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J-GLOBAL ID：200901068753795130 Update date: Jan. 07, 2025

Yaoi Takeshi

ヤオイタケシ | Yaoi Takeshi

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Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www2.kpu-m.ac.jp/~neurpath/top.html

Research field (4)： Molecular biology , Environmental effects of chemicals , Environmental effects of radiation , Neuroscience - general

Research keywords (13)：空間トランスクリプトミクス , Alternative Splicing , bioinfomatics , Spread Through Air Space , Lung cancer , Bisphenol A , 単一細胞解析 , 環境化学物質 , ディストロフィン , 内分泌攪乱物質 , エピジェネティクス , 脳形成 , Molecular Neurobiology

Research theme for competitive and other funds (28)：

2024 - 2027 The elucidation of the pathogenesis of ovarian aging by Premature Ovarian Insufficiency using ASPM knockout mouse and Spatial Transcriptomics
2022 - 2025 Spread through air spaces in pulmonary metastases from colorectal cancer analysed with cancer tissue-originated spheroid
2020 - 2025 Molecular Mechanism of Spread Through Air Space in Lung Cancer
2023 - 2024 早期肺癌患者に対する適切な根治的術式選択のためのSTAS術前診断法の開発
2021 - 2024 Elucidation of the cancer microenvironment for the development of STAS in lung adenocarcinoma as a fundamental of the development of markers for pathological search and preoperative diagnosis

2013 - 2016 Dose the fetal exposure to environmental chemicals have a impact on the alternative splicing profiles in post weaning brain via its epigenetic changes ?

2010 - 2012 Analyses on the pathogenesis of L1-associated hydrocephalus by knocking down L1 and TAG-1

2009 - 2011 Changes of Transcriptome and DNA methylation in P19 neurons exposed to Bisphenol A

2008 - 2010 Studies on the effects of prenatal exposure to bisphenol A in mouse brain, with special reference to neuronal migration and epigenetic alteratio ns

2008 - 2009 環境中ナノ粒子の脳老化、神経変性疾患への寄与に関する探索的研究

2007 - ディストロフィン遺伝子(DMD)産物の機能解析

2005 - 2006 Study of the tumor suppression mechanism of TARSH, senescence-related gene and its application for diagnosis in lung tumor.

1996 - 2006 末梢神経再生修復機構に関する研究

2003 - 2004 Effects of endocrine disruptors on developing brain, with special reference to gene expression.

2003 - 2004 Expression of the gene associated with nerve regeneration in the nucleus ambiguous after the recurrent nerve injury.

2003 - 2004 皮膚繊維芽細胞への張力負荷の影響における分子的基盤の研究

2002 - 2003 Identification of novel subtype of LPA receptors expressed in terminal Schwann cell

2001 - 2002 Functional analysis of neuronal migration-associated genes in murine brains by in utero gene transfer techniques with GFP reporter genes.

2001 - 2002 シナプス形成・維持に寄与する神経筋接合部シュワン細胞に特異的な遺伝子の同定

2001 - 2002 マウス胎性期大脳皮質形成に関与する,リガンド未知の新規核内受容体の同定

2000 - 2001 SDNFと名づけたシュワン細胞由来神経突起伸長因子の同定・精製と神経修復への応用

1999 - 2000 Search for genes involved in neuronal migration in cerebral cortex of X-irradiated embryonic mice

