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J-GLOBAL ID：200901069433129952 Update date: Mar. 11, 2025

Hisakazu Ohtani

オオタニヒサカズ | Hisakazu Ohtani

Affiliation and department：
Job title： Professor
Other affiliations (2)：

Research field (2)： Pharmacology , Clinical pharmacy

Research keywords (5)： drug interactions , interindividual variation of pharmacokinetics , personalized medication , generative AI , pharmacometrics

Research theme for competitive and other funds (16)：

2018 - 2021 Analysis of the inter-individual variations of food-drug interactions via CYP2Cs and OATPs
2018 - 2021 CYP2Cs及びOATPsを介した薬物ー飲食物間相互作用とその個人差の定量的解明
2015 - 2018 Quantitative analysis of the factors that confer inter-individual variation of the extent of beverage-drug interactions
2015 - 2018 薬物-飲食物間相互作用の強度に個人差をもたらす遺伝的要因の解明
2012 - 2015 Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450

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Papers (218)：

Keisuke Kiyomiya, Tohru Aomori, Hisakazu Ohtani. Medication counseling for OTC drugs using customized ChatGPT-4: Comparison with ChatGPT-3.5 and ChatGPT-4o. DIGITAL HEALTH. 2025
Kana Koinuma, Kenji Noto, Tokio Morita, Yoshinori Uekusa, Haruhisa Kikuchi, Miyuki Shimoji, Hiroyuki Seki, Hiroshi Yamazaki, F. Peter Guengerich, Katsunori Nakamura, et al. Kinetics of the Inhibition of CYP3A4 and CYP2C19 Activity by Jabara Juice and Identification of the Responsible Inhibitory Components. Journal of Pharmaceutical Sciences. 2024
Hiroki Kataoka, Takeshi Akiyoshi, Yasuo Uchida, Ayuko Imaoka, Tetsuya Terasaki, Hisakazu Ohtani. The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1. Journal of Pharmaceutical Sciences. 2024. 113. 5. 1376-1384
Kiyomiya K, Aomori T, Ohtani H. Comprehensive analysis of responses from ChatGPT to consumer inquiries regarding over-the-counter medications. Die Pharmazie. 2024. 79. 1. 24-28
Kodai Yajima, Takeshi Akiyoshi, Kazuho Sakamoto, Yoshiaki Suzuki, Takayuki Oka, Ayuko Imaoka, Hisao Yamamura, Junko Kurokawa, Hisakazu Ohtani. Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach. Journal of Pharmacological Sciences. 2023. 153. 3. 153-160

MISC (367)：

神成はるか, 西松直美, 小谷宙, 櫻井洋臣, 村松博, 青森達, 大谷壽一. PBPMに基づく薬剤師面談は外来患者の薬物治療の適正化とアドヒアランス向上をもたらす. 日本エイズ学会誌. 2023. 25. 4. 431-431
大谷壽一. 骨髄腫の薬物治療の留意点薬物動態と薬物相互作用の視点から(Pharmacokinetic aspects of drugs used for the treatment of myeloma). International Journal of Myeloma. 2023. 13. 3. 95-95
大谷壽一. 薬物相互作用の科学的評価とpersonalized medicationへの応用. TDM研究. 2022. 39. 2. 38-38
鈴木玲奈, 今岡鮎子, 秋好健志, 大谷壽一. マグネシウムの消化管吸収に対するシプロフロキサシンの影響. 日本薬学会年会要旨集. 2022. 142年会. 27PO5-am2
土谷聡耀, 秋好健志, 今岡鮎子, 大谷壽一. 消化管吸収過程におけるP糖蛋白質を介した薬物相互作用のin vitro ATPase活性からの予測. 日本薬学会年会要旨集. 2022. 142年会. 27PO5-am2

Books (22)：

Lectures and oral presentations (92)：

Generative AI in Pharmacy Practice: Revolution or Troublesome Technology?
(2024)
Drug-beverage interaction
(29th Dubai International Pharmaceutical & Technologies Conference & Exhibition - DUPHAT 2023)
Pharmacy education in Japan - Clinical rotation and preceptorship -
(Seminar National. Asosiasi Pendidikan Tinggi Farmasi Indonesia (APTFI) II 2017)
医療連携で薬剤師に求められる臨床薬物動態学の基本
(日本薬学会関東支部薬剤師向け研修講演会 2017)
受理される論文・されない論文
(第1回医療薬学教育セミナー 2017)

Education (2)：

Professional career (1)：

Work history (9)：

2021/10 - 現在 Keio University Hospital Department of Pharmacy Director of Pharmacy
2021/09/01 - 現在 Keio University School of Medicine Professor
2009/04 - 2021/08/31 Keio University Faculty of Pharmacy Department of Clinical Pharmacokinetics Professor
2008/04 - 2009/03 Adjunct Associate Professor, Graduate School of Interdisciplinary Information Studies The University of Tokyo
2005/04 - 2009/03 Associate Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo

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Committee career (30)：

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Awards (6)：

2023/11 - 日本医療薬学会日本医療薬学会賞薬物相互作用の個人差に関する医療薬学的研究
2014/03 - 日本薬学会第134年会年会優秀発表賞 In vitro データをもとにした、CYP2D6 variants における paroxetine の非線型体内動態の予測.
2013/08 - 医薬品情報学会 (第16回日本医薬品情報学会総会・学術大会) 最優秀ポスター賞免疫抑制剤、βblocker、ステロイドの低用量域における全身性副作用の用量依存性評価.
2013/03 - 日本薬学会第133年会優秀発表賞学生主体で構築した新たな服薬指導事前実習の評価.
2010/07 - 医療薬学フォーラム2010/第18回クリニカルファーマシーシンポジウム優秀ポスター賞 CYP3A4 変異型分子種の代謝活性に対する阻害剤の阻害強度の比較.

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Association Membership(s) (4)：

日本医療薬学会 , The Pharmaceutical Society of Japan , 日本薬理学会 , Japanese Society of Drug Informatics (JASDI)

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