
Nao Hasuzawa, Keita Tatsushima, Lixiang Wang, Masaharu Kabashima, Rie Tokubuchi, Ayako Nagayama, Kenji Ashida, Yoshihiro Ogawa, Yoshinori Moriyama, Masatoshi Nomura. Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury. Scientific reports. 2021. 11. 1. 5192-5192
Yuki Hanada, Naotada Ishihara, Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa, Masatoshi Nomura. MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity. Nature communications. 2020. 11. 1. 5711-5711

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MISC (21)：

WuQiang Fan, Toshihiko Yanase, Yoshihiro Nishi, Seiichi Chiba, Taijiro Okabe, Masatoshi Nomura, Hironobu Yoshimatsu, Shigeaki Kato, Ryoichi Takayanagi, Hajime Nawata. Functional Potentiation of Leptin-Signal Transducer and Activator of Transcription 3 Signaling by the Androgen Receptor. ENDOCRINOLOGY. 2008. 149. 12. 6028-6036
CA Ferguson, AS Tucker, K Heikinheimo, M Nomura, P Oh, E Li, PT Sharpe. The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development. DEVELOPMENT. 2001. 128. 22. 4605-4613
柳瀬敏彦, 野村政壽, 大庭功一, 市野功, 高柳涼一, 居石克夫, 諸橋憲一郎, 名和田新. 副腎におけるAd4BP遺伝子の発現に及ぼす下垂体ACTHの影響. ホルモンと臨牀. 2000. 48. 196-198
R Kimura, H Yoshii, M Nomura, N Kotomura, T Mukai, S Ishihara, K Ohba, T Yanase, O Gotoh, H Nawata, et al. Identification of novel first exons in Ad4BP/SF-1 (NR5A1) gene and their tissue- and species-specific usage. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000. 278. 1. 63-71
M Nomura, E Li. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. NATURE. 1998. 393. 6687. 786-790

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Education (4)：

- 1995 Kyushu University
- 1995 Kyushu University Graduate School, Division of Medical Sciences
- 1988 Kyushu University School of Medicine
- 1988 Kyushu University Faculty of Medicine

Professional career (1)：

M.D., Ph.D. (Kyushu University)

Work history (6)：

1997 - 1999 ハーバード医科大研究員
1997 - 1999 Post doctral fellow at Hanuard Medical School
1996 - 1999 日本学術振興会特別研究員
1999 - - 九州大学
1999 - - Assistant Prof, Department of Medicine, Kyushu

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Committee career (1)：

日本内科学会日本糖尿病学会

Awards (4)：

2012/04 - 日本医師会日本医師会医学研究奨励賞
2001 - 小野寺研究奨励賞
2001 - 日本内分泌学会研究奨励賞
1995 - 井上研究奨励賞

Association Membership(s) (6)：

日本ステロイドホルモン学会 , 日本内分泌学会 , 日本再生医療学会 , 米国内分泌学会 , 日本糖尿病学会 , 日本内科学会

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