1999 - 2000 単一細胞RLCS法を用いた神経細胞虚血耐性関連遺伝子の探索

2000 - マウス胎仔脳における内分泌攪乱物質ビスフェノールA曝露影響に関する研究

1998 - 大脳皮質形成の分子機構に関する研究

Effects of maternal exposure of endocrine disruptor on murine brain development

Identification of Nerve regeneration-related Genes

Study on Molecular mechanism of Neuronal Migration

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Papers (32)：

Takahiro Fujimoto, Miyuki Mori, Madoka Tonosaki, Takeshi Yaoi, Kenta Nakano, Tadashi Okamura, Kyoko Itoh. Characterization of Dystrophin Dp71 Expression and Interaction Partners in Embryonic Brain Development: Implications for Duchenne/Becker Muscular Dystrophy. Molecular neurobiology. 2025
Akihiro Yoshimura, Mano Horinaka, Takeshi Yaoi, Hisako Ono, Kyoko Itoh, Tadaaki Yamada, Koichi Takayama, Toshiyuki Sakai. Epithelial-mesenchymal transition status is a remarkable biomarker for the combination treatment with avutometinib and defactinib in KRAS-mutated non-small cell lung cancer. British journal of cancer. 2024
Madoka Tonosaki, Akira Fujimori, Takeshi Yaoi, Kyoko Itoh. Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis. PLOS ONE. 2023. 18. 11. e0294893-e0294893
Hisashi Takahashi, Takahiro Fujimoto, Takeshi Yaoi, Shinji Fushiki, Kyoko Itoh. Leukemia inhibitory factor shortens primary cilia by upregulating C-C motif chemokine 2 in human neural stem/progenitor cells. Genes to cells : devoted to molecular & cellular mechanisms. 2023
Ryota Nakamura, Hiroyuki Fujii, Tadaaki Yamada, Yohei Matsui, Takeshi Yaoi, Mizuki Honda, Noriyuki Tanaka, Aya Miyagawa-Hayashino, Akihiro Yoshimura, Kenji Morimoto, et al. Analysis of Tumor Heterogeneity Through AXL Activation in Primary Resistance to EGFR Tyrosine Kinase Inhibitors. JTO clinical and research reports. 2023. 4. 6. 100525-100525

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MISC (61)：

内堀篤樹, 内堀篤樹, 矢追毅, 丹藤創, 井上匡美, 伊東恭子. Molecular pathology of spread through air spaces (STAS), a novel pattern of tumor metastasis in non-small cell lung cancer. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
Shogen Boku, Motoki Watanabe, Mamiko Sukeno, Takeshi Yaoi, Kiichi Hirota, Mahiro Iizuka, Kyoko Itoh, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, et al. MO18-7 Combinatorial treatments of aspirin with glutaminolysis-targeting agents against PIK3CA-mutated colorectal cancer cells. Annals of Oncology. 2021. 32. S309-S309
下村雅律, 矢追毅, 加藤大志朗, 島田順一, 伏木信次. 肺癌細胞株におけるパクリタキセルに対する薬剤耐性機序に関する因子の検討. 日本呼吸器外科学会総会(Web). 2013. 30th. 3. P03-01 (WEB ONLY)-01
下村雅律, 矢追毅, 加藤大志朗, 寺内邦彦, 島田順一, 伏木信次. 肺癌細胞株においてパクリタキセルの細胞内局在の相違は薬剤耐性に関与する. 日本呼吸器外科学会総会(Web). 2012. 29th. 3. O19-02 (WEB ONLY)-02
下村雅律, 矢追毅, 伊東恭子, 加藤大志朗, 寺内邦彦, 島田順一, 伏木信次. PS-111-5 肺癌細胞株におけるパクリタキセルへの薬剤耐性はATP-binding cassette, sub-family B, member 1 (ABCB1)遺伝子の発現のみならず,細胞内コンパートメントへの薬剤集積が関与する(PS-111 肺基礎-3,ポスターセッション,第112回日本外科学会定期学術集会). 日本外科学会雑誌. 2012. 113. 2. 714-714

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Patents (4)：

多遺伝子同時検出法
新規な脳特異的タンパク質およびそれをコードする遺伝子
遺伝子の変異同定法
METHOD FOR THE SIMULTANEOUS DETECTION OF POLYGENES

Books (2)：

Yaoi, T., et.al., RLCS, restriction landmark cDNA scanning, in Restriction Landmark Genomic Scanning (RLGS) (Hayashizaki Y and Watanabe S ed.)
Springer Verlag 1997
RLCS, Restriction Landmark CDNA Scanning In Restriction Landmark Genomic Scanning(RLGS)(Y. Hayashizaki, S. Watanabe Eds. )
Springer 1997

Lectures and oral presentations (3)：

非小細胞肺癌における新規腫瘍転移様式STASの分子病理学的解析
(第46回日本分子生物学会年会 2023)
非小細胞肺癌における新規腫瘍転移様式の分子病理学的解析
(第7回北陸エピジェネティクス研究会 2023)
STAS(Spread Through Air Spaces)を有する肺腺癌の次世代シークエンスによる病態解明と診断マーカーの探求
(第123回日本外科学会定期学術集会 2023)

Education (3)：

- 1989 Kyushu University
- 1989 Kyushu University Graduate School, Division of Pharmaceutical Sciences
- 1987 Kyoto Pharmaceutical University

Professional career (1)：

Master of Pharmaceutical Science

Association Membership(s) (4)：

日本エピジェネティクス研究会 , 日本神経科学会 , 日本分子生物学会 , 北陸エピジェネティクス研究会

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