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J-GLOBAL ID：200901069443444201 Update date: Feb. 01, 2024

Nakagawa Toshiyuki

ナカガワトシユキ | Nakagawa Toshiyuki

Affiliation and department：
Other affiliations (1)：

医学系研究科教授

Homepage URL (1)： http://www1.gifu-u.ac.jp/~neurobio/

Research field (4)： Medical biochemistry , Neuroscience - general , Home economics, lifestyle science , Pathobiochemistry

Research keywords (36)： apoptosis , ER stress , endoplasmic reticulum , neurodegeneration , 痴呆 , 神経内科 , 神経生物 , カスパーゼ , 神経変性 , Apaf-1 , スクリーニング , 蛋白質品質管理 , GADD34 , 基質 , 神経分化 , 細胞内小器官 , ERAD , eIF2α , ロイシン , 神経変性疾患 , オートファジー , Bcl-xL , 再生 , レスベラトロール , アルツハイマー病 , アミノ酸センサー , 転写因子 , ミトコンドリア , カスペース , 加齢 , アポトーシス , アミロイドーβ , ATF4 , GCN2 , プレセニリン , ガンマ-セクレターゼ

Research theme for competitive and other funds (42)：

2020 - 2023 Therapeutic targeting the endoplasmic reticulum stressto delay onset of Alzheimer's disease
2017 - 2020 Analysis of functional food to prevent wandering caused by impairment of memory recalll
2014 - 2017 Analysis of prevention of Alzheimer's disease based on underlying pathology
2014 - 2016 アルツハイマー病病態に基づく発症予防法の解明
2014 - 2016 アルツハイマー病病態に基づく発症予防法の解明

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Papers (52)：

Yuichi Hayashi, Fuminori Hyodo, Tana, Kiyomi Nakagawa, Takuma Ishihara, Masayuki Matsuo, Takayoshi Shimohata, Jun Nishihira, Masuko Kobori, Toshiyuki Nakagawa. Continuous intake of quercetin-rich onion powder may improve emotion but not regional cerebral blood flow in subjects with cognitive impairment. Heliyon. 2023. 9. 8. e18401
Miki Hayakawa-Ogura, Tana, Toshiyuki Nakagawa, Masanori Itoh. GADD34 suppresses eIF2α phosphorylation and improves cognitive function in Alzheimer's disease-model mice. Biochemical and Biophysical Research Communications. 2023
Kiyomi Nakagawa, Saiful Islam, Masashi Ueda, Toshiyuki Nakagawa. Endoplasmic reticulum stress contributes to the decline in doublecortin expression in the immature neurons of mice with long-term obesity. Scientific reports. 2022. 12. 1. 1022-1022
Tana, Toshiyuki Nakagawa. Luteolin ameliorates depression-like behaviors by suppressing ER stress in a mouse model of Alzheimer's disease. Biochemical and biophysical research communications. 2022. 588. 168-174
Jun Nishihira, Mie Nishimura, Masanori Kurimoto, Hiroyo Kagami-Katsuyama, Hiroki Hattori, Toshiyuki Nakagawa, Takato Muro, Masuko Kobori. The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial. Journal of Clinical Biochemistry and Nutrition. 2021. 69. 2. 203-215

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MISC (9)：

早川実希, 伊藤正徳, 太田和徳, 李詩沫, 上田昌史, 王びょう星, 西田江美香, 中川敏幸. 肥満・糖尿病によるアルツハイマー病モデルマウスの病態解明. 機能性食品と薬理栄養. 2014. 8. 5
太田和徳, 中川敏幸. 認知症-特集医農連携と機能性食品. Functional food : フードサイエンスと臨床をつなぐ専門誌. 2011. 5. 1. 47-51
太田和徳, 中川敏幸. ケルセチンとアルツハイマー病 (特集食品と疾病 : ケルセチン). Functional food : 機能性食品の基礎から臨床へ. 2011. 5. 2. 135-138
鈴木欣宏, 太田和徳, 伊藤正徳, 上田昌史, 李詩沫, 樋田陽子, 酒向ゆかり, 光田輝彦, 矢野佳芳, 犬塚貴, et al. γ-セクレターゼの活性を制御する新規プレセニリン2アイソフォームの解析. 臨床神経学. 2009. 49. 12. 1078-1078
鈴木欣宏, 酒向ゆかり, 光田輝彦, 矢野佳芳, 川, 伊藤正徳, 上田昌史, 太田和徳, 李詩沫, 犬塚貴, et al. γ-セクレターゼ活性を制御する新規プレセニリン2アイソフォームの解析. 臨床神経学. 2007. 47. 12. 995-995

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Lectures and oral presentations (23)：

Synaptic localization ofcayman ataxia-related protein, caytaxin
(2007)
Leucine and lysine as nutritional signal regulate amyloid-b production via INTEGRATED STRESS RESPONSE
(2007)
Aminoacid imbalance enhances presenilin-1 expression,regulating amyloid-b production and notch signaling
(2006)
Translational control of γ-secretase activity by GCN2/eIF2α/ATF4 pathway
(2006)
The roles of Cayman ataxia related gene product, Caytaxin, in neural development
(2006)

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Education (2)：

1989 - 1993 Osaka University
- 1984 Kumamoto University School of Medicine School of Medicine

Professional career (1)：

博士(医学) (大阪大学)

Work history (5)：

2001 - 現在 Gifu University
1995 - 2001 Harvard University
1993 - 1995 Department of Cell Biology, Cancer Institute
1988 - 1989 Arao city hospital
1984 - 1988 Department of 1st internal medicine, Kumamoto university, School of Medicine

Association Membership(s) (5)：

米国神経科学学会 , 日本内科学会 , 日本分子生物学会 , 日本神経化学学会 , 日本神経学会

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